2-(6-methylpyridin-3-yl)acetic acid
- Product Name
- 2-(6-methylpyridin-3-yl)acetic acid
- CAS No.
- 19733-96-1
- Chemical Name
- 2-(6-methylpyridin-3-yl)acetic acid
- Synonyms
- 2-(6-Methylpyridin-3-yl);6-Methyl-3-pyridineacetic acid;3-Pyridineacetic acid, 6-methyl-;2-(6-Methyl-3-pyridyl)acetic Acid;2-(6-methylpyridin-3-yl)acetic acid
- CBNumber
- CB62534862
- Molecular Formula
- C8H9NO2
- Formula Weight
- 151.16
- MOL File
- 19733-96-1.mol
2-(6-methylpyridin-3-yl)acetic acid Property
- Melting point:
- 73-74 °C
- Boiling point:
- 125-127 °C
- Density
- 1.196±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 3.68±0.10(Predicted)
- Appearance
- Off-white to light yellow Solid
- InChI
- InChI=1S/C8H9NO2/c1-6-2-3-7(5-9-6)4-8(10)11/h2-3,5H,4H2,1H3,(H,10,11)
- InChIKey
- DWTRPWLHNATUPX-UHFFFAOYSA-N
- SMILES
- C1=NC(C)=CC=C1CC(O)=O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M341175
- Product name
- 2-(6-Methylpyridin-3-yl)aceticacid
- Packaging
- 50mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- OR952061
- Product name
- 2-(6-Methylpyridin-3-yl)aceticacid
- Purity
- 95%
- Packaging
- 250mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- 082453
- Product name
- (6-Methylpyridin-3-yl)acetic acid
- Purity
- 97%
- Packaging
- 500mg
- Price
- $181
- Updated
- 2021/12/16
- Product number
- 082453
- Product name
- (6-Methylpyridin-3-yl)acetic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $278
- Updated
- 2021/12/16
- Product number
- OR952061
- Product name
- 2-(6-Methylpyridin-3-yl)aceticacid
- Purity
- 95%
- Packaging
- 1g
- Price
- $345
- Updated
- 2021/12/16
2-(6-methylpyridin-3-yl)acetic acid Chemical Properties,Usage,Production
Synthesis
19733-95-0
19733-96-1
Example 3: Preparation of 2-methyl-5-pyridylacetic acid; 2-(6-methylpyridin-3-yl)morpholinoethylthione (25 g) was dissolved in 200 mL of ethanol, followed by addition of a 60% aqueous NaOH solution (21 g NaOH dissolved in 25 mL of water). The reaction mixture was heated to 80 °C and refluxed for 17 hours. After completion of the reaction, it was cooled to room temperature and the solvent was removed by rotary evaporation. A small amount of water was added to dissolve the residue and the pH was adjusted with concentrated hydrochloric acid to 2. The insoluble material was removed by filtration and the filtrate was extracted twice with ether, the ether layers were combined and washed once with distilled water. The aqueous layer was retained and set aside. The water in the solvent was removed by rotary evaporation and the product was dried in a vacuum drying oven for 24 h to give 2-methyl-5-pyridylacetic acid (11 g) in about 70% yield. The product was characterized by 1H-NMR (400 MHz, DMSO-d6): δ 2.43 (3H, s, CH3); 3.57 (2H, s, CH2); 7.17-7.19 (1H, d, ArH); 7.53-7.56 (1H, dd, ArH); 8.30-8.31 (1H, d, ArH); 12.42 (1H, s , COOH).
References
[1] Patent: EP2417973, 2012, A1. Location in patent: Page/Page column 6-8; 16
[2] Patent: US2012/122914, 2012, A1. Location in patent: Page/Page column 5
[3] Patent: WO2010/67085, 2010, A2. Location in patent: Page/Page column 60-61
2-(6-methylpyridin-3-yl)acetic acid Preparation Products And Raw materials
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