tert-butyl 4,4-difluoropiperidine-1-carboxylate
- Product Name
- tert-butyl 4,4-difluoropiperidine-1-carboxylate
- CAS No.
- 281652-10-6
- Chemical Name
- tert-butyl 4,4-difluoropiperidine-1-carboxylate
- Synonyms
- 1-Boc-4,4-difluoropiperidine;tert-Butyl 4,4-difluoropiperidin-1-carboxylate;tert-butyl 4,4-difluoropiperidine-1-carboxylate;tert-Butyl 4,4-difluoro-1-piperidinecarboxylate;4,4-difluoropiperidine-1-formic acid tert-butyl ester;4,4-Difluoro-piperidine-1-carboxylic acid tert-butyl ester;1-Piperidinecarboxylic acid, 4,4-difluoro-, 1,1-dimethylethyl ester
- CBNumber
- CB62506100
- Molecular Formula
- C10H17F2NO2
- Formula Weight
- 221.24
- MOL File
- 281652-10-6.mol
tert-butyl 4,4-difluoropiperidine-1-carboxylate Property
- Boiling point:
- 247.7±40.0 °C(Predicted)
- Density
- 1.12±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- -4.70±0.40(Predicted)
- Appearance
- Off-white to light brown Solid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B809698
- Product name
- tert-Butyl4,4-Difluoropiperidine-1-carboxylate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 4H56-3-7H
- Product name
- tert-Butyl 4,4-difluoropiperidine-1-carboxylate
- Purity
- 97.0%
- Packaging
- 250mg
- Price
- $73
- Updated
- 2021/12/16
- Product number
- 4H56-3-7H
- Product name
- tert-Butyl 4,4-difluoropiperidine-1-carboxylate
- Purity
- 97.0%
- Packaging
- 1g
- Price
- $140
- Updated
- 2021/12/16
- Product number
- 4H56-3-7H
- Product name
- tert-Butyl 4,4-difluoropiperidine-1-carboxylate
- Purity
- 97.0%
- Packaging
- 5G
- Price
- $390
- Updated
- 2021/12/16
- Product number
- Y8550
- Product name
- tert-Butyl4,4-difluoro-1-piperidinecarboxylate
- Packaging
- 10g
- Price
- $431
- Updated
- 2021/12/16
tert-butyl 4,4-difluoropiperidine-1-carboxylate Chemical Properties,Usage,Production
Synthesis
79099-07-3
281652-10-6
General procedure: Example 1: Preparation of Intermediate 1: tert-butyl 4,4-difluoropiperidine-1-carboxylate To a solution of N-tert-butoxycarbonyl-4-piperidone (10 g; 0.05 mol) in anhydrous dichloromethane (80 ml) at 40 °C, diethylamino sulfur trifluoride (DAST, 3 eq.) was slowly added. The reaction mixture was stirred at 20 °C for 4 hours. Subsequently, the mixture was brought back to room temperature and carefully poured into saturated aqueous sodium bicarbonate solution. The aqueous phase was extracted with dichloromethane (3 x 70 ml) and the combined organic phases were washed with deionized water and dried over anhydrous sodium sulfate. After concentration under reduced pressure, a light yellow oily product was obtained in 95% yield. 1H NMR (CDCl3) δ: 3.52-3.58 (m, 4H), 1.87-2.0 (m, 4H), 1.49 (s, 9H).
References
[1] Patent: WO2013/127913, 2013, A1. Location in patent: Page/Page column 37; 38
[2] Patent: US2015/51226, 2015, A1. Location in patent: Paragraph 0182; 0183; 0184
[3] Patent: WO2017/149518, 2017, A1. Location in patent: Page/Page column 27; 28
[4] Patent: WO2015/52264, 2015, A1. Location in patent: Paragraph 01571; 01572
[5] Patent: WO2017/17630, 2017, A1. Location in patent: Page/Page column 54
tert-butyl 4,4-difluoropiperidine-1-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from tert-butyl 4,4-difluoropiperidine-1-carboxylate manufacturers
- Product
- tert-butyl 4,4-difluoropiperidine-1-carboxylate 281652-10-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 500kg
- Release date
- 2018-08-17
- Product
- tert-butyl 4,4-difluoropiperidine-1-carboxylate 281652-10-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 500kg
- Release date
- 2018-08-17