ChemicalBook > CAS DataBase List > 1,3-Benzodioxole-5-carboxylic acid, 7-hydroxy-, methyl ester

1,3-Benzodioxole-5-carboxylic acid, 7-hydroxy-, methyl ester

Product Name
1,3-Benzodioxole-5-carboxylic acid, 7-hydroxy-, methyl ester
CAS No.
116119-01-8
Chemical Name
1,3-Benzodioxole-5-carboxylic acid, 7-hydroxy-, methyl ester
Synonyms
Methyl 3,4-Methylenedioxy-5-hydroxybenzoate;methyl 7-hydroxy-1,3-benzodioxole-5-carboxylate;methyl 7-hydroxy-2H-1,3-benzodioxole-5-carboxylate;Methyl 7-hydroxybenzo[d][1,3]dioxole-5-carboxylate;7-Hydroxy-1,3-benzodioxole-5-carboxylic Acid Methyl Ester;1,3-Benzodioxole-5-carboxylic acid, 7-hydroxy-, methyl ester;7-Hydroxy-1,3-benzodioxole-5-carboxylic Acid Methyl Ester, CAS 116119-01-8
CBNumber
CB62522890
Molecular Formula
C9H8O5
Formula Weight
196.16
MOL File
116119-01-8.mol
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1,3-Benzodioxole-5-carboxylic acid, 7-hydroxy-, methyl ester Property

storage temp. 
Inert atmosphere,Room Temperature
solubility 
CDCl3, DCM, Ethanol, Ethyl Acetate,
form 
Solid
color 
White
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
H808470
Product name
7-Hydroxy-1,3-benzodioxole-5-carboxylicAcidMethylEster
Packaging
1g
Price
$1100
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
58658
Product name
7-Hydroxy-1,3-benzodioxole-5-carboxylicAcidMethylEster
Packaging
100mg
Price
$625
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
58658
Product name
7-Hydroxy-1,3-benzodioxole-5-carboxylicAcidMethylEster
Packaging
1g
Price
$2000
Updated
2021/12/16
Chemenu
Product number
CM130721
Product name
methyl7-hydroxybenzo[d][1,3]dioxole-5-carboxylate
Purity
95%
Packaging
5g
Price
$1047
Updated
2021/12/16
Alichem
Product number
116119018
Product name
Methyl7-hydroxybenzo[d][1,3]dioxole-5-carboxylate
Packaging
5g
Price
$1097.6
Updated
2021/12/16
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1,3-Benzodioxole-5-carboxylic acid, 7-hydroxy-, methyl ester Chemical Properties,Usage,Production

Uses

7-Hydroxy-1,3-benzodioxole-5-carboxylic Acid Methyl Ester is an intermediate in the synthesis of natural dihydrostilbenes with significant cytotoxicity toward human cancer cell lines.

Synthesis

75-11-6

99-24-1

116119-01-8

Potassium carbonate (4.002 g, 29 mmol) and methyl gallate (6 g, 29.7 mmol) were dissolved in anhydrous dichloromethane followed by the addition of diiodomethane (2.8 mL, 34.8 mmol) under nitrogen atmosphere and at room temperature. The reaction mixture was stirred at 0 °C for 5 h and then warmed up to 120 °C to continue the reaction. Upon completion of the reaction, the mixture was poured into cooled water (500 mL) and extracted with ethyl acetate. The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by column chromatography (eluent: 15% ethyl acetate/hexane) to afford the target product methyl 7-hydroxybenzo[d][1,3]meso-dioxole-5-carboxylate (3.6 g, 58% yield) as a white amorphous powder.

References

[1] Tetrahedron Asymmetry, 2009, vol. 20, # 4, p. 440 - 448
[2] Synlett, 2018, vol. 29, # 7, p. 908 - 911
[3] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 7, p. 2297 - 2298
[4] Liebigs Annalen der Chemie, 1994, # 4, p. 361 - 364
[5] Synthesis, 2009, # 20, p. 3383 - 3390

1,3-Benzodioxole-5-carboxylic acid, 7-hydroxy-, methyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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1,3-Benzodioxole-5-carboxylic acid, 7-hydroxy-, methyl ester Suppliers

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116119-01-8, 1,3-Benzodioxole-5-carboxylic acid, 7-hydroxy-, methyl esterRelated Search:


  • 1,3-Benzodioxole-5-carboxylic acid, 7-hydroxy-, methyl ester
  • Methyl 7-hydroxybenzo[d][1,3]dioxole-5-carboxylate
  • Methyl 3,4-Methylenedioxy-5-hydroxybenzoate
  • 7-Hydroxy-1,3-benzodioxole-5-carboxylic Acid Methyl Ester
  • methyl 7-hydroxy-1,3-benzodioxole-5-carboxylate
  • methyl 7-hydroxy-2H-1,3-benzodioxole-5-carboxylate
  • 7-Hydroxy-1,3-benzodioxole-5-carboxylic Acid Methyl Ester, CAS 116119-01-8
  • 116119-01-8