6-(tert-butoxycarbonyl)-6-azaspiro[2.5]octane-1-carboxylic acid
Application- Product Name
- 6-(tert-butoxycarbonyl)-6-azaspiro[2.5]octane-1-carboxylic acid
- CAS No.
- 871727-05-8
- Chemical Name
- 6-(tert-butoxycarbonyl)-6-azaspiro[2.5]octane-1-carboxylic acid
- Synonyms
- 6-azaspiro[2.5]octane-1-carboxylic acid;6-Boc-6-azaspiro[2.5]octane-1-carboxylic Acid;6-Azaspiro[2.5]octane-1-carboxylic acid, N-BOC protected;6-(tert-butoxycarbonyl)-6-azaspiro[2.5]octane-1-carboxylic acid;6-(tert-butoxycarbonyl)-6-azaspiro[2.5]octane-1,6-dicarboxylic acid;6-Azaspiro[2.5]octane-1,6-dicarboxylic acid, 6-(1,1-dimethylethyl) ester;3. 6-[(tert-Butoxy)carbonyl]-6-a7.aspiro[2 5]octane- l -carboxyl ic acid;6-(tert-butoxycarbonyl)-6-azaspiro 2.5 octane-1-carboxylic acid(SALTDATA;6-[(2-methylpropan-2-yl)oxycarbonyl]-6-azaspiro[2.5]octane-2-carboxylic acid;6-(tert-butoxycarbonyl)-6-azaspiro[2.5]octane-1-carboxylic acid(SALTDATA: FREE)
- CBNumber
- CB62527118
- Molecular Formula
- C13H21NO4
- Formula Weight
- 255.31
- MOL File
- 871727-05-8.mol
6-(tert-butoxycarbonyl)-6-azaspiro[2.5]octane-1-carboxylic acid Property
- Boiling point:
- 392.1±35.0 °C(Predicted)
- Density
- 1.20±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 4.71±0.20(Predicted)
- form
- solid
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- CBR01577
- Product name
- 6-(tert-Butoxycarbonyl)-6-azaspiro[2.5]octane-1-carboxylic acid
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $259
- Updated
- 2025/07/31
- Product number
- 055455
- Product name
- 6-(tert-Butoxycarbonyl)-6-azaspiro[2.5]octane-1-carboxylic acid
- Purity
- >95%
- Packaging
- 1g
- Price
- $300
- Updated
- 2021/12/16
- Product number
- 1169AF
- Product name
- 6-(tert-Butoxycarbonyl)-6-azaspiro[2.5]octane-1-carboxylic acid
- Packaging
- 1g
- Price
- $154
- Updated
- 2021/12/16
- Product number
- CS-W003745
- Product name
- 6-(tert-Butoxycarbonyl)-6-azaspiro[2.5]octane-1-carboxylic acid
- Purity
- ≥97.0%
- Packaging
- 5g
- Price
- $240
- Updated
- 2021/12/16
- Product number
- CS-W003745
- Product name
- 6-(tert-Butoxycarbonyl)-6-azaspiro[2.5]octane-1-carboxylic acid
- Purity
- ≥97.0%
- Packaging
- 10g
- Price
- $435
- Updated
- 2021/12/16
6-(tert-butoxycarbonyl)-6-azaspiro[2.5]octane-1-carboxylic acid Chemical Properties,Usage,Production
Application
6-BOC-6-azaspiro[2.5]octane-1-carboxylic acid is an important pharmaceutical intermediate and a key raw material for the synthesis of many drugs and excipients. It is used in the preparation of tyrosine kinases and some protein kinase inhibitors.
Synthesis
1242268-17-2
871727-05-8
Step 3: 6-tert-butyl 1-ethyl 6-azaspiro[2.5]octane-1,6-dicarboxylate (500 mg, 1.76 mmol) was dissolved in ethanol (8 mL) and a solution of sodium hydroxide (212 mg, 5.3 mmol) in water (4 mL) was added. The reaction mixture was stirred at 15°C for 12 hours. After completion of the reaction, the solvent was removed by evaporation under reduced pressure. The residue was dissolved in water and slowly acidified with dilute hydrochloric acid (0.5 M) under cooling in an ice bath to pH ~ 4. The aqueous phase was extracted with ethyl acetate (10 mL x 3). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 6-(tert-butoxycarbonyl)-6-azaspiro[2.5]octane-1-carboxylic acid (390 mg, 83% yield) as a white solid.1H NMR (400 MHz, CDCl3): δ 3.52-3.42 (m, 3H), 3.38-3.35 (m, 1H), 1.75- 1.72 (m, 2H), 1.58-1.56 (m, 1H), 1.46-1.43 (m, 11H), 1.23-1.21 (m, 1H), 1.02-1.01 (m, 1H).
References
[1] Patent: WO2015/949, 2015, A1. Location in patent: Page/Page column 117-118
[2] Patent: WO2013/127269, 2013, A1. Location in patent: Page/Page column 189; 190
6-(tert-butoxycarbonyl)-6-azaspiro[2.5]octane-1-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
6-(tert-butoxycarbonyl)-6-azaspiro[2.5]octane-1-carboxylic acid Suppliers
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- Fax
- E-Mail Inquiry
- info@syntechem.com
- Country
- China
- ProdList
- 12984
- Advantage
- 57
- Tel
- 025-85205967 13951876367
- Fax
- 025-85205967
- shengsaichem@163.com
- Country
- China
- ProdList
- 818
- Advantage
- 58
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 0513-85921823 18662920231
- Fax
- 86-513-85012876
- sales@ntminyanmedical.com
- Country
- China
- ProdList
- 4107
- Advantage
- 58
- Tel
- 19916721580
- Fax
- QQ：3154870176
- mafarm@126.com
- Country
- China
- ProdList
- 4542
- Advantage
- 58
- Tel
- +86 (21) 61124340
- Fax
- +86 (21) 6129-4103
- Country
- China
- ProdList
- 9756
- Advantage
- 58
- Tel
- 021-60455363 18019463053
- Fax
- 50966098
- sales@coolpharm.com
- Country
- China
- ProdList
- 12346
- Advantage
- 58
- Tel
- +1(858) 699-3322
- Fax
- +1(858) 876-1948
- marketing@accelachem.com
- Country
- United States
- ProdList
- 6024
- Advantage
- 65
- Tel
- 021-64340559 13651849907;
- Fax
- 021- 64345308
- xinyu_shi@jwypharmlab.com.cn
- Country
- China
- ProdList
- 12000
- Advantage
- 58
View Lastest Price from 6-(tert-butoxycarbonyl)-6-azaspiro[2.5]octane-1-carboxylic acid manufacturers
- Product
- 6-(tert-butoxycarbonyl)-6-azaspiro[2.5]octane-1-carboxylic acid(SALTDATA: FREE) 871727-05-8
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 95%-99%
- Supply Ability
- 1000kg
- Release date
- 2018-12-25