BayCysLT2

Product Name: BayCysLT2
CAS No.: 712313-33-2
Chemical Name: BayCysLT2
Synonyms: BayCysLT2;BayCysLT2 Exclusive;GKPAULTWHHPIHX-UHFFFAOYSA-N;Benzoic acid, 3-[[(3-carboxycyclohexyl)amino]carbonyl]-4-[3-[4-(4-phenoxybutoxy)phenyl]propoxy]-
CBNumber: CB62590332
Molecular Formula: C34H39NO8
Formula Weight: 589.68
MOL File: 712313-33-2.mol

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BayCysLT2 Property

Boiling point:: 814.2±65.0 °C(Predicted)
Density: 1.28±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≤20mg/ml in DMSO;20mg/ml in dimethyl formamide
form: crystalline solid
pka: 4.20±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10532
Product name: BayCysLT2
Purity: ≥95%
Packaging: 1mg
Price: $55
Updated: 2024/03/01

Cayman Chemical

Product number: 10532
Product name: BayCysLT2
Purity: ≥95%
Packaging: 5mg
Price: $236
Updated: 2024/03/01

Cayman Chemical

Product number: 10532
Product name: BayCysLT2
Purity: ≥95%
Packaging: 10mg
Price: $420
Updated: 2024/03/01

Cayman Chemical

Product number: 10532
Product name: BayCysLT2
Purity: ≥95%
Packaging: 25mg
Price: $914
Updated: 2024/03/01

ApexBio Technology

Product number: C3883
Product name: BayCysLT2
Packaging: 25mg
Price: $1044
Updated: 2021/12/16

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BayCysLT2 Chemical Properties,Usage,Production

Uses

BayCysLT2, an isophthalic acid derivative, is a selective and potent cysteinyl leukotriene 2 (CysLT2) receptor antagonist with an IC50 value of 53 nM. BayCysLT2 inhibits calcium mobilization induced by leukotriene D4 in HEK293 cells expressing human CysLT2 receptors. BayCysLT2 reverses LTC4-induced increases in coronary artery perfusion pressure and decreases in contractility in isolated perfused guinea pig hearts[1][2].

Definition

ChEBI: Benzoic acid, 3-[[(3-carboxycyclohexyl)amino]carbonyl]-4-[3-[4-(4-phenoxybutoxy)phenyl]propoxy]- is an organooxygen compound and an organonitrogen compound. It is functionally related to a gamma-amino acid.

Biological Activity

baycyslt2, an isophthalic acid derivative, is a selective and potent cyslt2 receptor antagonist [1].cysteinyl leukotrienes (cyslts) belong to a family of g protein-coupled receptors (gpcrs). the cysteinyl leukotrienes (cyslts) are inflammatory mediators associated with neuronal injury after brain ischemia through the activation of their receptors, cyslt1r and cyslt2r [2].

in vitro

baycyslt2 inhibited radioligand binding of ltd4 to cyslt2 and cyslt1 receptor cell lines with ic50 values of 35 and >10,000 nm, respectively [1]. baycyslt2 reversed ltc4-stimulated perfusion pressure increase and contractility decrease in isolated langendorff-perfused guinea pig hearts in a concentration-dependent manner [1]. baycyslt2 protected astrocytes from ischemic injury [3].

in vivo

baycyslt2 attenuated myocardial infarction damage but also inhibited ltd4-induced evans blue dye leakage in the mouse ear vasculature [4].

References

[1] m. harter, j. erguden, f. wunder, et al. isophtalic acid derivatives. 10/537,623, 1-104 (2006).
[2] takasaki j, kamohara m, matsumoto m, et al. the molecular characterization and tissue distribution of the human cysteinyl leukotriene cyslt 2 receptor[j]. biochemical and biophysical research communications, 2000, 274(2): 316-322.
[3] x. j. huang, w.p. zhang, c.t. li, w.z. shi, s.h. fang, y.b. lu, z. chen, e.q. wei. activation of cyslt receptors induces astrocyte proliferation and death after oxygen–glucose deprivation. glia, 56 (2008), pp. 27–37
[4] n. c. ni, d. yan, l.l. ballantyne, a. barajas-espinosa st, t. amand, d.a. pratt, c.d. funk. a selective cysteinyl leukotriene receptor 2 antagonist blocks myocardial ischemia/reperfusion injury and vascular permeability in mice. j. pharmacol. exp. ther., 339 (2011), pp. 768–778

BayCysLT2 Preparation Products And Raw materials

Raw materials

Preparation Products

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712313-33-2, BayCysLT2Related Search:

BayCysLT2

GKPAULTWHHPIHX-UHFFFAOYSA-N

BayCysLT2 Exclusive

Benzoic acid, 3-[[(3-carboxycyclohexyl)amino]carbonyl]-4-[3-[4-(4-phenoxybutoxy)phenyl]propoxy]-

712313-33-2