PRX-08066

Product Name: PRX-08066
CAS No.: 866206-54-4
Chemical Name: PRX-08066
Synonyms: PRX-8066;PRX-08066;PRX08066;PRX 08066;PRX-08066, 10 mM in DMSO;5-[[4-[(6-Chlorothieno[2,3-d]pyrimidin-4-yl)amino]-1-piperidinyl]methyl]-2-fluorobenzonitrile;5-((4-((6-Chlorothieno[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)methyl)-2-fluorobenzonitrile;Benzonitrile, 5-[[4-[(6-chlorothieno[2,3-d]pyrimidin-4-yl)amino]-1-piperidinyl]methyl]-2-fluoro-;5-HT Receptor,5-hydroxytryptamine Receptor,Serotonin Receptor,PRX-08066,PRX 08066,PRX08066,inhibit,Inhibitor
CBNumber: CB62538815
Molecular Formula: C19H17ClFN5S
Formula Weight: 401.89
MOL File: 866206-54-4.mol

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PRX-08066 Property

Density: 1.44
storage temp.: Store at -20°C
solubility: ≥20.1 mg/mL in DMSO with ultrasonic; insoluble in H2O; ≥2.85 mg/mL in EtOH with gentle warming
form: solid
color: White to off-white
InChI: InChI=1S/C19H17ClFN5S/c20-17-8-15-18(23-11-24-19(15)27-17)25-14-3-5-26(6-4-14)10-12-1-2-16(21)13(7-12)9-22/h1-2,7-8,11,14H,3-6,10H2,(H,23,24,25)
InChIKey: IENZFHBNCRQMNP-UHFFFAOYSA-N
SMILES: C(#N)C1=CC(CN2CCC(NC3N=CN=C4SC(Cl)=CC4=3)CC2)=CC=C1F

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 31477
Product name: PRX-08066
Purity: ≥95%
Packaging: 1mg
Price: $81
Updated: 2026/04/30

Cayman Chemical

Product number: 31477
Product name: PRX-08066
Purity: ≥95%
Packaging: 5mg
Price: $317
Updated: 2026/04/30

Cayman Chemical

Product number: 31477
Product name: PRX-08066
Purity: ≥95%
Packaging: 10mg
Price: $475
Updated: 2026/04/30

Usbiological

Product number: 474171
Product name: PRX 08066
Packaging: 100mg
Price: $1848
Updated: 2021/12/16

ChemScene

Product number: CS-0991
Product name: PRX-08066
Purity: 97.04%
Packaging: 10mg
Price: $280
Updated: 2021/12/16

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PRX-08066 Chemical Properties,Usage,Production

Uses

PRX 08066 is a class 2 receptor antagonist which may be used in the treatment of pulmonary diseases.

Biological Activity

prx-08066 is a selective antagonist of 5-hydroxytryptamine receptor 2b (5-ht2br) with ki value of 3.4nm [1].prx-08066 is found to causes selective vasodilation of pulmonary arteries and is developed to treat for pulmonary arterial hypertension (pah). in the in vitro studies, prx-08066 shows effects on the vascular muscularization induced by 5-ht. it inhibits 5-ht induced mitogen-activated protein kinase activation with ic50 value of 12nm. in addition, it significantly reduces thymidine incorporation in cho cells expressing human 5-ht2br with ic50 value of 3nm. in both mice and rat models, prx-08066 reverses the hypoxia-dependent increase in right ventricular systolic pressure. besides that, prx-08066 is also found to have anti-proliferative and anti-fibrotic effects. it inhibits the secretion of 5-ht, the phosphorylation of erk1/2 and synthesis of profibrotic growth factor. moreover, prx-08066 inhibits the proliferation of the small intestinal neuroendocrine tumor cell line krj-i with ic50 value of 4.6nm [1, 2].

IC 50

5-HT_2B Receptor: 3.4 nM (IC₅₀)

References

[1] porvasnik s l, germain s, embury j, et al. prx-08066, a novel 5-hydroxytryptamine receptor 2b antagonist, reduces monocrotaline-induced pulmonary arterial hypertension and right ventricular hypertrophy in rats. journal of pharmacology and experimental therapeutics, 2010, 334(2): 364-372.
[2] svejda b, kidd m, giovinazzo f, et al. the 5-ht2b receptor plays a key regulatory role in both neuroendocrine tumor cell proliferation and the modulation of the fibroblast component of the neoplastic microenvironment. cancer, 2010, 116(12): 2902-2912.

PRX-08066 Preparation Products And Raw materials

Raw materials

Preparation Products

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PRX-08066 Suppliers

China 62 India 1 United Kingdom 1 United States 10 Global 74

MQ (shanghai) Pharmaceuticals Co., Ltd.

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866206-54-4, PRX-08066Related Search:

PRX-08066

PRX-8066

5-[[4-[(6-Chlorothieno[2,3-d]pyrimidin-4-yl)amino]-1-piperidinyl]methyl]-2-fluorobenzonitrile

PRX08066;PRX 08066

Benzonitrile, 5-[[4-[(6-chlorothieno[2,3-d]pyrimidin-4-yl)amino]-1-piperidinyl]methyl]-2-fluoro-

5-HT Receptor,5-hydroxytryptamine Receptor,Serotonin Receptor,PRX-08066,PRX 08066,PRX08066,inhibit,Inhibitor

5-((4-((6-Chlorothieno[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)methyl)-2-fluorobenzonitrile

PRX-08066, 10 mM in DMSO

866206-54-4

C19H17ClFN5S