ChemicalBook > CAS DataBase List > (2S,4R)-1-Boc-2-cyano-4-hydroxypyrrolidine

(2S,4R)-1-Boc-2-cyano-4-hydroxypyrrolidine

Product Name: (2S,4R)-1-Boc-2-cyano-4-hydroxypyrrolidine
CAS No.: 483366-12-7
Chemical Name: (2S,4R)-1-Boc-2-cyano-4-hydroxypyrrolidine
Synonyms: (2S,4R)-1-Boc-2-cyano-4-hydroxypyrrolidine;(2S,4R)-N-Boc-trans-2-cyano-4-hydroxypyrrolidine;-tert-Butyl 2-cyano-4-hydroxypyrrolidine-1-carboxylate;(2S,4R)-tert-Butyl 2-cyano-4-hydroxypyrrolidine-1-carboxylate;1-Pyrrolidinecarboxylic acid, 2-cyano-4-hydroxy-, 1,1-dimethylethyl ester, (2S,4R)-
CBNumber: CB62500719
Molecular Formula: C10H16N2O3
Formula Weight: 212.25
MOL File: 483366-12-7.mol

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(2S,4R)-1-Boc-2-cyano-4-hydroxypyrrolidine Property

Boiling point:: 361.4±42.0 °C(Predicted)
Density: 1.19±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 13.90±0.40(Predicted)
form: solid
color: White
InChI: InChI=1S/C10H16N2O3/c1-10(2,3)15-9(14)12-6-8(13)4-7(12)5-11/h7-8,13H,4,6H2,1-3H3/t7-,8+/m0/s1
InChIKey: UNVNZVOSYRUJTH-JGVFFNPUSA-N
SMILES: N1(C(OC(C)(C)C)=O)C[C@H](O)C[C@H]1C#N

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: B201370
Product name: (2S,4R)-1-Boc-2-cyano-4-hydroxypyrrolidine
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Apolloscientific

Product number: OR952355
Product name: (2S,4R)-1-Boc-2-Cyano-4-hydroxypyrrolidine
Purity: 98%
Packaging: 1g
Price: $93
Updated: 2021/12/16

Apolloscientific

Product number: OR952355
Product name: (2S,4R)-1-Boc-2-Cyano-4-hydroxypyrrolidine
Purity: 98%
Packaging: 5g
Price: $278
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CCH0031619
Product name: (2S,4R)-1-BOC-2-CYANO-4-HYDROXYPYRROLIDINE
Purity: 95.00%
Packaging: 1G
Price: $289.8
Updated: 2021/12/16

Apolloscientific

Product number: OR952355
Product name: (2S,4R)-1-Boc-2-Cyano-4-hydroxypyrrolidine
Purity: 98%
Packaging: 25g
Price: $755
Updated: 2021/12/16

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(2S,4R)-1-Boc-2-cyano-4-hydroxypyrrolidine Chemical Properties,Usage,Production

Synthesis

109384-24-9

483366-12-7

General procedure for the synthesis of (2S,4R)-1-Boc-2-carbamoyl-4-hydroxypyrrolidine from (2S,4R)-1-Boc-2-cyano-4-hydroxypyrrolidine: 7.82 g (34 mmol) of (2S,4R)-1-Boc-2-carbamoyl-4-hydroxypyrrolidine was dissolved in 80 mL of pyridine, followed by a slow addition of 12 mL (84 mmol) trifluoroacetic anhydride. The reaction mixture was cooled to -20 °C and the reaction was stirred at this temperature. Upon completion of the reaction, the mixture was warmed to room temperature and stirring was continued for 24 hours. The excess trifluoroacetic anhydride was quenched by adding an appropriate amount of water. To the reaction mixture was added 200 mL of ethyl acetate, and the organic layer was washed sequentially with 10% aqueous hydrochloric acid (adjusting the pH to 3-5), 50 mL of 2 N sodium hydroxide solution, and 50 mL of saturated saline. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give an oily product. Yield: 5.35 g (74% yield).

References

[1] Patent: WO2003/106456, 2003, A2. Location in patent: Page 28
[2] Patent: EP2246347, 2010, A1. Location in patent: Page/Page column 39

(2S,4R)-1-Boc-2-cyano-4-hydroxypyrrolidine Preparation Products And Raw materials

Raw materials

Preparation Products

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483366-12-7, (2S,4R)-1-Boc-2-cyano-4-hydroxypyrrolidineRelated Search:

(2S,4R)-tert-Butyl 2-cyano-4-hydroxypyrrolidine-1-carboxylate

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(2S,4R)-1-Boc-2-cyano-4-hydroxypyrrolidine

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