MK-5108 (VX-689)

ChemicalBook > CAS DataBase List > MK-5108 (VX-689)

Product Name: MK-5108 (VX-689)
CAS No.: 1010085-13-8
Chemical Name: MK-5108 (VX-689)
Synonyms: MK-5108;VX-689;CS-545;MK-5198;MK-5108(VX-689);MK-5108 (VX-689) USP/EP/BP;MK-5108 VX-689 Aurora Kinase Inhibitor;MK 5108; VX-689; VX 689; MK5108; VX689;trans-4-(3-Chloro-2-fluorophenoxy)-1-[[6-(2-thiazolylamino)-2-pyridinyl]methyl]cyclohexanecarboxylic acid;4-(3-chloro-2-fluorophenoxy)-1-[[6-(1,3-thiazol-2-ylamino)pyridin-2-yl]methyl]cyclohexane-1-carboxylic acid
CBNumber: CB62570376
Molecular Formula: C22H21ClFN3O3S
Formula Weight: 461.94
MOL File: 1010085-13-8.mol

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MK-5108 (VX-689) Property

Boiling point:: 637.6±65.0 °C(Predicted)
Density: 1.429
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: ≥23.1 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form: solid
pka: 4.41±0.44(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19167
Product name: MK-5108
Purity: ≥95%
Packaging: 1mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 19167
Product name: MK-5108
Purity: ≥95%
Packaging: 5mg
Price: $249
Updated: 2024/03/01

Cayman Chemical

Product number: 19167
Product name: MK-5108
Purity: ≥95%
Packaging: 10mg
Price: $437
Updated: 2024/03/01

TRC

Product number: M424995
Product name: MK-5108
Packaging: 10mg
Price: $150
Updated: 2021/12/16

Usbiological

Product number: 474135
Product name: MK 5108
Packaging: 100mg
Price: $2442
Updated: 2021/12/16

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MK-5108 (VX-689) Chemical Properties,Usage,Production

Uses

MK-5108 is a highly selective Aurora-A kinase inhibitor that shows antitumor activity alone and in combination with Docetaxel (D494420).

Definition

ChEBI: 4-(3-chloro-2-fluorophenoxy)-1-[[6-(2-thiazolylamino)-2-pyridinyl]methyl]-1-cyclohexanecarboxylic acid is an aromatic ether.

Biological Activity

mk-5108, also known as vx-689, is a novel, potent and selective inhibitor of aurora a kinase (aak) that competitively binds to the atp binding site of aak and hence potently inhibits the activity of aak with 50% inhibition concentration ic50 value of 0.064 nm. mk-5108 also inhibits other members of aurora kinase family, including aurora b kinase (ic50 = 14 nm) and aurora c kinase (ic50 = 12 nm), with a lesser potency. mk-5108 has been extensively studies and found to exhibit antitumor activity in a wide range of cancer types, including breast, cervix, colorectal, ovary and pancreas neoplasms.myke r. green, bs, pharm.d., bcop, joseph e. woolery, bs, pharm.d, and daruka mahadevan, md, phd. update on aurora kinase targeted therapeutics in oncology. recent pat anticancer drug discov. 2008 november ; 3(3): 162–177.

target

Aurora-A

MK-5108 (VX-689) Preparation Products And Raw materials

Raw materials

Preparation Products

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1010085-13-8, MK-5108 (VX-689)Related Search:

Bortezomib Alisertib (MLN8237) Aurora A Inhibitor I Hesperadin MLN8054 Barasertib (AZD1152-HQPA)

MK-5108

trans-4-(3-Chloro-2-fluorophenoxy)-1-[[6-(2-thiazolylamino)-2-pyridinyl]methyl]cyclohexanecarboxylic acid

VX-689

MK-5108(VX-689)

(1r,4r)-4-(3-chloro-2-fluorophenoxy)-1-((6-(thiazol-2-ylaMino)pyridin-2-yl)Methyl)cyclohexanecarboxylic acid

MK-5198

MK 5108; VX-689; VX 689; MK5108; VX689

CS-545

Cyclohexanecarboxylic acid, 4-(3-chloro-2-fluorophenoxy)-1-[[6-(2-thiazolylamino)-2-pyridinyl]methyl]-, trans-

MK-5108 (VX-689) USP/EP/BP

MK-5108 VX-689 Aurora Kinase Inhibitor

4-(3-chloro-2-fluorophenoxy)-1-[[6-(1,3-thiazol-2-ylamino)pyridin-2-yl]methyl]cyclohexane-1-carboxylic acid

trans-4-(3-Chloro-2-fluorophenoxy)-1-((6-(thiazol-2-ylamino)pyridin-2-yl)methyl)cyclohexane-1-carboxylic acid

1010085-13-8

Inhibitors

Inhibitor