1H-Pyrrolo[2,3-b]pyridine, 5-bromo-1-methyl-
- Product Name
- 1H-Pyrrolo[2,3-b]pyridine, 5-bromo-1-methyl-
- CAS No.
- 183208-22-2
- Chemical Name
- 1H-Pyrrolo[2,3-b]pyridine, 5-bromo-1-methyl-
- Synonyms
- 5-BroMo-1-Methyl-7-azaind..;5-BroMo-1-Methyl-7-azaindole;5-BroMo-1-Methylpyrrolo[2,3-b]pyridine;5-broMo-1-Methyl-1H-pyrrolo[2,3-b]pyridine;1H-Pyrrolo[2,3-b]pyridine, 5-bromo-1-methyl-
- CBNumber
- CB62570321
- Molecular Formula
- C8H7BrN2
- Formula Weight
- 211.06
- MOL File
- 183208-22-2.mol
1H-Pyrrolo[2,3-b]pyridine, 5-bromo-1-methyl- Property
- Boiling point:
- 294.3±20.0 °C(Predicted)
- Density
- 1.60±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 3.11±0.30(Predicted)
- Appearance
- Light brown to brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B808133
- Product name
- 5-Bromo-1-methyl-1H-pyrrolo[2,3-b]pyridine
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 3H32-9-1Z
- Product name
- 5-Bromo-1-methyl-7-azaindole
- Packaging
- 250mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 3H32-9-1Z
- Product name
- 5-Bromo-1-methyl-7-azaindole
- Packaging
- 1g
- Price
- $180
- Updated
- 2021/12/16
- Product number
- 9594AA
- Product name
- 5-Bromo-1-methyl-7-azaindole
- Packaging
- 1g
- Price
- $211
- Updated
- 2021/12/16
- Product number
- 112974
- Product name
- 5-Bromo-1-methyl-7-azaindole
- Packaging
- 1g
- Price
- $227
- Updated
- 2021/12/16
1H-Pyrrolo[2,3-b]pyridine, 5-bromo-1-methyl- Chemical Properties,Usage,Production
Synthesis
183208-35-7
74-88-4
183208-22-2
Sodium hydride (NaH, 365 mg, 9.1 mmol) was slowly added to a solution of 5-bromo-7-azaindole (1.5 g, 7.6 mmol) in N,N-dimethylformamide (DMF, 10 mL) at 0 °C. The reaction mixture was stirred at room temperature for 1.5 hours. Subsequently, iodomethane (MeI, 1.4 g, 9.8 mmol) was added and stirring was continued overnight at room temperature. Upon completion of the reaction, the reaction was quenched with saturated aqueous sodium bicarbonate (NaHCO3) solution, followed by the addition of ammonium chloride (NH4Cl, 10 mL) solution. The mixture was separated between water (20 mL) and ethyl acetate (EA, 20 mL). The organic layer was washed sequentially with water (10 mL) and saturated brine (10 mL) and dried over anhydrous sodium sulfate (Na2SO4). The solvent was removed under reduced pressure to afford 5-bromo-1-methyl-1H-pyrrolo[2,3-b]pyridine (1.7 g, yield: quantitative) as light yellow crystals.' HNMR (300 MHz, CDCl3): δ= 8.34 (d, J = 2.1 Hz, 1H), 8.01 (d, J = 2.4 Hz, 1H), 7.18 (d, J = 3.6 Hz, 1H), 6.39 (d, J = 3.3 Hz, 1H), 3.86 (s, 3H).
References
[1] Patent: WO2016/123392, 2016, A2. Location in patent: Paragraph 00786
[2] Patent: US2017/8889, 2017, A1. Location in patent: Paragraph 0149; 0150
[3] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 17, p. 5734 - 5739
[4] Beilstein Journal of Organic Chemistry, 2016, vol. 12, p. 309 - 313
[5] Marine Drugs, 2015, vol. 13, # 1, p. 460 - 492
1H-Pyrrolo[2,3-b]pyridine, 5-bromo-1-methyl- Preparation Products And Raw materials
Raw materials
Preparation Products
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