Ethyl 2-bromo-5-fluorobenzoate
- Product Name
- Ethyl 2-bromo-5-fluorobenzoate
- CAS No.
- 139911-28-7
- Chemical Name
- Ethyl 2-bromo-5-fluorobenzoate
- Synonyms
- 2-broMo-5-fluoroethyl benzoate;Ethyl 2-bromo-5-fluorobenzoate;ethyl 2-bromo-5-fluorobenzoatato;Benzoic acid, 2-bromo-5-fluoro-, ethyl ester
- CBNumber
- CB62501266
- Molecular Formula
- C9H8BrFO2
- Formula Weight
- 247.06
- MOL File
- 139911-28-7.mol
Ethyl 2-bromo-5-fluorobenzoate Property
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Colorless to light yellow Liquid
- InChI
- InChI=1S/C9H8BrFO2/c1-2-13-9(12)7-5-6(11)3-4-8(7)10/h3-5H,2H2,1H3
- InChIKey
- ODFAIHQRCRQZGM-UHFFFAOYSA-N
- SMILES
- C(OCC)(=O)C1=CC(F)=CC=C1Br
- EPA Substance Registry System
- Benzoic acid, 2-bromo-5-fluoro-, ethyl ester (139911-28-7)
Safety
- HS Code
- 2916399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- B124960
- Product name
- Ethyl2-Bromo-5-fluorobenzoate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 2623-B-32
- Product name
- Ethyl 2-bromo-5-fluorobenzoate
- Purity
- 97%
- Packaging
- 5G
- Price
- $69
- Updated
- 2021/12/16
- Product number
- 149564
- Product name
- Ethyl 2-bromo-5-fluorobenzoate
- Purity
- 95%
- Packaging
- 5g
- Price
- $78
- Updated
- 2021/12/16
- Product number
- J94437
- Product name
- Ethyl2-bromo-5-fluorobenzoate
- Packaging
- 10g
- Price
- $103
- Updated
- 2021/12/16
- Product number
- 149564
- Product name
- Ethyl 2-bromo-5-fluorobenzoate
- Purity
- 95%
- Packaging
- 25g
- Price
- $198
- Updated
- 2021/12/16
Ethyl 2-bromo-5-fluorobenzoate Chemical Properties,Usage,Production
Synthesis
451-02-5
139911-28-7
General procedure for the synthesis of ethyl 2-bromo-5-fluorobenzoate from ethyl m-fluorobenzoate: in a 100 mL round-bottomed flask, ethyl m-fluorobenzoate (1.68 g, 1.0 eq.), N-bromosuccinimide (NBS, 1.87 g, 1.05 eq.), palladium acetate (Pd(OAc)2, 78.5 mg, 0.035 eq.) and sodium persulfate ( Na2S2O8, 2.86 g, 1.2 eq.) were dissolved in 12 mL of commercially available dichloroethane. Subsequently, trifluoromethanesulfonic acid (TfOH, 2.2 mL, 2.5 eq.) was added to the reaction solution. The reaction mixture was stirred at 80°C for 9 hours. Upon completion of the reaction, the mixture was cooled to room temperature and saturated sodium bicarbonate (NaHCO3) solution was added to quench the reaction. The reaction mixture was diluted with dichloromethane and washed once with saturated aqueous NaHCO3 solution. The organic layer was dried with anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. Finally, the residue was purified by silica gel column chromatography to afford the target product ethyl 2-bromo-5-fluorobenzoate (1.71 g) in 70% yield.
References
[1] Chinese Chemical Letters, 2014, vol. 25, # 5, p. 667 - 669
Ethyl 2-bromo-5-fluorobenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl 2-bromo-5-fluorobenzoate manufacturers
- Product
- Ethyl 2-bromo-5-fluoro-benzoate 139911-28-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 50mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-08
- Product
- Ethyl 2-bromo-5-fluorobenzoate 139911-28-7
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2020-02-13