ChemicalBook > CAS DataBase List > 4-(5-Amino-2-pyridin-3-yl-thiazolo[5,4-d]pyrimidin-7-yl)-piperazine-1-carboxylic acid p-tolylamide

4-(5-Amino-2-pyridin-3-yl-thiazolo[5,4-d]pyrimidin-7-yl)-piperazine-1-carboxylic acid p-tolylamide

Product Name
4-(5-Amino-2-pyridin-3-yl-thiazolo[5,4-d]pyrimidin-7-yl)-piperazine-1-carboxylic acid p-tolylamide
CAS No.
1245319-54-3
Chemical Name
4-(5-Amino-2-pyridin-3-yl-thiazolo[5,4-d]pyrimidin-7-yl)-piperazine-1-carboxylic acid p-tolylamide
Synonyms
PI4KIII β inhibitor 3;PI4KIII beta inhibitor 3;PI-4KIII beta inhibitor 3,PI4KIII beta inhibitor 3;4-(5-aMino-2-(pyridin-3-yl)thiazolo[5,4-d]pyriMidin-7-yl)-N-p-tolylpiperazine-1-carboxaMide;4-(5-Amino-2-pyridin-3-yl-thiazolo[5,4-d]pyrimidin-7-yl)-piperazine-1-carboxylic acid p-tolylamide;1-Piperazinecarboxamide, 4-[5-amino-2-(3-pyridinyl)thiazolo[5,4-d]pyrimidin-7-yl]-N-(4-methylphenyl)-
CBNumber
CB62535324
Molecular Formula
C22H22N8OS
Formula Weight
446.53
MOL File
1245319-54-3.mol
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4-(5-Amino-2-pyridin-3-yl-thiazolo[5,4-d]pyrimidin-7-yl)-piperazine-1-carboxylic acid p-tolylamide Property

Density 
1.432±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Powder
pka
13.95±0.70(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-1460
Product name
PI4KIIIbetainhibitor3
Purity
99.44%
Packaging
2mg
Price
$264
Updated
2021/12/16
ApexBio Technology
Product number
A3122
Product name
PI4KIIIbetainhibitor3
Packaging
2mg
Price
$391
Updated
2021/12/16
ChemScene
Product number
CS-1460
Product name
PI4KIIIbetainhibitor3
Purity
99.44%
Packaging
5mg
Price
$420
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0389704
Product name
4-(5-AMINO-2-(PYRIDIN-3-YL)THIAZOLO[5,4-D]PYRIMIDIN-7-YL)-N-(PARA-TOLYL)PIPERAZINE-1-CARBOXAMIDE
Purity
95.00%
Packaging
5MG
Price
$505.29
Updated
2021/12/16
ChemScene
Product number
CS-1460
Product name
PI4KIIIbetainhibitor3
Purity
99.44%
Packaging
10mg
Price
$660
Updated
2021/12/16
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4-(5-Amino-2-pyridin-3-yl-thiazolo[5,4-d]pyrimidin-7-yl)-piperazine-1-carboxylic acid p-tolylamide Chemical Properties,Usage,Production

Uses

PI4KIII beta inhibitor 3 is a novel and high effective PI4KIIIβ inhibitor with IC50 of 5.7 nM.

in vivo

PI4KIII beta inhibitor 3 (40 mg/kg per day, n=12) is able to delay the onset of arthritic symptoms and also to decrease symptom severity in a preventive model of arthritis compared to a vehicle control (MC 1%, n=12). PI4KIII beta inhibitor 3 reduces the anti-CII IgG titre and histological scores in the collagen-induced arthritis mouse model. Oral administration of PI4KIII beta inhibitor 3 results in prolonged graft survival in 3 out of 6 grafts in each group at day 30. Several grafts continued beating after withdrawal of the treatment (up to 60 days), indicating the induction of a certain type of graft tolerance. To evaluate the operational tolerance phenotype, animals with functional graft at day 60 are challenged with a second graft from the same donor strain or from a third party. No treatment is applied. The second grafts from the third party are rejected at day 8 (n=2) whereas second grafts from the same donor strain are functional for more than 90 days (n=2)[1].

IC 50

PI4KIIIβ: 5.7 nM (IC50)

References

[1] Jean Herman, et al. Autoimmune and inflammatory disorder therapy. From PCT Int. Appl. (2013), WO 2013034738 A1

4-(5-Amino-2-pyridin-3-yl-thiazolo[5,4-d]pyrimidin-7-yl)-piperazine-1-carboxylic acid p-tolylamide Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(5-Amino-2-pyridin-3-yl-thiazolo[5,4-d]pyrimidin-7-yl)-piperazine-1-carboxylic acid p-tolylamide Suppliers

China 30 United States 8 Global 38
China Langchem Inc.
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0086-21-58956006
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Haoyuan Chemexpress Co., Ltd.
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021-58950125
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(86) 21-58955996
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Cantotech Chemicals, Ltd.
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86-0755-86635001
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86-0755-22642228
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Sichuan Wei Keqi Biological Technology Co., Ltd.
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028-81700200 18116577057
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LETOPHARM LIMITED
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SPIRO PHARMA
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Codow Chemical Co.,Ltd.
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18620099427
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+86-20-62619665
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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021-65675885
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Guangzhou QiYun Biotechnology Co., Ltd.
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020-61288194 61288195
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020-61288700
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505721671@qq.com
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Chengdu Huachun Technology Co., Ltd
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400-1166-196 15982826727
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1245319-54-3, 4-(5-Amino-2-pyridin-3-yl-thiazolo[5,4-d]pyrimidin-7-yl)-piperazine-1-carboxylic acid p-tolylamideRelated Search:


  • PI4KIII β inhibitor 3
  • 4-(5-Amino-2-pyridin-3-yl-thiazolo[5,4-d]pyrimidin-7-yl)-piperazine-1-carboxylic acid p-tolylamide
  • 4-(5-aMino-2-(pyridin-3-yl)thiazolo[5,4-d]pyriMidin-7-yl)-N-p-tolylpiperazine-1-carboxaMide
  • PI4KIII beta inhibitor 3
  • 1-Piperazinecarboxamide, 4-[5-amino-2-(3-pyridinyl)thiazolo[5,4-d]pyrimidin-7-yl]-N-(4-methylphenyl)-
  • PI-4KIII beta inhibitor 3,PI4KIII beta inhibitor 3
  • 1245319-54-3
  • C22H22N8OS
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  • Akt
  • mTOR
  • PI3K