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(2-Butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone

Product Name
(2-Butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone
CAS No.
141627-42-1
Chemical Name
(2-Butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone
Synonyms
Dronedaron Impurity E;Dronedarone Impurity E;Dronedarone Impurity 22;Dronedarone Impurity SM1-F (Impurity 5);2-butyl-3-(4-methoxybenzoyl)-5-nitrobenzofuran;2-n-Butyl-3-(4-methoxybenzoyl)-5-nitrobenzofuran;(2-Butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone;(2-butyl-5-nitro-3-benzofuranyl)(4-methoxyphenyl)Methanone;2-butyl-3-[(4-Methoxyphenyl)carbonyl]-5-nitro-1-benzofuran;Methanone, (2-butyl-5-nitro-3-benzofuranyl)(4-methoxyphenyl)-
CBNumber
CB62500623
Molecular Formula
C20H19NO5
Formula Weight
353.37
MOL File
141627-42-1.mol
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(2-Butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone Property

Boiling point:
537.7±50.0 °C(Predicted)
Density 
1.234±0.06 g/cm3(Predicted)
storage temp. 
Storage temp. 2-8°C
Appearance
Yellow to brown Solid
InChI
InChI=1S/C20H19NO5/c1-3-4-5-18-19(20(22)13-6-9-15(25-2)10-7-13)16-12-14(21(23)24)8-11-17(16)26-18/h6-12H,3-5H2,1-2H3
InChIKey
WYALRXZJYXWYGR-UHFFFAOYSA-N
SMILES
C(C1C2=CC([N+]([O-])=O)=CC=C2OC=1CCCC)(C1=CC=C(OC)C=C1)=O
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B693905
Product name
(2-Butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone
Packaging
25g
Price
$330
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB151853
Product name
(2-Butyl-5-nitro-benzofuran-3-yl)-(4-methoxy-phenyl)-methanone
Packaging
2mg
Price
$59
Updated
2021/12/16
ChemScene
Product number
CS-M0181
Product name
(2-Butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone
Purity
99.53%
Packaging
5g
Price
$105
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB151853
Product name
(2-Butyl-5-nitro-benzofuran-3-yl)-(4-methoxy-phenyl)-methanone
Packaging
5mg
Price
$117
Updated
2021/12/16
ChemScene
Product number
CS-M0181
Product name
(2-Butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone
Purity
99.53%
Packaging
10g
Price
$180
Updated
2021/12/16
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(2-Butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone Chemical Properties,Usage,Production

Uses

(2-Butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone is a reagent in the preparation of heterocyclic benzofuran carboxamides via amidation of heterocyclic acyl chlorides with benzofuranamine. This is also a derivative of Dronedarone (D679445),which is a drug used for the treatment of atrial fibrillation and atrial flutter in patients who have suffered cardiac arrhythmias.

Synthesis

100-07-2

133238-87-6

141627-42-1

Method-2: A solution of 45 g (0.2 mol) of 2-butyl-5-nitrobenzofuran and 44 g of p-methoxybenzoyl chloride in 300 ml of chlorobenzene was added to a round bottomed flask at 25 °C. To the reaction mixture was slowly added a solution of 40 g of aluminum chloride in 300 ml of chlorobenzene. The reaction system was heated to reflux for 2 hours, subsequently cooled to room temperature and diluted with 40 ml of water. The organic phase was separated and washed sequentially with water and 5% sodium bicarbonate solution. The organic phase was concentrated to dryness under reduced pressure and the resulting product was rapidly crystallized. By recrystallization from 270 ml of isopropanol, 2-butyl-3-(4-methoxybenzoyl)-5-nitrobenzofuran was obtained with a melting point of 94-96°C and HPLC purity >96%.

References

[1] Patent: WO2012/32545, 2012, A1. Location in patent: Page/Page column 32
[2] Journal of the Chinese Chemical Society, 2011, vol. 58, # 7, p. 841 - 845
[3] Patent: US5223510, 1993, A
[4] Journal of Chemical Sciences, 2012, vol. 124, # 5, p. 1077 - 1085
[5] Organic Process Research and Development, 2014, vol. 18, # 1, p. 157 - 162

(2-Butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone Preparation Products And Raw materials

Raw materials

Preparation Products

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(2-Butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone Suppliers

China 114 India 11 United Kingdom 1 United States 7 Global 133
Carbosynth
Tel
--
Fax
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Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
Advantage
58
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View Lastest Price from (2-Butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone manufacturers

Hebei Zhanyao Biotechnology Co. Ltd
Product
Methanone,(2-butyl-5-nitro-3-benzofuranyl)(4-methoxyphenyl)- CAS 141627-42-1 141627-42-1
Price
US $10.00/KG
Min. Order
1g
Purity
99%
Supply Ability
20 tons
Release date
2021-09-03
Career Henan Chemical Co
Product
(2-Butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone 141627-42-1
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1lg; 2kg; 5kg; 10kg; 100kg
Release date
2019-08-31

141627-42-1, (2-Butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanoneRelated Search:

4-(alpha-Methylbenzyl)resorcinol

  • (2-Butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone
  • 2-butyl-3-(4-methoxybenzoyl)-5-nitrobenzofuran
  • Methanone, (2-butyl-5-nitro-3-benzofuranyl)(4-methoxyphenyl)-
  • 2-butyl-3-[(4-Methoxyphenyl)carbonyl]-5-nitro-1-benzofuran
  • (2-butyl-5-nitro-3-benzofuranyl)(4-methoxyphenyl)Methanone
  • Dronedarone Impurity E
  • (2-butyl-5-nitro-1-benzofuran-3-yl)-(4-methoxyphenyl)methanone
  • Methanone,(2-butyl-5-nitro-3-benzofuranyl)(4-methoxyphenyl)- CAS 141627-42-1
  • Dronedaron Impurity E
  • Dronedarone Impurity 22
  • (2-Butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone (BNB-V)
  • 2-n-Butyl-3-(4-methoxybenzoyl)-5-nitrobenzofuran
  • Dronedarone Impurity SM1-F (Impurity 5)
  • 141627-42-1
  • API