alpha-[[9-Methyl-2-(3-methylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]methylene]-2-benzothiazoleacetonitrile

Product Name: alpha-[[9-Methyl-2-(3-methylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]methylene]-2-benzothiazoleacetonitrile
CAS No.: 620112-78-9
Chemical Name: alpha-[[9-Methyl-2-(3-methylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]methylene]-2-benzothiazoleacetonitrile
Synonyms: CCG-63802;CCG 63802; CCG63802;(E)-2-(Benzo[d]thiazol-2-yl)-3-(9-methyl-4-oxo-2-(m-tolyloxy)-4H-pyrido[1,2-a]pyrimidin-3-yl)a;(E)-2-(Benzo[d]thiazol-2-yl)-3-(9-methyl-4-oxo-2-(m-tolyloxy)-4H-pyrido[1,2-a]pyrimidin-3-yl)acry;(E)-2-(Benzo[d]thiazol-2-yl)-3-(9-methyl-4-oxo-2-(m-tolyloxy)-4H-pyrido[1,2-a]pyrimidin-3-yl)acrylonitrile;α-[[9-Methyl-2-(3-methylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]methylene]-2-benzothiazoleacetonitrile;2-Benzothiazoleacetonitrile, α-[[9-methyl-2-(3-methylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]methylene]-;alpha-[[9-Methyl-2-(3-methylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]methylene]-2-benzothiazoleacetonitrile;(2E)-2-(1,3-Benzothiazol-2-yl)-3-[9-methyl-2-(3-methylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]acrylonitrile;CCG-63802,inflammation,RGS,reversible,selective,CCG63802,Regulator of G-protein Signaling,Regulators of G-protein Signaling,inhibit,Inhibitor,CCG 63802,RGS Protein
CBNumber: CB62509949
Molecular Formula: C26H18N4O2S
Formula Weight: 450.51
MOL File: 620112-78-9.mol

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alpha-[[9-Methyl-2-(3-methylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]methylene]-2-benzothiazoleacetonitrile Property

Boiling point:: 547.9±60.0 °C(Predicted)
Density: 1.31
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: Limited solubility, soluble in DMSO
form: solid
pka: -0.42±0.70(Predicted)
color: Yellow

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Tocris

Product number: 4028
Product name: CCG63802
Purity: ≥99%(HPLC)
Packaging: 10
Price: $215
Updated: 2021/12/16

Tocris

Product number: 4028
Product name: CCG63802
Purity: ≥99%(HPLC)
Packaging: 50
Price: $863
Updated: 2021/12/16

TRC

Product number: C227908
Product name: CCG63802
Packaging: 50mg
Price: $305
Updated: 2021/12/16

Usbiological

Product number: 254900
Product name: CCG 63802
Packaging: 10mg
Price: $466
Updated: 2021/12/16

ChemScene

Product number: CS-0040
Product name: CCG-63802
Purity: 98.38%
Packaging: 50mg
Price: $528
Updated: 2021/12/16

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alpha-[[9-Methyl-2-(3-methylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]methylene]-2-benzothiazoleacetonitrile Chemical Properties,Usage,Production

Biological Activity

CCG-63802 is a selective, reversible inhibitor of the G protein signaling regulator RGS4. It specifically binds to RGS4 and blocks RGS4-Gαo interaction with IC50 value of 1.9 μM.

in vitro

CCG-63802 (5 μM) inhibits regulators of G-protein signaling (RGS) proteins in the presence of BK (bradykinin) and 8-Br-cGMP (membrane-permeable analogue of cGMP), HEK-293 cells start to depolarize again.

in vivo

CCG-63802 (0.05 mg/kg; intratracheal administration; once per week; 90 days) reduces RGS4 protein expression, leading to partially abrogate the attenuating effect of PGZ on airway inflammation, hyperresponsiveness (AHR), and remodeling .

target

RGS4

1.9 μM (IC ₅₀ )

alpha-[[9-Methyl-2-(3-methylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]methylene]-2-benzothiazoleacetonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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alpha-[[9-Methyl-2-(3-methylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]methylene]-2-benzothiazoleacetonitrile Suppliers

China 40 United Kingdom 3 United States 15 Global 58

MedChemexpress LLC

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620112-78-9, alpha-[[9-Methyl-2-(3-methylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]methylene]-2-benzothiazoleacetonitrileRelated Search:

Benzyl vinyl ether

α-[[9-Methyl-2-(3-methylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]methylene]-2-benzothiazoleacetonitrile

(E)-2-(Benzo[d]thiazol-2-yl)-3-(9-methyl-4-oxo-2-(m-tolyloxy)-4H-pyrido[1,2-a]pyrimidin-3-yl)a

CCG-63802

(E)-2-(Benzo[d]thiazol-2-yl)-3-(9-methyl-4-oxo-2-(m-tolyloxy)-4H-pyrido[1,2-a]pyrimidin-3-yl)acry

alpha-[[9-Methyl-2-(3-methylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]methylene]-2-benzothiazoleacetonitrile

CCG 63802; CCG63802

(2E)-2-(1,3-Benzothiazol-2-yl)-3-[9-methyl-2-(3-methylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]acrylonitrile

2-Benzothiazoleacetonitrile, α-[[9-methyl-2-(3-methylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]methylene]-

(E)-2-(Benzo[d]thiazol-2-yl)-3-(9-methyl-4-oxo-2-(m-tolyloxy)-4H-pyrido[1,2-a]pyrimidin-3-yl)acrylonitrile

CCG-63802,inflammation,RGS,reversible,selective,CCG63802,Regulator of G-protein Signaling,Regulators of G-protein Signaling,inhibit,Inhibitor,CCG 63802,RGS Protein

620112-78-9