Aurora A Inhibitor I

Product Name: Aurora A Inhibitor I
CAS No.: 1158838-45-9
Chemical Name: Aurora A Inhibitor I
Synonyms: Aurora A-IN-10;Aurora A Inhibitor I;TCS7010, 10 mM in DMSO;TC-S 7010 Aurora A Inhibitor;Aurora A Inhibitor I USP/EP/BP;TC-S 7010 (Aurora A Inhibitor I);Aurora A Inhibitor I (TC-S 7010);Aurora-A Inhibitor I >=98% (HPLC);N-(2-Chlorophenyl)-4-((2-((4-(2-(4-ethylpiperazin-1-yl)-2-oxoethyl)-phenyl)amino)-5-fluoropyri;N-(2-Chlorophenyl)-4-((2-((4-(2-(4-ethylpiperazin-1-yl)-2-oxoethyl)-phenyl)amino)-5-fluoropyrimid
CBNumber: CB62506281
Molecular Formula: C31H31ClFN7O2
Formula Weight: 588.07
MOL File: 1158838-45-9.mol

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Aurora A Inhibitor I Property

Density: 1.362
storage temp.: 2-8°C
solubility: DMSO: soluble10mg/mL, clear
form: powder
color: white to beige
InChIKey: AKSIZPIFQAYJGF-UHFFFAOYSA-N

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0882
Product name: Aurora-A Inhibitor I
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $165
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0882
Product name: Aurora-A Inhibitor I
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $657
Updated: 2024/03/01

Cayman Chemical

Product number: 21600
Product name: Aurora A Inhibitor I
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 21600
Product name: Aurora A Inhibitor I
Purity: ≥98%
Packaging: 5mg
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 21600
Product name: Aurora A Inhibitor I
Purity: ≥98%
Packaging: 10mg
Price: $243
Updated: 2024/03/01

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Aurora A Inhibitor I Chemical Properties,Usage,Production

Uses

TC-S 7010 is a selective Aurora A inhibitor.

Definition

ChEBI: N-(2-chlorophenyl)-4-[[2-[4-[2-(4-ethyl-1-piperazinyl)-2-oxoethyl]anilino]-5-fluoro-4-pyrimidinyl]amino]benzamide is a member of benzamides.

Biological Activity

aurora a inhibitor i is a novel, potent, and selective inhibitor of aurora a .aurora kinases are reported to be required for mitosis and to complete cell division. because of this, aurora kinase inhibitors have been investigated extensively as potential anticancer therapeutic agents. the two major aurora kinases (aurora a and aurora b) are closely related in kinase domain sequence (71% identical).

in vitro

aurora a inhibitor i was tested against wild-type kinase and two mutants (aurora a (t217e) and aurora b (e161t)). the inhibitory potencies of aurora a inhibitor i was strongly affected by the single amino acid substitutions. for either aurora kinase, the presence of threonine allowed potent inhibition, while for glutamic acid variants, there was a approximately 100-fold shift in ic50, which supported the “gating” role for this residue. the aurora b binding pocket was enlarged by the e161t mutation, while the pocket in aurora a was closed by the t217e mutation. aurora a inhibitor i was exceptionally selective aurora a inhibitors, as shown by no inhibition on aurora b or cdks was observed in cellular assays [1].

IC 50

3.4 nm.

storage

Store at +4°C

References

[1] aliagas-martin i,burdick d,corson l,dotson j,drummond j,fields c,huang ow,hunsaker t,kleinheinz t,krueger e,liang j,moffat j,phillips g,pulk r,rawson te,ultsch m,walker l,wiesmann c,zhang b,zhu by,cochran ag. a class of 2,4-bisanilinopyrimidine aurora a inhibitors with unusually high selectivity against aurora b. j med chem.2009 may 28;52(10):3300-7.

Aurora A Inhibitor I Preparation Products And Raw materials

Raw materials

Preparation Products

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Aurora A Inhibitor I Suppliers

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1158838-45-9, Aurora A Inhibitor IRelated Search:

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Aurora A Inhibitor I

BenzaMide, N-(2-chlorophenyl)-4-[[2-[[4-[2-(4-ethyl-1-piperazinyl)-2-oxoethyl]phenyl]aMino]-5-fluoro-4-pyriMidinyl]aMino]-

N-(2-Chlorophenyl)-4-(2-(4-(2-(4-ethylpiperazin-1-yl)-2-oxoethyl)phenylamino)-5-fluoropyrimidin-4-ylamino)benzamide

N-(2-Chlorophenyl)-4-[[2-[[4-[2-(4-ethyl-1-piperazinyl)-2-oxoethyl]phenyl]amino]-5-fluoro-4-pyrimidinyl]amino]benzamide

N-(2-Chlorophenyl)-4-((2-((4-(2-(4-ethylpiperazin-1-yl)-2-oxoethyl)-phenyl)amino)-5-fluoropyrimid

N-(2-Chlorophenyl)-4-((2-((4-(2-(4-ethylpiperazin-1-yl)-2-oxoethyl)-phenyl)amino)-5-fluoropyri

Aurora A-IN-10

TC-S 7010 (Aurora A Inhibitor I)

Aurora-A Inhibitor I >=98% (HPLC)

Aurora A Inhibitor I USP/EP/BP

Aurora A Inhibitor I (TC-S 7010)

TC-S 7010 Aurora A Inhibitor

TCS7010, 10 mM in DMSO

1158838-45-9

C31H31ClFN7O2

Inhibitors