N-Cbz-N-MethylethylenediaMine HCl
- Product Name
- N-Cbz-N-MethylethylenediaMine HCl
- CAS No.
- 162576-01-4
- Chemical Name
- N-Cbz-N-MethylethylenediaMine HCl
- Synonyms
- N-Cbz-N-MethylethylenediaMine HCl;1-CBZ-1-Methyl-ethylenediaMine-HCl;N1-Cbz-N1-methylethane-1,2-diamine Hydrochloride
- CBNumber
- CB62570730
- Molecular Formula
- C11H17ClN2O2
- Formula Weight
- 244.71788
- MOL File
- 162576-01-4.mol
N-Cbz-N-MethylethylenediaMine HCl Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- FB153635
- Product name
- Benzyl (2-aminoethyl)(methyl)carbamate hydrochloride
- Packaging
- 100mg
- Price
- $81
- Updated
- 2021/12/16
- Product number
- FB153635
- Product name
- Benzyl (2-aminoethyl)(methyl)carbamate hydrochloride
- Packaging
- 250mg
- Price
- $162.5
- Updated
- 2021/12/16
- Product number
- W3543
- Product name
- Benzyl(2-aminoethyl)(methyl)carbamatehydrochloride
- Packaging
- 250mg
- Price
- $247
- Updated
- 2021/12/16
- Product number
- FB153635
- Product name
- Benzyl (2-aminoethyl)(methyl)carbamate hydrochloride
- Packaging
- 500mg
- Price
- $275
- Updated
- 2021/12/16
- Product number
- 075967
- Product name
- Benzyl (2-aminoethyl)(methyl)-carbamate hydrochloride
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $297
- Updated
- 2021/12/16
N-Cbz-N-MethylethylenediaMine HCl Chemical Properties,Usage,Production
Synthesis
1221593-52-7
162576-01-4
Preparation 56: Synthesis of benzyl (2-aminoethyl)(methyl)carbamate hydrochloride (C). To a solution of compound B (311 mmol) in methanol (MeOH, 1.2 L) was added a solution of lithium hydroxide (LiOH, 14.9 g, 622 mmol) in water (120 mL). The reaction mixture was stirred at room temperature for 3 hours. The solvent was concentrated under reduced pressure to 75% of the original volume and subsequently diluted with water (400 mL). The solution was extracted with ethyl acetate (EtOAc, 2 x 300 mL). The organic layers were combined, washed with saturated saline (200 mL), dried over anhydrous magnesium sulfate (MgSO4) and concentrated under reduced pressure. The residue was dissolved in ether (300 mL) and treated with 2N hydrochloric acid/ether solution (200 mL). The precipitate formed was collected by filtration, washed with ether and dried under vacuum to afford the hydrochloride of compound C (67.8 g, 89% yield) as a white solid.LC-MS [M + H]+ 209.0 (C11H16N2O2 + H, calculated value: 209.3). Compound C was used directly in the form of N,N-dimethylformamide (DMF) solution for subsequent reactions without further purification.
References
[1] Patent: WO2011/133150, 2011, A1. Location in patent: Page/Page column 295
[2] Patent: US2011/262355, 2011, A1. Location in patent: Page/Page column 107-108
N-Cbz-N-MethylethylenediaMine HCl Preparation Products And Raw materials
Raw materials
Preparation Products
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