Methyl2-aMino-5-nitronicotinate
- Product Name
- Methyl2-aMino-5-nitronicotinate
- CAS No.
- 88312-64-5
- Chemical Name
- Methyl2-aMino-5-nitronicotinate
- Synonyms
- Methyl2-aMino-5-nitronicotinate;2-aMino-5-nitronicotinic acid Methyl ester;2-aMino-3-(Methoxycarbonyl)-5-nitropyridine;Methyl 2-aMino-5-nitropyridine-3-carboxylate;Methyl2-aMino-5-nitronicotinate ISO 9001：2015 REACH;3-Pyridinecarboxylic acid, 2-amino-5-nitro-, methyl ester
- CBNumber
- CB62550628
- Molecular Formula
- C7H7N3O4
- Formula Weight
- 197.15
- MOL File
- 88312-64-5.mol
Methyl2-aMino-5-nitronicotinate Property
- Melting point:
- 199-200 °C
- Boiling point:
- 372.3±37.0 °C(Predicted)
- Density
- 1.463±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 0.62±0.49(Predicted)
- Appearance
- Off-white to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- M331738
- Product name
- Methyl2-Amino-5-nitronicotinate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- W9053
- Product name
- Methyl2-amino-5-nitronicotinate
- Packaging
- 100mg
- Price
- $74
- Updated
- 2021/12/16
- Product number
- W9053
- Product name
- Methyl2-amino-5-nitronicotinate
- Packaging
- 1g
- Price
- $111
- Updated
- 2021/12/16
- Product number
- CHM0392923
- Product name
- METHYL-2-AMINO-5-NITRONICOTINATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.67
- Updated
- 2021/12/16
- Product number
- W9053
- Product name
- Methyl2-amino-5-nitronicotinate
- Packaging
- 25g
- Price
- $621
- Updated
- 2021/12/16
Methyl2-aMino-5-nitronicotinate Chemical Properties,Usage,Production
Uses
Methyl 2-amino-5-nitronicotinate is a useful chemical for the synthesis of polyfunctionalized benzo[d]thiazole and its aza analog thiazolo[5,4-b]pyridine.
Synthesis
14667-47-1
88312-64-5
Methyl 2-aminopyridine-3-carboxylate (10.0 g, 72.4 mmol) was added slowly dropwise from concentrated nitric acid (65%, 3.2 mmol, 76 mmol, 1.05 eq.) to a stirred suspension of concentrated sulfuric acid (96%, 90.5 mL, 1.69 mol, 23.3 eq.) at 0 °C. The reaction mixture was gradually brought to room temperature and stirred continuously for 2 hours. The resulting brown mixture was carefully poured into ice water and solid Na2CO3 was added by batchwise addition until complete neutralization (pH > 8). Subsequently, the aqueous layer was extracted three times with ethyl acetate (AcOEt). The combined organic layers were washed sequentially with saturated saline and deionized water and dried over anhydrous magnesium sulfate (MgSO4). Finally, the solvent was removed by vacuum evaporation to afford the target product 2-amino-3-carboxylic acid methyl ester-5-nitropyridine (11.7 g, 82% yield) as a colorless solid with a purity meeting the analytical requirements.
References
[1] Tetrahedron, 2014, vol. 70, # 35, p. 5541 - 5549
[2] Patent: WO2015/189595, 2015, A1. Location in patent: Page/Page column 48; 49
[3] Patent: EP1782811, 2007, A1. Location in patent: Page/Page column 42
[4] Patent: EP1669348, 2006, A1. Location in patent: Page/Page column 50
Methyl2-aMino-5-nitronicotinate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl2-aMino-5-nitronicotinate manufacturers
- Product
- Methyl 2-aMino-5-nitronicotinate 88312-64-5
- Price
- US $1.00-1.00/Kg/Drum
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 50tons
- Release date
- 2020-05-13
- Product
- Methyl2-aMino-5-nitronicotinate 88312-64-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-23