(R)-3-(Toluene-4-sulfonyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester

Product Name: (R)-3-(Toluene-4-sulfonyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester
CAS No.: 139986-03-1
Chemical Name: (R)-3-(Toluene-4-sulfonyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester
Synonyms: 1-Boc-(R)-3-(tosyloxy)pyrrolidine;1-Boc-3-pyrrolidinyl (R)-4-Methylbenzenesulfonate;(R)-tert-Butyl 3-(tosyloxy)pyrrolidine-1-carboxylate;tert-butyl (3R)-3-(p-tolylsulfonyloxy)pyrrolidine-1-carboxylate;tert-Butyl 3-(R)-[(4-tolylsulfonyl)oxy]pyrrolidine-1-carboxylate;tert-butyl (3R)-3-(4-methylphenyl)sulfonyloxypyrrolidine-1-carboxylate;(R)-3-(Toluene-4-sulfonyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester;(R)-3-(methylbenzene-4-sulfonylacyloxy)-pyrolidine-1-carboxylic acidtertbutyl ester;1-Pyrrolidinecarboxylic acid, 3-[[(4-methylphenyl)sulfonyl]oxy]-, 1,1-dimethylethyl ester, (3R)-
CBNumber: CB62575472
Molecular Formula: C16H23NO5S
Formula Weight: 341.42
MOL File: 139986-03-1.mol

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(R)-3-(Toluene-4-sulfonyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester Property

storage temp.: 2-8°C
Appearance: White to off-white Solid
optical activity: Consistent with structure

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: 0103DB
Product name: (R)-Tert-Butyl3-(tosyloxy)pyrrolidine-1-carboxylate
Packaging: 100mg
Price: $105
Updated: 2021/12/16

AK Scientific

Product number: 0103DB
Product name: (R)-Tert-Butyl3-(tosyloxy)pyrrolidine-1-carboxylate
Packaging: 250mg
Price: $131
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 34265
Product name: tert-Butyl(R)-3-(tosyloxy)pyrrolidine-1-carboxylate
Purity: 97%
Packaging: 1g
Price: $780
Updated: 2021/12/16

Ambeed

Product number: A145459
Product name: (R)-tert-Butyl3-(tosyloxy)pyrrolidine-1-carboxylate
Purity: 95+%
Packaging: 25g
Price: $1065
Updated: 2021/12/16

Chemenu

Product number: CM197499
Product name: tert-butyl(R)-3-(tosyloxy)pyrrolidine-1-carboxylate
Purity: 95%
Packaging: 5g
Price: $1496
Updated: 2021/12/16

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(R)-3-(Toluene-4-sulfonyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester Chemical Properties,Usage,Production

Synthesis

83220-73-9

98-59-9

139986-03-1

GENERAL STEPS: 1-Boc-3-hydroxy-pyrrolidine (7.3 g, 39 mmol), p-toluenesulfonyl chloride (8.2 g, 43 mmol), triethylamine (9.8 g, 97 mmol), and 4-dimethylaminopyridine (240 mg) were dissolved in dichloromethane (100 mL), and the reaction was stirred for 8 hours at 80 °C. After completion of the reaction, the mixture was cooled to room temperature. The reaction mixture was washed with saturated saline (100 mL) and the organic layer was separated and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure and the resulting crude product was purified by fast silica gel column chromatography to afford tert-butyl (R)-3-(toluene-4-sulfonyloxy)-pyrrolidine-1-carboxylate in quantitative yield.

References

[1] Patent: WO2008/133734, 2008, A2. Location in patent: Page/Page column 40
[2] Patent: WO2009/52065, 2009, A1. Location in patent: Page/Page column 31
[3] Patent: WO2009/52068, 2009, A1. Location in patent: Page/Page column 15; 25-26
[4] Patent: WO2009/52062, 2009, A1. Location in patent: Page/Page column 15; 26-27
[5] Patent: WO2010/65803, 2010, A1. Location in patent: Page/Page column 28-29

(R)-3-(Toluene-4-sulfonyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-3-(Toluene-4-sulfonyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester Suppliers

China 26 India 1 United States 2 Global 29

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139986-03-1, (R)-3-(Toluene-4-sulfonyloxy)-pyrrolidine-1-carboxylic acid tert-butyl esterRelated Search:

(R)-3-(Toluene-4-sulfonyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester

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tert-Butyl 3-(R)-[(4-tolylsulfonyl)oxy]pyrrolidine-1-carboxylate

1-Pyrrolidinecarboxylic acid, 3-[[(4-methylphenyl)sulfonyl]oxy]-, 1,1-dimethylethyl ester, (3R)-

tert-butyl (3R)-3-(p-tolylsulfonyloxy)pyrrolidine-1-carboxylate

tert-butyl (3R)-3-(4-methylphenyl)sulfonyloxypyrrolidine-1-carboxylate

1-Boc-(R)-3-(tosyloxy)pyrrolidine

1-Boc-3-pyrrolidinyl (R)-4-Methylbenzenesulfonate

(R)-3-(methylbenzene-4-sulfonylacyloxy)-pyrolidine-1-carboxylic acidtertbutyl ester

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