QS11
- Product Name
- QS11
- CAS No.
- 944328-88-5
- Chemical Name
- QS11
- Synonyms
- QS11;CS-346;BML-WN117;QS11 hydrate;QS11;BML-WN117;Wnt Synergist, QS11;QS11, ARFGAP1 inhibitor;Wnt Synergist, QS11 - CAS 944328-88-5 - Calbiochem;(S)-2-((9-([1,1'-Biphenyl]-4-ylmethyl)-2-((2,3-dihydro-1H-inden-5-yl)oxy)-9H-purin-6-yl)amino);(2S)-2-[2-(Indan-5-yloxy)-9-(1,1'-biphenyl-4-yl)methyl)-9H-purin-6-ylamino]-3-phenyl-propan-1-ol
- CBNumber
- CB62517933
- Molecular Formula
- C36H33N5O2
- Formula Weight
- 567.69
- MOL File
- 944328-88-5.mol
QS11 Property
- Boiling point:
- 852.2±75.0 °C(Predicted)
- Density
- 1.27
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- solubility
- Soluble in DMSO
- form
- Pale amber solid
- pka
- 14.46±0.10(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 681668
- Product name
- Wnt Synergist, QS11
- Purity
- A cell-permeable purine compound that binds ARFGAPs (
- Packaging
- 5mg
- Price
- $575
- Updated
- 2024/03/01
- Product number
- 21247
- Product name
- QS11
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 21247
- Product name
- QS11
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $139
- Updated
- 2024/03/01
- Product number
- 21247
- Product name
- QS11
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $230
- Updated
- 2024/03/01
- Product number
- 21247
- Product name
- QS11
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $533
- Updated
- 2024/03/01
QS11 Chemical Properties,Usage,Production
Description
QS11 is an inhibitor of GTPase activating protein of ADP-ribosylation factors (ARFGAPs) that increases activity of ARFs in NIH3T3 cells at a concentration of 1 μM. It activates Wnt/β-catenin activity in a reporter assay using HEK293 cells (EC50 = 0.5 μM). QS11 exhibits synergy with Wnt-3a ligand-conditioned media, inducing a 200-fold increase in reporter activity compared to 40- and 2-fold increases observed with Wnt-3a ligand-conditioned media alone or QS11 treatment alone, respectively. It inhibits ARFGAP1 with an EC50 value of 1.5 μM in an enzyme assay and inhibits the migration of MDA-MB-231 breast cancer cells that overexpress AMAP1, an ARFGAP essential to cellular invasiveness.
Uses
QS 11 is a small molecule Wnt synergistic agonist.
Definition
ChEBI: (2S)-2-[[2-(2,3-dihydro-1H-inden-5-yloxy)-9-[(4-phenylphenyl)methyl]-6-purinyl]amino]-3-phenyl-1-propanol is a member of biphenyls.
in vitro
qs11 showed potent wnt synergist activity with little cytotoxicity in hek293 cells (ec50 = 0.5 μm) and human primary fibroblast cells (ec50 ≥ 10 μm). qs11 at 2.5 μm activated the super(8x)topflash reporter ~200-fold in the presence of wnt-3a conditioned medium. synergistic effect was also observed when qs11 was combined with recombinant wnt-3a protein (10–200 ng/ml) [2].
in vivo
in wnt signaling test model, embryos were injected with qs11, xwnt-8 rna or a combination of qs11and xwnt-8 rna. compared with qs11 alone and xwnt-8 rna alone, injection of a combination of xwnt-8 rna and qs11 induced significantly more full (20.9%) and partial (30.2%) double axis formation [2]..
storage
Store at +4°C
References
[1] singh mk1, gao h1, sun w1, song z1, schmalzigaug r2, premont rt2, zhang q3. structure-activity relationship studies of qs11, a small molecule wnt synergistic agonist. bioorg med chem lett. 2015 nov 1;25(21):4838-42.
[2] zhang q1, major mb, takanashi s, camp nd, nishiya n, peters ec, ginsberg mh, jian x, randazzo pa, schultz pg, moon rt, ding s. small-molecule synergist of the wnt/beta-catenin signaling pathway. proc natl acad sci u s a. 2007 may 1;104(18):7444-8. epub 2007 apr 25.
QS11 Preparation Products And Raw materials
Raw materials
Preparation Products
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