6-Dimethylaminopyridine-3-boronic acid pinacol ester

Product Name: 6-Dimethylaminopyridine-3-boronic acid pinacol ester
CAS No.: 1036991-24-8
Chemical Name: 6-Dimethylaminopyridine-3-boronic acid pinacol ester
Synonyms: 2-N, N-dimethylpyridine-4-borate frequency;6-Dimethylaminopyridine-3-boronic acid pinacol ester;2-(Dimethylamino)pyridine-5-boronic acid pinacol ester;N,N-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl);N,N-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinamine;2-Pyridinamine, N,N-dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-;N,N-dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinamine(SALTDATA: FREE)
CBNumber: CB62506009
Molecular Formula: C13H21BN2O2
Formula Weight: 248.13
MOL File: 1036991-24-8.mol

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6-Dimethylaminopyridine-3-boronic acid pinacol ester Property

Melting point:: 89-90 °C
Boiling point:: 358.5±27.0 °C(Predicted)
Density: 1.04±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 6.98±0.10(Predicted)
Appearance: Off-white to light yellow Solid

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Safety

Hazard Codes: Xi
Risk Statements: 43
Safety Statements: 36/37
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC

Product number: D479170
Product name: 6-(Dimethylamino)pyridine-3-boronicacidpinacolester
Packaging: 100mg
Price: $45
Updated: 2021/12/16

AK Scientific

Product number: Z3306
Product name: N,N-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinamine
Packaging: 1g
Price: $161
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: BOR0007327
Product name: N,N-DIMETHYL-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDIN-2-AMINE
Purity: 95.00%
Packaging: 1G
Price: $289.8
Updated: 2021/12/16

Ambeed

Product number: A268925
Product name: N,N-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine
Purity: 95+%
Packaging: 100mg
Price: $25
Updated: 2021/12/16

Ambeed

Product number: A268925
Product name: N,N-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine
Purity: 95+%
Packaging: 250mg
Price: $25
Updated: 2021/12/16

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6-Dimethylaminopyridine-3-boronic acid pinacol ester Chemical Properties,Usage,Production

Uses

6-(Dimethylamino)pyridine-3-boronic acid pinacol ester

Synthesis

26163-07-5

73183-34-3

1036991-24-8

General procedure for the synthesis of N,N-dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine from 5-bromo-N,N-dimethylpyridin-2-amine and pinacol bis(boronic acid) ester: Under nitrogen protection, potassium acetate (8.3 g, 42.3 mmol) and [1,1,7 mmol] were added to a solution of 5-bromo-N,N-dimethylpyridin-2-amine (8.5 g, 42.3 mmol) and pinacol bis(boronic acid) ester (12.9 g, 50.7 mmol) to a solution of dioxane (10 mL) was added potassium acetate (8.3 g, 84.6 mmol) and [1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloride (1.55 g, 2.1 mmol). The reaction mixture was stirred at 25°C and subsequently heated to 100°C and kept for 12 hours. The completion of the reaction was monitored by LCMS. After completion of the reaction, the mixture was filtered and the filtrate was concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate = 50/1 to 3/1) to afford the target compound 2-(2-(N,N-dimethylamino)pyridin-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolanes (8 g, 32.2 mmol, 76% yield) as yellow solid. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 8.53 (s, 1H), 7.75-7.78 (d, 1H), 6.43-6.45 (d, 1H), 3.09 (s, 6H), 1.22-1.30 (m, 12H).ESI-MS (m/z): 249.2 [M+H]+.

References

[1] Patent: WO2017/120429, 2017, A1. Location in patent: Page/Page column 262
[2] Advanced Synthesis and Catalysis, 2010, vol. 352, # 11-12, p. 2002 - 2010
[3] European Journal of Organic Chemistry, 2012, # 3, p. 595 - 603
[4] Patent: WO2017/98440, 2017, A1. Location in patent: Page/Page column 248

6-Dimethylaminopyridine-3-boronic acid pinacol ester Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Dimethylaminopyridine-3-boronic acid pinacol ester Suppliers

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View Lastest Price from 6-Dimethylaminopyridine-3-boronic acid pinacol ester manufacturers

Career Henan Chemical Co

Product: 6-Dimethylaminopyridine-3-boronic acid pinacol ester 1036991-24-8
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-02-11

Career Henan Chemical Co

Product: 6-Dimethylaminopyridine-3-boronic acid pinacol ester 1036991-24-8
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-02-11

1036991-24-8, 6-Dimethylaminopyridine-3-boronic acid pinacol esterRelated Search:

2-METHYLSULFANYL-5-(4,4,5,5-TETRAMETHYL-[1,3,2]-DIOXABOROLAN-2-YL)PYRIDINE 6-(4-MORPHOLINEAMINO)PYRIDINE-3-BORONIC ACID PINACOL ESTER 6-(4-MorpholinylMethyl)pyridine-3-boronic acid pinacol ester 2-(BENZYLAMINO)PYRIDINE-5-BORONIC ACID PINACOL ESTER 1-METHYL-4-[5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABORALAN-2-YL)PYRIDINE-2-YL]PIPERAZINE 6-(CYCLOHEXYLAMINO)PYRIDINE-3-BORONIC ACID PINACOL ESTER 6-(4-FLUOROPHENYL)PYRIDINE-3-BORONIC ACID PINACOL ESTER TERT-BUTYL N-METHYL-N-[5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDIN-2-YL]CARBAMATE 2-(4-METHYLBENZYLAMINO)PYRIDINE-5-BORONIC ACID PINACOL ESTER 4-[5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRIDIN-2-YL]-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER TERT-BUTYL N-METHYL-N-[3-METHYL-5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDIN-2-YL]CARBAMATE 2-(CYCLOPROPYLMETHOXY)-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE 5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRIDINE-2-CARBOXYLIC ACID DIETHYLAMIDE 2-Dimethylamino-pyrimidine-5-boronic acid pinacol ester

6-Dimethylaminopyridine-3-boronic acid pinacol ester

2-(Dimethylamino)pyridine-5-boronic acid pinacol ester

N,N-dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinamine(SALTDATA: FREE)

N,N-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinamine

N,N-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)

2-Pyridinamine, N,N-dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-

2-N, N-dimethylpyridine-4-borate frequency

1036991-24-8