Fosravuconazole L-lysine ethanolate
- Product Name
- Fosravuconazole L-lysine ethanolate
- CAS No.
- 914361-45-8
- Chemical Name
- Fosravuconazole L-lysine ethanolate
- Synonyms
- E-1224 L-lysine ethanolate;BMS-379224 L-lysine ethanolate;Fosravuconazole L-lysine ethanolate;L-Lysine, coMpd. with 4-[2-[(1R,2R)-2-(2,4-difluorophenyl)-1-Methyl-2-[(phosphonooxy)Methoxy]-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]benzonitrile and ethanol (1:1:1) (9CI);(S)-2,6-Diaminohexanoic acid (((2R,3R)-3-(4-(4-cyanophenyl)thiazol-2-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-yl)oxy)methyl dihydrogen phosphate and ethanol salt;Fungal,onychomycosis,Fosravuconazole Llysine ethanolate,Parasite,parasitemia,inhibit,Fosravuconazole L lysine ethanolate,antifungal,Ravuconazole,Inhibitor,candidiasis,Fosravuconazole L-lysine
- CBNumber
- CB62563389
- Molecular Formula
- C31H40F2N7O8PS
- Formula Weight
- 739.73
- MOL File
- 914361-45-8.mol
Fosravuconazole L-lysine ethanolate Property
- storage temp.
- Store at -20°C
- solubility
- DMSO : 50 mg/mL (67.59 mM; Need ultrasonic)| (insoluble)
- form
- Solid
- color
- White to yellow
- Water Solubility
- Water : < 0.1 mg/mL (ultrasonic)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-0145609
- Product name
- Fosravuconazole(L-lysineethanolate)
- Purity
- 96.30%
- Packaging
- 5mg
- Price
- $300
- Updated
- 2021/12/16
- Product number
- CS-0145609
- Product name
- Fosravuconazole(L-lysineethanolate)
- Purity
- 96.30%
- Packaging
- 10mg
- Price
- $500
- Updated
- 2021/12/16
- Product number
- CS-0145609
- Product name
- Fosravuconazole(L-lysineethanolate)
- Purity
- 96.30%
- Packaging
- 25mg
- Price
- $950
- Updated
- 2021/12/16
- Product number
- CS-0145609
- Product name
- Fosravuconazole(L-lysineethanolate)
- Purity
- 96.30%
- Packaging
- 50mg
- Price
- $1550
- Updated
- 2021/12/16
- Product number
- CS-0145609
- Product name
- Fosravuconazole(L-lysineethanolate)
- Purity
- 96.30%
- Packaging
- 100mg
- Price
- $2350
- Updated
- 2021/12/16
Fosravuconazole L-lysine ethanolate Chemical Properties,Usage,Production
Uses
Fosravuconazole L-lysine ethanolate (BMS-379224 L-lysine ethanolate), a proagent of Ravuconazole, is an orally active broad spectrum antifungal agent. Fosravuconazole L-lysine ethanolate can be used for candidiasis, onychomycosis and parasitemia research[1][2][3].
Biological Activity
Fosravuconazole L-lysine ethanolate (BMS-379224 L-lysine ethanolate), a prodrug of Ravuconazole, is an orally active broad-spectrum antifungal agent. Fosravuconazole L-lysine ethanolate can be used in the study of candidiasis, onychomycosis and parasitic diseases.
in vitro
Fosravuconazole has potent in vitro antifungal activity against a wide range of fungal species, including Candida , Aspergillus , and Trichophyton species .
in vivo
Fosravuconazole (E-1224; 10-50 mg/kg; oral administration; daily; for 20 days) treatment suppresses the parasitemia and prevents death in mice infected with the T. cruzi Y strain.
| Animal Model: | Swiss female mice (20-24 g) inoculated with trypomastigotes (Y strain). |
| Dosage: | 10 mg/kg, 20 mg/kg, 30 mg/kg, 40 mg/kg , 50 mg/kg |
| Administration: | Oral administration; daily; for 20 days |
| Result: | Suppressed the parasitemia and prevented death. |
References
[1] Shinichi Watanabe, et al. Efficacy and safety of fosravuconazole L-lysine ethanolate, a novel oral triazole antifungal agent, for the treatment of onychomycosis: A multicenter, double-blind, randomized phase III study. J Dermatol. 2018 Oct;45(10):1151-1159. DOI:10.1111/1346-8138.14607
[2] Katsura Hata, et al. Development of E1224 by leveraging a strategic partnership for the medicines creation against neglected tropical diseases. Parasitol Int. 2020 Dec 25;81:102278. DOI:10.1016/j.parint.2020.102278
[3] Lívia de Figueiredo Diniz, et al. Outcome of E1224-Benznidazole Combination Treatment for Infection with a Multidrug-Resistant Trypanosoma cruzi Strain in Mice. Antimicrob Agents Chemother. 2018 May 25;62(6):e00401-18. DOI:10.1128/AAC.00401-18
Fosravuconazole L-lysine ethanolate Preparation Products And Raw materials
Raw materials
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