ChemicalBook > CAS DataBase List > HA 130

HA 130

Product Name
HA 130
CAS No.
1229652-21-4
Chemical Name
HA 130
Synonyms
HA 150;HA 130;CS-1606;HA130 ，S0424;HA130 (HA-130);HA130;HA-130;HA 130;HA130, 10 mM in DMSO;HA130 (Autotaxin Inhibitor);inhibit,HA 130,HA130,Phosphodiesterase (PDE),Inhibitor,HA-130;(3-((4-((3-(4-Fluorobenzyl)-2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)methyl)phenyl)boronic acid
CBNumber
CB62546788
Molecular Formula
C24H19BFNO5S
Formula Weight
463.29
MOL File
1229652-21-4.mol
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HA 130 Property

storage temp. 
Store at -20°C
solubility 
DMF:10.0(Max Conc. mg/mL);21.58(Max Conc. mM)
DMSO:30.11(Max Conc. mg/mL);64.99(Max Conc. mM)
Ethanol:0.5(Max Conc. mg/mL);1.08(Max Conc. mM)
form 
Powder
color 
Light yellow to yellow
InChI
InChI=1S/C24H19BFNO5S/c26-20-8-4-17(5-9-20)14-27-23(28)22(33-24(27)29)13-16-6-10-21(11-7-16)32-15-18-2-1-3-19(12-18)25(30)31/h1-13,30-31H,14-15H2
InChIKey
VTNKMYWFWQTEHE-UHFFFAOYSA-N
SMILES
B(C1=CC=CC(COC2=CC=C(C=C3SC(=O)N(CC4=CC=C(F)C=C4)C3=O)C=C2)=C1)(O)O
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10498
Product name
HA-130
Purity
≥98%
Packaging
5mg
Price
$72
Updated
2024/03/01
Cayman Chemical
Product number
10498
Product name
HA-130
Purity
≥98%
Packaging
10mg
Price
$129
Updated
2024/03/01
Cayman Chemical
Product number
10498
Product name
HA-130
Purity
≥98%
Packaging
25mg
Price
$178
Updated
2024/03/01
Tocris
Product number
4196
Product name
HA130
Purity
≥98%(HPLC)
Packaging
10
Price
$225
Updated
2021/12/16
Tocris
Product number
4196
Product name
HA130
Purity
≥98%(HPLC)
Packaging
50
Price
$927
Updated
2021/12/16
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HA 130 Chemical Properties,Usage,Production

Uses

HA 150 is a selective boronic acid-based inhibitor of autotaxin. Studies show that adminstration of HA 150 in mice results in rapid decrease of the lipid mediator lysophosphatidic acid (LPA) in the circulation. These findings suggest that HA 150 may provide useful therapeutic strategy in treating disorders associated with vascular development, inflammation, fibrotic disease, and tumor progression.

Uses

HA130 is a selective boronic acid-based inhibitor of autotaxin. Studies show that adminstration of HA130 in mice results in rapid decrease of the lipid mediator lysophosphatidic acid (LPA) in the circulation. These findings suggest that HA 150 may provide useful therapeutic strategy in treating disorders associated with vascular development, inflammation, fibrotic disease, and tumor progression.

in vivo

HA130 slows T cell migration across lymph node HEVs. HA130 decreases the "outside HEVs/inside HEVs" ratio by 3-4-fold compared to vehicle-treated animals vehicle[1].
The s.c. administration of HA130 induces marked lymphocyte accumulation within the endothelial cell (EC) and sub-EC layers of HEVs in draining lymph nodes (LNs)[2].

IC 50

Autotaxin: 28 nM (IC50)

storage

Store at -20°C

HA 130 Preparation Products And Raw materials

Raw materials

Preparation Products

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HA 130 Suppliers

Canada 1 China 73 India 1 United Kingdom 1 United States 15 Global 91
Weifang Xiaoyuan Chemical Industry & Trade Co. , Ltd.
Tel
15621199386
Email
qdyyhx@163.com
Country
China
ProdList
33
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6003
Advantage
61
VDM Biochemicals
Tel
0330-2528181
Fax
0330-2528171
Email
sales@vdmbio.com
Country
United States
ProdList
510
Advantage
64
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
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58
Shanghai TaoSu Biochemical Technology Co., Ltd.
Tel
021-33632979
Fax
021-34692979
Email
info@tsbiochem.com
Country
China
ProdList
8065
Advantage
58
Shanghai YuanQi Biotechnology Co., Ltd.
Tel
+86-2332782371 +86-18120098618
Email
sales@adobechem.com
Country
China
ProdList
1250
Advantage
50

1229652-21-4, HA 130Related Search:


  • B-[3-[[4-[[3-[(4-Fluorophenyl)Methyl]-2,4-dioxo-5-thiazolidinylidene]Methyl]phenoxy]Methyl]phenyl]boronic Acid
  • HA130 (Autotaxin Inhibitor)
  • HA 130
  • HA 150
  • HA130 (HA-130)
  • (Z)-3-((4-((3-(4-fluorobenzyl)-2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)methyl)phenylboronic acid
  • CS-1606
  • HA130;HA-130;HA 130
  • Boronic acid, B-[3-[[4-[[3-[(4-fluorophenyl)methyl]-2,4-dioxo-5-thiazolidinylidene]methyl]phenoxy]methyl]phenyl]-
  • inhibit,HA 130,HA130,Phosphodiesterase (PDE),Inhibitor,HA-130
  • [4-[[4-[(Z)-[3-[(4-fluorophenyl)methyl]-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl]phenoxy]methyl]phenyl]boronic acid
  • (3-((4-((3-(4-Fluorobenzyl)-2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)methyl)phenyl)boronic acid
  • HA130, 10 mM in DMSO
  • HA130 ，S0424
  • 1229652-21-4
  • Aromatics, Boron Derivatives, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals
  • Aromatics
  • Boron Derivatives
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Selective autotaxin inhibitor.