3-Methylpiperidine-2,6-dione
- Product Name
- 3-Methylpiperidine-2,6-dione
- CAS No.
- 29553-51-3
- Chemical Name
- 3-Methylpiperidine-2,6-dione
- Synonyms
- 3-Methyl-2,6-piperidinedione;3-Methylpiperidine-2,6-dione;2,6-Dioxo-3-methyl-piperazine;2,6-Piperidinedione, 3-methyl-
- CBNumber
- CB62549486
- Molecular Formula
- C6H9NO2
- Formula Weight
- 127.14
- MOL File
- 29553-51-3.mol
3-Methylpiperidine-2,6-dione Property
- Melting point:
- 101-102 °C(Solv: ethanol (64-17-5); ethyl ether (60-29-7))
- Boiling point:
- 277.9±9.0 °C(Predicted)
- Density
- 1.101±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 11.79±0.40(Predicted)
- Appearance
- White to off-white Solid
N-Bromosuccinimide Price
- Product number
- CS-0061420
- Product name
- 3-Methylpiperidine-2,6-dione
- Packaging
- 100mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- CS-0061420
- Product name
- 3-Methylpiperidine-2,6-dione
- Packaging
- 250mg
- Price
- $208
- Updated
- 2021/12/16
- Product number
- CS-0061420
- Product name
- 3-Methylpiperidine-2,6-dione
- Packaging
- 1g
- Price
- $416
- Updated
- 2021/12/16
- Product number
- CHM0389352
- Product name
- 3-METHYLPIPERIDINE-2,6-DIONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.43
- Updated
- 2021/12/16
- Product number
- CS-0061420
- Product name
- 3-Methylpiperidine-2,6-dione
- Packaging
- 5g
- Price
- $1248
- Updated
- 2021/12/16
3-Methylpiperidine-2,6-dione Chemical Properties,Usage,Production
Synthesis
18069-17-5
29553-51-3
Preparative Example 23: Synthesis of 3-methylpiperidine-2,6-dione Acetic anhydride (appropriate amount) was added to commercially available 2-methylglutaric acid (1 g, 6.8 mmol) at room temperature, and the mixture was refluxed and stirred at 60°C for 8 hours. After confirming the completion of the reaction by thin layer chromatography (TLC), the remaining acetic anhydride was removed under reduced pressure. The concentrated compound was dissolved in tetrahydrofuran (THF) and aqueous ammonia solution (1.7 mL, 14.6 mmol) was slowly added at 0 °C, followed by stirring for 8 h at room temperature. Upon completion of the reaction, the remaining ammonia solution was removed under reduced pressure, acetic anhydride was added, and then refluxed at 60 °C for 8 hours. The residual acetic anhydride was removed under reduced pressure. The concentrate was purified by column chromatography (eluent: ethyl acetate/hexane=1:1) to afford 682 mg (yield: 78%) of 3-methylpiperidine-2,6-dione. 1H NMR (400 MHz, MeOH-d4) δ 1.24-1.28 (m, 3H), 1.71-1.77 (m, 1H), 2.04-2.08 (m, 1H), 2.57-2.65 (m, 3H); MS (m/z) 128 (M+1).
References
[1] Patent: WO2009/82134, 2009, A2. Location in patent: Page/Page column 84-85
[2] Journal of the American Chemical Society, 1943, vol. 65, p. 270
[3] Bulletin de l'Academie Polonaise des Sciences, Serie des Sciences Chimiques, 1981, vol. 29, # 1-2, p. 11 - 16
[4] Journal of the American Chemical Society, 1982, vol. 104, # 25, p. 7257 - 7267
3-Methylpiperidine-2,6-dione Preparation Products And Raw materials
Raw materials
Preparation Products
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