PF-04457845

ChemicalBook > CAS DataBase List > PF-04457845

Product Name: PF-04457845
CAS No.: 1020315-31-4
Chemical Name: PF-04457845
Synonyms: CS-1549;PF-04457845;PF-04457845;PF04457845;PF-04457845 >=98% (HPLC);Fatty acid amide hydrolase,Autophagy,inhibit,PF-04457845,FAAH,Inhibitor;N-Pyridazin-3-yl-4-(3-{[5-(trifluoroMethyl)pyridin-2-yl]oxy}benzylidene)piperidine-1-carboxaMide;N-3-Pyridazinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methylene]-1-piperidinecarboxamide;N-pyridazin-3-yl-4-[[3-[5-(trifluoromethyl)pyridin-2-yl]oxyphenyl]methylidene]piperidine-1-carboxamide;1-Piperidinecarboxamide, n-3-pyridazinyl-4-[[3-[[5-(trifluoromethyl)-2- pyridinyl]oxy]phenyl]methylene]-
CBNumber: CB62522724
Molecular Formula: C23H20F3N5O2
Formula Weight: 455.43
MOL File: 1020315-31-4.mol

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PF-04457845 Property

Boiling point:: 687.0±55.0 °C(Predicted)
Density: 1.389±0.06 g/cm3(Predicted)
storage temp.: room temp
solubility: DMF: 25 mg/ml; DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml; DMSO: 20 mg/ml; Ethanol: 5 mg/ml
form: powder
pka: 12.72±0.20(Predicted)
color: white to beige

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PZ0184
Product name: PF-04457845
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $108
Updated: 2023/06/20

Sigma-Aldrich

Product number: PZ0184
Product name: PF-04457845
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $438
Updated: 2023/06/20

Cayman Chemical

Product number: 19306
Product name: PF-04457845
Purity: ≥98%
Packaging: 5mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 19306
Product name: PF-04457845
Purity: ≥98%
Packaging: 10mg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 19306
Product name: PF-04457845
Purity: ≥98%
Packaging: 25mg
Price: $286
Updated: 2024/03/01

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PF-04457845 Chemical Properties,Usage,Production

Biochem/physiol Actions

PF-04457845 is a potent, orally active, irreversible inhibitor of fatty acid amide hydrolase (FAAH), the principle enzyme involved in the degradation of the endocannabinoid anandamide. PF-04457845 is a covalent inhibitor that carbamylates FAAH′s serine nucleophile. It was shown to be both potent and selective against other serine hydrolases. It has an IC50 value of 7.2 nM for human FAAH. The endocannabinoid system is a target for therapeutic pain relief. In a rat model of inflammatory pain, PF-04457845 produced significant reduction of inflammatory pain with efficacy comparable to that of naproxen at 10 mg/kg.

storage

Store at +4°C

PF-04457845 Preparation Products And Raw materials

Raw materials

Preparation Products

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PF-04457845 Suppliers

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1020315-31-4, PF-04457845Related Search:

N-3-Pyridazinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methylene]-1-piperidinecarboxamide

PF-04457845

N-Pyridazin-3-yl-4-(3-{[5-(trifluoroMethyl)pyridin-2-yl]oxy}benzylidene)piperidine-1-carboxaMide

PF-04457845;PF04457845

1-Piperidinecarboxamide, n-3-pyridazinyl-4-[[3-[[5-(trifluoromethyl)-2- pyridinyl]oxy]phenyl]methylene]-

N-pyridazin-3-yl-4-[[3-[5-(trifluoromethyl)pyridin-2-yl]oxyphenyl]methylidene]piperidine-1-carboxamide

CS-1549

PF-04457845 >=98% (HPLC)

Fatty acid amide hydrolase,Autophagy,inhibit,PF-04457845,FAAH,Inhibitor

1020315-31-4

C23H20F3N5O2