ChemicalBook > CAS DataBase List > N-Benzyl-3-pyrrolidinol

N-Benzyl-3-pyrrolidinol

Product Name
N-Benzyl-3-pyrrolidinol
CAS No.
775-15-5
Chemical Name
N-Benzyl-3-pyrrolidinol
Synonyms
idin-3-oL;N-benzyl-3-pyrrolitol;N-BENZYL-3-PYRROLIDINOL;1-BENZYL-3-PYRROLIDINOL;1-BENZYLPYRROLIDINE-3-OL;1-(benzyl)pyrrolidin-3-ol;1-Benzyl-3-pyrrolidinol >1-Benzyl-3-hydroxypyrrolidin;1-Phenylmethylpyrrolidin-3-ol;1-BENZYL-3-HYDROXYPYRROLIDINE
CBNumber
CB6251709
Molecular Formula
C11H15NO
Formula Weight
177.24
MOL File
775-15-5.mol
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N-Benzyl-3-pyrrolidinol Property

Boiling point:
113-115 °C2 mm Hg(lit.)
Density 
1.07 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.548(lit.)
Flash point:
>230 °F
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
14.82±0.20(Predicted)
form 
clear liquid
color 
Colorless to Light yellow to Light orange
BRN 
6039
InChI
InChI=1S/C11H15NO/c13-11-6-7-12(9-11)8-10-4-2-1-3-5-10/h1-5,11,13H,6-9H2
InChIKey
YQMXOIAIYXXXEE-UHFFFAOYSA-N
SMILES
N1(CC2=CC=CC=C2)CCC(O)C1
CAS DataBase Reference
775-15-5(CAS DataBase Reference)
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Safety

Hazard Codes 
T,Xi
Risk Statements 
25-36/37/38
Safety Statements 
26-36
RIDADR 
UN 2810 6.1/PG 3
WGK Germany 
1
F 
10-34
HazardClass 
6.1
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
302821
Product name
1-Benzyl-3-pyrrolidinol
Purity
95%
Packaging
5g
Price
$46.8
Updated
2023/06/20
Sigma-Aldrich
Product number
302821
Product name
1-Benzyl-3-pyrrolidinol
Purity
95%
Packaging
25g
Price
$73.5
Updated
2023/06/20
TCI Chemical
Product number
B1597
Product name
1-Benzyl-3-pyrrolidinol
Purity
>96.0%(GC)
Packaging
5g
Price
$25
Updated
2025/07/31
TCI Chemical
Product number
B1597
Product name
1-Benzyl-3-pyrrolidinol
Purity
>96.0%(GC)
Packaging
25g
Price
$70
Updated
2025/07/31
Chem-Impex
Product number
43857
Product name
1-Benzyl-3-pyrrolidinol,≥96%(GC)Hazmat
Purity
≥96%(GC)
Packaging
5G
Price
$23.11
Updated
2021/12/16
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N-Benzyl-3-pyrrolidinol Chemical Properties,Usage,Production

Uses

1-Benzyl-3-pyrrolidinol was used in preparation of:

  • potent calcium antagonist, 1-benzyl-3-pyrrolidinyl methyl 2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • (3R)-1-benzyl-3-methanesulfonyloxy pyrrolidine

Synthesis Reference(s)

The Journal of Organic Chemistry, 51, p. 4296, 1986 DOI: 10.1021/jo00372a038

Synthesis

2419-74-1

100-46-9

775-15-5

The present embodiment is a method for the preparation of N-benzyl-3-hydroxypyrrolidine, which was carried out as follows: 250 g of 40 wt% aqueous benzylamine solution was added to a 500 mL four-necked flask and cooled to 10 °C. In an ice water bath, 102 g of 1,4-dichloro-2-butanol was added dropwise while stirring and the temperature was controlled at 15 °C. After the dropwise addition was completed in about 15 min, the system was transferred to a 500 mL autoclave, sealed, evacuated to a pressure of 1.0 ± 0.1 MPa, and simultaneously heated to 120 ± 2 °C, and the reaction was stirred for about 10 h. The disappearance of the raw material was monitored by GC. At the end of the reaction, cooled to room temperature, the material was discharged, 110g of sodium hydroxide was added in batches, and the temperature was controlled to be lower than 50°C in order to release the methylamine gas and precipitate a large amount of white solids, stirring for 1h. After filtration, the filtrate was stratified, and the upper organic phase was treated with 100mL of ethanol and 18g of anhydrous magnesium sulphate, stirring for 2-3h. It was filtered again, and the filtrate was concentrated under vacuum to get a yellow transparent oily liquid, and finally By vacuum distillation, 46.7 g of colorless and transparent N-benzyl-3-hydroxypyrrolidine was obtained with 64.8% yield and 99.3% purity (HPLC).

References

[1] Patent: CN106631956, 2017, A. Location in patent: Paragraph 0022; 0023; 0024; 0025; 0026; 0027

N-Benzyl-3-pyrrolidinol Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Benzyl-3-pyrrolidinol Suppliers

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View Lastest Price from N-Benzyl-3-pyrrolidinol manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
N-Benzyl-3-pyrrolidinol 775-15-5
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-01-16
Shijiazhuang Gantuo Biotechnology Co., Ltd
Product
1-Benzyl-3-pyrrolidinol 775-15-5
Price
US $100.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000kg
Release date
2021-11-12
Qiuxian Baitai New Material Co., LTD
Product
N-Benzyl-3-pyrrolidinol 775-15-5
Price
US $55.00/g
Min. Order
1KG
Purity
99%
Supply Ability
5ton/Month
Release date
2021-12-15

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