ACS 67
- Product Name
- ACS 67
- CAS No.
- 1088434-86-9
- Chemical Name
- ACS 67
- Synonyms
- ACS 67;ACS 67 Exclusive;JEEWZRQQYWVJCX-WEWVERJPSA-N;5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]-, 4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl ester, (5Z)-
- CBNumber
- CB62590170
- Molecular Formula
- C32H38O5S3
- Formula Weight
- 598.84
- MOL File
- 1088434-86-9.mol
ACS 67 Property
- storage temp.
- Store at -20°C
- solubility
- ≤2mg/ml in ethanol;20mg/ml in DMSO;30mg/ml in dimethyl formamide
- form
- crystalline solid
N-Bromosuccinimide Price
- Product number
- 13619
- Product name
- ACS 67
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $78
- Updated
- 2024/03/01
- Product number
- 13619
- Product name
- ACS 67
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $346
- Updated
- 2024/03/01
- Product number
- 13619
- Product name
- ACS 67
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $614
- Updated
- 2024/03/01
- Product number
- 13619
- Product name
- ACS 67
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $1340
- Updated
- 2024/03/01
- Product number
- C3246
- Product name
- ACS67
- Packaging
- 25mg
- Price
- $1529
- Updated
- 2021/12/16
ACS 67 Chemical Properties,Usage,Production
Uses
ACS-67 is a hydrogen sulphide-releasing derivative of Latanoprost acid. ACS-67 has the potential for glaucoma research[1].
Biological Activity
acs 67 is an analog of latanoprost acid.latanoprost, an f-series prostaglandin (pg) analog, has been approved for use as an ocular hypotensive drug for the treatment of glaucoma clinically. latanoprost is an isopropyl ester, a prodrug form which is converted to free latanoprost acid by endogenous esterase enzymes.
in vitro
in previous study, acs 67 was found to be able to increase the reduced glutathione levels in normotensive pigmented rabbits significantly after single administration in a dose-dependent manner. furthermore, in glaucomatous pigmented rabbits after repeated 5-day administration, acs 67 could also increase the gsh levels when compared with latanoprost. in addition, it was found that acs 67 could significantly increase the cgmp levels in glaucomatous pigmented rabbits and these data with the combination supported that the increase of cgmp was due to the sulfurated moiety of acs 67. moreover, the tolerability was measured in new zealand albino rabbits at three different concentrations of acs 67, and results indicated that acs 67 was very well tolerated in draize test [1].
References
[1] e. perrino, c. uliva, c. lanzi, et al. new prostaglandin derivative for glaucoma treatment. bioorganic & medicinal chemistry letters 19, 1639-1642 (2009).
ACS 67 Preparation Products And Raw materials
Raw materials
Preparation Products
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