(2-Butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone

Product Name: (2-Butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone
CAS No.: 141627-42-1
Chemical Name: (2-Butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone
Synonyms: Dronedaron Impurity E;Dronedarone Impurity E;Dronedarone Impurity 22;Dronedarone Impurity SM1-F (Impurity 5);2-butyl-3-(4-methoxybenzoyl)-5-nitrobenzofuran;2-n-Butyl-3-(4-methoxybenzoyl)-5-nitrobenzofuran;(2-Butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone;(2-butyl-5-nitro-3-benzofuranyl)(4-methoxyphenyl)Methanone;2-butyl-3-[(4-Methoxyphenyl)carbonyl]-5-nitro-1-benzofuran;Methanone, (2-butyl-5-nitro-3-benzofuranyl)(4-methoxyphenyl)-
CBNumber: CB62500623
Molecular Formula: C20H19NO5
Formula Weight: 353.37
MOL File: 141627-42-1.mol

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(2-Butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone Property

Boiling point:: 537.7±50.0 °C(Predicted)
Density: 1.234±0.06 g/cm3(Predicted)
storage temp.: Storage temp. 2-8°C
Appearance: Yellow to brown Solid
InChI: InChI=1S/C20H19NO5/c1-3-4-5-18-19(20(22)13-6-9-15(25-2)10-7-13)16-12-14(21(23)24)8-11-17(16)26-18/h6-12H,3-5H2,1-2H3
InChIKey: WYALRXZJYXWYGR-UHFFFAOYSA-N
SMILES: C(C1C2=CC([N+]([O-])=O)=CC=C2OC=1CCCC)(C1=CC=C(OC)C=C1)=O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B693905
Product name: (2-Butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone
Packaging: 25g
Price: $330
Updated: 2021/12/16

ChemScene

Product number: CS-M0181
Product name: (2-Butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone
Purity: 99.53%
Packaging: 25g
Price: $400
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB151853
Product name: (2-Butyl-5-nitro-benzofuran-3-yl)-(4-methoxy-phenyl)-methanone
Packaging: 25mg
Price: $405
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0388105
Product name: (2-BUTYL-5-NITROBENZOFURAN-3-YL)(4-METHOXYPHENYL)METHANONE
Purity: 95.00%
Packaging: 5MG
Price: $505.59
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB151853
Product name: (2-Butyl-5-nitro-benzofuran-3-yl)-(4-methoxy-phenyl)-methanone
Packaging: 50mg
Price: $704
Updated: 2021/12/16

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(2-Butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone Chemical Properties,Usage,Production

Uses

(2-Butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone is a reagent in the preparation of heterocyclic benzofuran carboxamides via amidation of heterocyclic acyl chlorides with benzofuranamine. This is also a derivative of Dronedarone (D679445),which is a drug used for the treatment of atrial fibrillation and atrial flutter in patients who have suffered cardiac arrhythmias.

Synthesis

100-07-2

133238-87-6

141627-42-1

Method-2: A solution of 45 g (0.2 mol) of 2-butyl-5-nitrobenzofuran and 44 g of p-methoxybenzoyl chloride in 300 ml of chlorobenzene was added to a round bottomed flask at 25 °C. To the reaction mixture was slowly added a solution of 40 g of aluminum chloride in 300 ml of chlorobenzene. The reaction system was heated to reflux for 2 hours, subsequently cooled to room temperature and diluted with 40 ml of water. The organic phase was separated and washed sequentially with water and 5% sodium bicarbonate solution. The organic phase was concentrated to dryness under reduced pressure and the resulting product was rapidly crystallized. By recrystallization from 270 ml of isopropanol, 2-butyl-3-(4-methoxybenzoyl)-5-nitrobenzofuran was obtained with a melting point of 94-96°C and HPLC purity >96%.

References

[1] Patent: WO2012/32545, 2012, A1. Location in patent: Page/Page column 32
[2] Journal of the Chinese Chemical Society, 2011, vol. 58, # 7, p. 841 - 845
[3] Patent: US5223510, 1993, A
[4] Journal of Chemical Sciences, 2012, vol. 124, # 5, p. 1077 - 1085
[5] Organic Process Research and Development, 2014, vol. 18, # 1, p. 157 - 162

(2-Butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone Preparation Products And Raw materials

Raw materials

Preparation Products

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(2-Butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone Suppliers

China 114 India 11 United Kingdom 1 United States 7 Global 133

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View Lastest Price from (2-Butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone manufacturers

Hebei Zhanyao Biotechnology Co. Ltd

Product: Methanone,(2-butyl-5-nitro-3-benzofuranyl)(4-methoxyphenyl)- CAS 141627-42-1 141627-42-1
Price: US $10.00/KG
Min. Order: 1g
Purity: 99%
Supply Ability: 20 tons
Release date: 2021-09-03

Career Henan Chemical Co

Product: (2-Butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone 141627-42-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1lg; 2kg; 5kg; 10kg; 100kg
Release date: 2019-08-31

141627-42-1, (2-Butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanoneRelated Search:

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(2-Butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone

2-butyl-3-(4-methoxybenzoyl)-5-nitrobenzofuran

Methanone, (2-butyl-5-nitro-3-benzofuranyl)(4-methoxyphenyl)-

2-butyl-3-[(4-Methoxyphenyl)carbonyl]-5-nitro-1-benzofuran

(2-butyl-5-nitro-3-benzofuranyl)(4-methoxyphenyl)Methanone

Dronedarone Impurity E

(2-butyl-5-nitro-1-benzofuran-3-yl)-(4-methoxyphenyl)methanone

Methanone,(2-butyl-5-nitro-3-benzofuranyl)(4-methoxyphenyl)- CAS 141627-42-1

Dronedaron Impurity E

Dronedarone Impurity 22

(2-Butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone (BNB-V)

2-n-Butyl-3-(4-methoxybenzoyl)-5-nitrobenzofuran

Dronedarone Impurity SM1-F (Impurity 5)

141627-42-1

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