diethyl 2-(1-(4-acetaMidophenyl)-1-oxopropan-2-yl)Malonate

Product Name: diethyl 2-(1-(4-acetaMidophenyl)-1-oxopropan-2-yl)Malonate
CAS No.: 81937-39-5
Chemical Name: diethyl 2-(1-(4-acetaMidophenyl)-1-oxopropan-2-yl)Malonate
Synonyms: Granisetron3;Levosimendan Impurity 53;Granisetron Impurity 5 HCl;diethyl 2-(1-(4-acetaMidophenyl)-1-oxopropan-2-yl)Malonate;Propanedioic acid, 2-[2-[4-(acetylamino)phenyl]-1-methyl-2-oxoethyl]-, 1,3-diethyl ester
CBNumber: CB62589312
Molecular Formula: C18H23NO6
Formula Weight: 349.38
MOL File: 81937-39-5.mol

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diethyl 2-(1-(4-acetaMidophenyl)-1-oxopropan-2-yl)Malonate Property

storage temp.: Sealed in dry,Room Temperature

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

AK Scientific

Product number: 2685AC
Product name: Diethyl2-(1-(4-acetamidophenyl)-1-oxopropan-2-yl)malonate
Packaging: 250mg
Price: $309
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0392033
Product name: DIETHYL-2-(1-(4-ACETAMIDOPHENYL)-1-OXOPROPAN-2-YL)MALONATE
Purity: 95.00%
Packaging: 5MG
Price: $498.89
Updated: 2021/12/16

Ambeed

Product number: A211463
Product name: Diethyl2-(1-(4-acetamidophenyl)-1-oxopropan-2-yl)malonate
Purity: 98%
Packaging: 250mg
Price: $51
Updated: 2021/12/16

Ambeed

Product number: A211463
Product name: Diethyl2-(1-(4-acetamidophenyl)-1-oxopropan-2-yl)malonate
Purity: 98%
Packaging: 1g
Price: $111
Updated: 2021/12/16

Alichem

Product number: 81937395
Product name: Diethyl2-(1-(4-acetamidophenyl)-1-oxopropan-2-yl)malonate
Packaging: 250mg
Price: $182.56
Updated: 2021/12/16

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diethyl 2-(1-(4-acetaMidophenyl)-1-oxopropan-2-yl)Malonate Chemical Properties,Usage,Production

Synthesis

81112-08-5

105-53-3

81937-39-5

Example A29: Diethyl malonate (0.16 mol) was slowly added dropwise to a suspension of anhydrous dimethylformamide (90 mL) containing sodium hydride (7.631 g, 0.159 mol) under nitrogen protection. The reaction mixture was heated to 50 °C and maintained for 90 minutes. Subsequently, 1-(4-acetylaminophenyl)-2-chloro-1-propanone (37.462 g, 0.166 mol) was added to the reaction system and the temperature was raised to 80 °C to continue the reaction for 3 hours. Upon completion of the reaction, the mixture was cooled and poured into ice water (1 L), washed with saturated sodium chloride solution, followed by full extraction with ethyl acetate. The organic phases were combined, dried with anhydrous sodium sulfate, filtered and treated with activated carbon and finally concentrated under reduced pressure. The crude product was purified by silica gel column chromatography to give 45.0 g of a colorless oily product in 80% yield with an Rf value of 0.7 (El:EE).IR (KBr) showed absorption peaks at 1747, 1732, 1676 cm^-1 (CO). Mass spectrometry analysis showed a molecular ion peak M+ of 349.

References

[1] Patent: US7230001, 2007, B1. Location in patent: Page/Page column 87
[2] Journal of Heterocyclic Chemistry, 1988, vol. 25, # 6, p. 1689 - 1695

diethyl 2-(1-(4-acetaMidophenyl)-1-oxopropan-2-yl)Malonate Preparation Products And Raw materials

Raw materials

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81937-39-5, diethyl 2-(1-(4-acetaMidophenyl)-1-oxopropan-2-yl)MalonateRelated Search:

3(2H)-Pyridazinone, 4,5-dihydro-5-methyl-6-phenyl-, (5R)- (R)-6-(4-Aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone (S)-3(2h)-Pyridazinone, 6-(4-Aminophenyl)-4,5-Dihydro-5-Methyl- Levosimendan Impurity 8 LevosiMendan iMpurity

diethyl 2-(1-(4-acetaMidophenyl)-1-oxopropan-2-yl)Malonate

Granisetron Impurity 5 HCl

Granisetron3

Propanedioic acid, 2-[2-[4-(acetylamino)phenyl]-1-methyl-2-oxoethyl]-, 1,3-diethyl ester

Levosimendan Impurity 53

81937-39-5