1H-pyrazolo[3,4-b]pyridine-3-carbonitrile

Product Name: 1H-pyrazolo[3,4-b]pyridine-3-carbonitrile
CAS No.: 956010-88-1
Chemical Name: 1H-pyrazolo[3,4-b]pyridine-3-carbonitrile
Synonyms: 1H-pyrazolo[3;Piraxostat Impurity 30;4-b]pyridine-3-carbonitrile;2H-pyrazolo[3,4-b]pyridine-3-carbonitrile;1H-pyrazolo[3,4-b]pyridine-3-carbonitrile;1H-pyrazole and [3, 4-b] pyridine-3-methyl nitrile
CBNumber: CB62500870
Molecular Formula: C7H4N4
Formula Weight: 144.13
MOL File: 956010-88-1.mol

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1H-pyrazolo[3,4-b]pyridine-3-carbonitrile Property

Boiling point:: 397.1±22.0 °C(Predicted)
Density: 1.44±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 6.78±0.40(Predicted)
Appearance: White to off-white Solid

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Safety

RIDADR: UN2811
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

AK Scientific

Product number: 6483AC
Product name: 1H-Pyrazolo[3,4-b]pyridine-3-carbonitrile
Packaging: 1g
Price: $184
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H37-1-33
Product name: 1H-Pyrazolo[3,4-b]pyridine-3-carbonitrile
Packaging: 1g
Price: $375
Updated: 2021/12/16

Apolloscientific

Product number: OR931536
Product name: 1H-Pyrazolo[3,4-b]pyridine-3-carbonitrile
Purity: 95%
Packaging: 1g
Price: $555
Updated: 2021/12/16

Matrix Scientific

Product number: 113321
Product name: 1H-Pyrazolo[3,4-b]pyridine-3-carbonitrile
Packaging: 1g
Price: $851
Updated: 2021/12/16

Alichem

Product number: 956010881
Product name: 1H-pyrazolo[3,4-b]pyridine-3-carbonitrile
Packaging: 10g
Price: $887.1
Updated: 2021/12/16

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1H-pyrazolo[3,4-b]pyridine-3-carbonitrile Chemical Properties,Usage,Production

Uses

1H-pyrazolo[3,4-b]pyridine-3-carbonitrile can be used to prepare SGC stimulants for the treatment of central nervous system disorders.

Synthesis

956010-87-0

956010-88-1

General procedure for the synthesis of 1H-pyrazolo[3,4-b]pyridine-3-carbonitrile from 3-(trifluoromethyl)-1H-pyrazolo[3,4-B]pyridine: 3-(Trifluoromethyl)-1H-pyrazolo[3,4-B]pyridine (500 mg, 2.67 mmol) was suspended in 33% ammonia solution (10 mL). The mixture was placed in a sealed tube and heated to 140 °C using microwave and maintained for 10 min. Upon completion of the reaction, the volatiles were evaporated. Ethyl acetate (100 mL) and tert-butyl methyl ether (25 mL) were added to the residue and the mixture was heated to 70 °C. The mixture was filtered while hot and the residue was washed with tert-butyl methyl ether. The filtrates were combined and evaporated to afford 1H-pyrazolo[3,4-b]pyridine-3-carbonitrile as a light yellow solid (389 mg, 90% yield), with trace amounts of the corresponding primary amide in the product. The structure of the product was determined by 1H NMR (400 MHz, DMSO-d6): δ 7.47 (dd, J = 8.2,4.5 Hz, 1H), 8.46 (dd, J = 8.2,1.5 Hz, 1H), 8.73 (dd, J = 4.5,1.5 Hz, 1H), 15.02 (br s, 1H); 13C NMR (125 MHz. DMSO-d6): δ 113.5,115.5,116.9,119.6,128.7,150.9,151.0 confirmed. High-resolution mass spectrometry (HRMS) analysis results: calculated value C7H4N4 [M]+: 144.0436; measured value: 144.0430.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 5, p. 1197 - 1200
[2] Tetrahedron, 2015, vol. 71, # 34, p. 5597 - 5601
[3] Patent: US2010/113507, 2010, A1. Location in patent: Page/Page column 9
[4] Patent: US2010/4235, 2010, A1. Location in patent: Page/Page column 15

1H-pyrazolo[3,4-b]pyridine-3-carbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-pyrazolo[3,4-b]pyridine-3-carbonitrile Suppliers

China 84 India 2 United States 6 Global 92

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View Lastest Price from 1H-pyrazolo[3,4-b]pyridine-3-carbonitrile manufacturers

Honest Joy Holdings Limited

Product: 1H-Pyrazolo[3,4-b]pyridine-3-carbonitrile 956010-88-1
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.7%
Supply Ability: 100 tons
Release date: 2022-01-14

Career Henan Chemical Co

Product: 1H-pyrazolo[3,4-b]pyridine-3-carbonitrile 956010-88-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200kg
Release date: 2019-08-29

956010-88-1, 1H-pyrazolo[3,4-b]pyridine-3-carbonitrileRelated Search:

1H-pyrazolo[3,4-b]pyridine-3-carbonitrile

1H-pyrazolo[3

4-b]pyridine-3-carbonitrile

2H-pyrazolo[3,4-b]pyridine-3-carbonitrile

1H-pyrazole and [3, 4-b] pyridine-3-methyl nitrile

Piraxostat Impurity 30

956010-88-1