(S)-tert-butyl 2-(1H-imidazol-2-yl)pyrrolidine-1-carboxylate
- Product Name
- (S)-tert-butyl 2-(1H-imidazol-2-yl)pyrrolidine-1-carboxylate
- CAS No.
- 1007882-58-7
- Chemical Name
- (S)-tert-butyl 2-(1H-imidazol-2-yl)pyrrolidine-1-carboxylate
- Synonyms
- tert-Butyl (S)-2-(1H-imidazol-2-yl)pyrrolidine-1-carboxylate;EOS-61042;-tert-Butyl 2-(1H-imidazol-2-yl);(S)-1-Boc-2-(2-imidazolyl)pyrrolidine;(S)-tert-butyl 2-(1H-imidazol-2-yl)pyrrolidine-1-carboxylate;tert-Butyl (2S)-2-(1H-imidazol-2-yl)pyrrolidine-1-carboxylate;1-Pyrrolidinecarboxylic acid, 2-(1H-imidazol-2-yl)-, 1,1-dimethylethyl ester, (2S)-
- CBNumber
- CB62513854
- Molecular Formula
- C12H19N3O2
- Formula Weight
- 237.3
- MOL File
- 1007882-58-7.mol
(S)-tert-butyl 2-(1H-imidazol-2-yl)pyrrolidine-1-carboxylate Property
- Boiling point:
- 422.6±38.0 °C(Predicted)
- Density
- 1.170±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 13.85±0.10(Predicted)
- Appearance
- Off-white to gray Solid
- optical activity
- -155.66°(C=1.0025 g/100ml CHCL3)
- InChI
- InChI=1S/C12H19N3O2/c1-12(2,3)17-11(16)15-8-4-5-9(15)10-13-6-7-14-10/h6-7,9H,4-5,8H2,1-3H3,(H,13,14)/t9-/m0/s1
- InChIKey
- GHITWFDHFOLATC-VIFPVBQESA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CCC[C@H]1C1NC=CN=1
N-Bromosuccinimide Price
- Product number
- CM187712
- Product name
- (S)-tert-Butyl2-(1H-imidazol-2-yl)pyrrolidine-1-carboxylate
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- CD11368048
- Product name
- (S)-tert-Butyl2-(1H-imidazol-2-yl)pyrrolidine-1-carboxylate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $119
- Updated
- 2021/12/16
- Product number
- CM187712
- Product name
- (S)-tert-Butyl2-(1H-imidazol-2-yl)pyrrolidine-1-carboxylate
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $124
- Updated
- 2021/12/16
- Product number
- CM187712
- Product name
- (S)-tert-Butyl2-(1H-imidazol-2-yl)pyrrolidine-1-carboxylate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $187
- Updated
- 2021/12/16
- Product number
- CD11368048
- Product name
- (S)-tert-Butyl2-(1H-imidazol-2-yl)pyrrolidine-1-carboxylate
- Purity
- 95+%
- Packaging
- 5g
- Price
- $356
- Updated
- 2021/12/16
(S)-tert-butyl 2-(1H-imidazol-2-yl)pyrrolidine-1-carboxylate Chemical Properties,Usage,Production
Synthesis
15761-39-4
1007882-58-7
General procedure for the synthesis of tert-butyl (S)-2-(1H-imidazol-2-yl)pyrrolidine-1-carboxylate from BOC-L-proline: 1. N-Boc-L-proline (10 g, 50.2 mmol) was dissolved in methanol (100 ml). 2. To the above solution, glyoxal (40% w/w aqueous solution, 25 g, 170.6 mmol) and ammonia (5N aqueous solution, 191 ml, 954 mmol) were added sequentially. 3. The reaction mixture was stirred at room temperature overnight. 4. After completion of the reaction, the reaction mixture was partitioned with dichloromethane and water. 5. The aqueous phase was extracted twice with dichloromethane. 6. The organic phases were combined and concentrated by evaporation under vacuum. 7. The residue was purified by rapid column chromatography on silica gel (methanol/dichloromethane, 0 to 3% gradient, then held at 3%) to afford tert-butyl (S)-2-(1H-imidazol-2-yl)pyrrolidine-1-carboxylate (9.87 g, 82% yield) as an off-white solid. ESI-LCMS m/e Calculated value: C12H19N3O2 [M+] 237.1, measured value: 237.9 [M+H+].
References
[1] Patent: US2012/230951, 2012, A1. Location in patent: Page/Page column 101
[2] Patent: WO2011/15657, 2011, A1
[3] Patent: WO2011/54834, 2011, A1
[4] Patent: US2012/136027, 2012, A1
[5] Patent: WO2014/19344, 2014, A1
(S)-tert-butyl 2-(1H-imidazol-2-yl)pyrrolidine-1-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (S)-tert-butyl 2-(1H-imidazol-2-yl)pyrrolidine-1-carboxylate manufacturers
- Product
- (S)-TERT-BUTYL 2-(1H-IMIDAZOL-2-YL)PYRROLIDINE-1-CARBOXYLATE 1007882-58-7
- Price
- US $1.10-9.90/KG
- Min. Order
- 1KG
- Purity
- 99%min
- Supply Ability
- 100KG
- Release date
- 2025-08-20
- Product
- (S)-tert-Butyl 2-(1H-imidazol-2-yl)pyrrolidine-1-carboxylate 1007882-58-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%HPLC
- Supply Ability
- 500kg
- Release date
- 2023-12-01