ChemicalBook > CAS DataBase List > 6-Trifluoromethylpyridazin-3(2H)-one

6-Trifluoromethylpyridazin-3(2H)-one

Product Name
6-Trifluoromethylpyridazin-3(2H)-one
CAS No.
174607-36-4
Chemical Name
6-Trifluoromethylpyridazin-3(2H)-one
Synonyms
6-Trifluoromethyl-pyridazin-3-ol;6-Trifluoromethylpyridazin-3(2H)-one;6-(Trifluoromethyl)pyridazin-3(2h)-on;3-(trifluoromethyl)-1H-pyridazin-6-one;3(2H)-Pyridazinone, 6-(trifluoromethyl)-;6-(trifluoroMethyl)-2,3-dihydropyridazin-3-one
CBNumber
CB62518228
Molecular Formula
C5H3F3N2O
Formula Weight
164.09
MOL File
174607-36-4.mol
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6-Trifluoromethylpyridazin-3(2H)-one Property

Melting point:
80-81 °C
Density 
1.55±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
pka
10.05±0.40(Predicted)
Appearance
White to light yellow Solid
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
T898898
Product name
6-(Trifluoromethyl)pyridazin-3(2H)-one
Packaging
10mg
Price
$45
Updated
2021/12/16
Apolloscientific
Product number
PC904495
Product name
6-(Trifluoromethyl)pyridazin-3(2H)-one
Purity
95%
Packaging
100mg
Price
$110
Updated
2021/12/16
Apolloscientific
Product number
PC904495
Product name
6-(Trifluoromethyl)pyridazin-3(2H)-one
Purity
95%
Packaging
250mg
Price
$175
Updated
2021/12/16
ChemScene
Product number
CS-W019009
Product name
6-(Trifluoromethyl)pyridazin-3(2H)-one
Packaging
1g
Price
$215
Updated
2021/12/16
Apolloscientific
Product number
PC904495
Product name
6-(Trifluoromethyl)pyridazin-3(2H)-one
Purity
95%
Packaging
1g
Price
$445
Updated
2021/12/16
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6-Trifluoromethylpyridazin-3(2H)-one Chemical Properties,Usage,Production

Synthesis

628332-15-0

174607-36-4

General procedure for the synthesis of 6-(trifluoromethyl)-4,5-dihydropyridazin-3(2H)-one from 6-(trifluoromethyl)-4,5-dihydropyridazin-3(2H)-one: a mixture of 6-(trifluoromethyl)-4,5-dihydropyridazin-3(2H)-one (90.0 g), bromine (30.5 mL), and acetic acid (270 mL) were stirred and reacted for 1 hour at 80 °C. Upon completion of the reaction, ice water (500 mL) was added to the reaction mixture to quench the reaction. The precipitated crystals were collected by filtration, washed sequentially with aqueous sodium bicarbonate and distilled water, and dried to give 6-(trifluoromethyl)pyridazin-3(2H)-one (58.74 g, 66% yield) as white crystals. The melting point of the product was 129-130 °C. 1H-NMR (CDCl3) δ: 7.14 (1H, dd, J = 9.9, 0.5 Hz), 7.54 (1H, d, J = 10.0 Hz), 12.64 (1H, brs).

References

[1] Tetrahedron, 2009, vol. 65, # 21, p. 4212 - 4219
[2] Patent: WO2003/99793, 2003, A1. Location in patent: Page 272
[3] Patent: US2011/34450, 2011, A1. Location in patent: Page/Page column 103
[4] Patent: WO2005/47279, 2005, A1. Location in patent: Page/Page column 48-49

6-Trifluoromethylpyridazin-3(2H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Trifluoromethylpyridazin-3(2H)-one Suppliers

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View Lastest Price from 6-Trifluoromethylpyridazin-3(2H)-one manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
6-(Trifluoromethyl)pyridazin-3(2H)-one 174607-36-4
Price
US $1.60-9.60/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-06-20
Shanghai Rlavie Technology Co ltd
Product
6-(trifluoromethyl)-2,3-dihydropyridazin-3-one 174607-36-4
Price
US $0.00/kg
Min. Order
0.0001kg
Purity
98%minHPLC
Supply Ability
25kgs/month
Release date
2022-06-07
Career Henan Chemical Co
Product
6-Trifluoromethylpyridazin-3(2H)-one 174607-36-4
Price
US $1.00/KG
Min. Order
1KG
Purity
97%
Supply Ability
200KG
Release date
2018-08-15

174607-36-4, 6-Trifluoromethylpyridazin-3(2H)-oneRelated Search:


  • 6-Trifluoromethylpyridazin-3(2H)-one
  • 6-(Trifluoromethyl)pyridazin-3(2h)-on
  • 6-(trifluoroMethyl)-2,3-dihydropyridazin-3-one
  • 6-Trifluoromethyl-pyridazin-3-ol
  • 3(2H)-Pyridazinone, 6-(trifluoromethyl)-
  • 3-(trifluoromethyl)-1H-pyridazin-6-one
  • 174607-36-4