ChemicalBook > CAS DataBase List > AMG-47a

AMG-47a

Product Name
AMG-47a
CAS No.
882663-88-9
Chemical Name
AMG-47a
Synonyms
AMG-47;CS-1025;AMG-47a;AMG-47a/AMG-47;AMG47A; GENETICIN;AMG 47;AMG-47;AMG47;AMG-47a, 10 mM in DMSO;4-Methyl-3-(2-((2-morpholinoethyl)amino)quinazolin-6-yl)-N-(3-(trifluoromethyl)phenyl)benzamid;4-methyl-3-(2-((2-morpholinoethyl)amino)quinazolin-6-yl)-N-(3-(trifluoromethyl)phenyl)benzamide; 4-methyl-3-[2-(2-morpholin-4-ylethylamino)quinazolin-6-yl]-N-[3-(trifluoromethyl)phenyl]benzamide
CBNumber
CB62518273
Molecular Formula
C29H28F3N5O2
Formula Weight
535.56
MOL File
882663-88-9.mol
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AMG-47a Property

Density 
1.324
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Powder
pka
13.23±0.70(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
25339
Product name
AMG 47a
Purity
≥98%
Packaging
5mg
Price
$121
Updated
2024/03/01
Cayman Chemical
Product number
25339
Product name
AMG 47a
Purity
≥98%
Packaging
10mg
Price
$207
Updated
2024/03/01
Cayman Chemical
Product number
25339
Product name
AMG 47a
Purity
≥98%
Packaging
25mg
Price
$481
Updated
2024/03/01
Cayman Chemical
Product number
25339
Product name
AMG 47a
Purity
≥98%
Packaging
50mg
Price
$903
Updated
2024/03/01
TRC
Product number
A614438
Product name
AMG-47a
Packaging
5mg
Price
$140
Updated
2021/12/16
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AMG-47a Chemical Properties,Usage,Production

Description

AMG 47a is an orally bioavailable inhibitor of Lck, VEGF receptor 2 (VEGFR2/KDR), p38α, and JAK3 (IC50s = 0.2, 1, 3, and 72 nM, respectively). It is selective for these kinases over a panel of additional kinases including SYK, JNK1, and PKAβ (IC50s = 292 to >25,000 nM) but does inhibit Src (IC50 = 2 nM). It decreases IL-2, but not TNF-α, production induced by an anti-CD3 antibody in 50% whole blood and inhibits T cell proliferation in vitro in a mixed lymphocyte reaction assay (IC50 = 30 nM). AMG 47a (10, 30, and 100 mg/kg) has anti-inflammatory activity, decreasing production of IL-2 induced by an anti-CD3 antibody in mice. It also decreases levels of mutant oncogene KRASG12V in HeLa cells in a reporter assay when used at a concentration of 1 μM.

Uses

AMG-47a is a inhibitor of lymphocyte-specific kinase (Lck), which is a cytoplasmic tyrosine kinase of the Src family expressed in T cells and natural killer (NK) cells.

References

1. carver j, dexheimer ts, hsu d et al. a high-throughput assay for small molecule destabilizers of the krasoncoprotein. plos one. 2014 aug 5;9(8):e103836.

AMG-47a Preparation Products And Raw materials

Raw materials

Preparation Products

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AMG-47a Suppliers

China 77 India 2 United Kingdom 1 United States 15 Global 95
BOC Sciences
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1-631-485-4226; 16314854226
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United States
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TargetMol Chemicals Inc.
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+1-781-999-5354 +1-00000000000
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Cckinase, Inc.
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Cayman Chemical Company
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Matrix Scientific
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View Lastest Price from AMG-47a manufacturers

Career Henan Chemical Co
Product
4-methyl-3-[2-(2-morpholin-4-ylethylamino)quinazolin-6-yl]-N-[3-(trifluoromethyl)phenyl]benzamide 882663-88-9
Price
US $1.00/KG
Min. Order
1g
Purity
Min98% HPLC
Supply Ability
g/kg /ton
Release date
2019-12-20

882663-88-9, AMG-47aRelated Search:


  • AMG47A; GENETICIN
  • AMG-47a
  • AMG-47
  • 4-Methyl-3-[2-[[2-(4-morpholinyl)ethyl]amino]-6-quinazolinyl]-N-[3-(trifluoromethyl)phenyl]benzamide
  • 4-Methyl-3-[2-[[2-(4-morpholinyl)ethyl]amino]-6-quinazolinyl]-N-[3-(trifluoromethyl)phenyl]benzamide AMG-47A
  • 4-Methyl-3-(2-((2-morpholinoethyl)amino)quinazolin-6-yl)-N-(3-(trifluoromethyl)phenyl)benzamid
  • 4-methyl-3-(2-((2-morpholinoethyl)amino)quinazolin-6-yl)-N-(3-(trifluoromethyl)phenyl)benzamide
  • CS-1025
  • AMG 47;AMG-47;AMG47
  • 4-methyl-3-[2-(2-morpholin-4-ylethylamino)quinazolin-6-yl]-N-[3-(trifluoromethyl)phenyl]benzamide
  • Benzamide, 4-methyl-3-[2-[[2-(4-morpholinyl)ethyl]amino]-6-quinazolinyl]-N-[3-(trifluoromethyl)phenyl]-
  • AMG-47a/AMG-47
  • AMG-47a, 10 mM in DMSO
  • 882663-88-9
  • C29H28F3N5O2
  • APIs