1,2,3,4-Tetrahydro-2-quinolinemethanol
- Product Name
- 1,2,3,4-Tetrahydro-2-quinolinemethanol
- CAS No.
- 40971-36-6
- Chemical Name
- 1,2,3,4-Tetrahydro-2-quinolinemethanol
- Synonyms
- (1,2,3,4-Tetrahydroquinolin-2-yl);1,2,3,4-Tetrahydro-2-quinolinemethanol;2-Quinolinemethanol, 1,2,3,4-tetrahydro-;(1,2,3,4-tetrahydroquinolin-2-yl)methanol;2-Hydroxymethyl-1,2,3,4-tetrahydroquinoline;(2S)-1,2,3,4-Tetrahydro-2-quinolinylMethanol
- CBNumber
- CB62510277
- Molecular Formula
- C10H13NO
- Formula Weight
- 163.22
- MOL File
- 40971-36-6.mol
1,2,3,4-Tetrahydro-2-quinolinemethanol Property
- Boiling point:
- 327.7±11.0 °C(Predicted)
- Density
- 1.081
- storage temp.
- 2-8°C
- pka
- 14.38±0.10(Predicted)
- Appearance
- Light yellow to yellow Viscous liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- X7072
- Product name
- 1,2,3,4-Tetrahydro-2-quinolinemethanol
- Packaging
- 100mg
- Price
- $196
- Updated
- 2021/12/16
- Product number
- P000222835
- Product name
- (1,2,3,4-Tetrahydroquinolin-2-yl)methanol
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $207
- Updated
- 2021/12/16
- Product number
- CHM0386630
- Product name
- (1,2,3,4-TETRAHYDROQUINOLIN-2-YL)METHANOL
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.42
- Updated
- 2021/12/16
- Product number
- P000222835
- Product name
- (1,2,3,4-Tetrahydroquinolin-2-yl)methanol
- Purity
- 95+%
- Packaging
- 1g
- Price
- $519
- Updated
- 2021/12/16
- Product number
- P000222835
- Product name
- (1,2,3,4-Tetrahydroquinolin-2-yl)methanol
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $119
- Updated
- 2021/12/16
1,2,3,4-Tetrahydro-2-quinolinemethanol Chemical Properties,Usage,Production
Synthesis
4620-34-2
63430-96-6
The general procedure for the synthesis of (S)-(1,2,3,4-tetrahydroquinoline-2-yl)methanol from ethyl 1,2,3,4-tetrahydroquinoline-2-carboxylate was as follows: at 0 °C, a tetrahydrofuran solution (5 ml/mmol) of ethyl 1,2,3,4-tetrahydroquinoline-2-carboxylate (25 mmol) was slowly added dropwise to a lithium aluminium hydroxide (2 equiv) tetrahydrofuran suspension (50 ml). The reaction mixture was stirred at 25°C for 1 hr and then warmed up to reflux to continue the reaction for 4 hr. The reaction progress was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction was quenched by slow addition of saturated sodium sulfate solution to the mixture, followed by filtration through diatomaceous earth and washing of the filter cake with ethyl acetate. After combining the filtrates, the solvents were removed by concentration under reduced pressure and the resulting crude product was purified by column chromatography (eluent ratio 3:7 ethyl acetate/hexane). The yield of the final product was 50%.
References
[1] Patent: US2008/153843, 2008, A1. Location in patent: Page/Page column 77
[2] Patent: US2008/249128, 2008, A1. Location in patent: Page/Page column 42
[3] Patent: US2008/306084, 2008, A1. Location in patent: Page/Page column 56
[4] Patent: WO2009/90055, 2009, A1. Location in patent: Page/Page column 90
[5] Patent: US2009/253669, 2009, A1. Location in patent: Page/Page column 44-45
1,2,3,4-Tetrahydro-2-quinolinemethanol Preparation Products And Raw materials
Raw materials
Preparation Products
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