ChemicalBook > CAS DataBase List > CAY10499

CAY10499

Product Name
CAY10499
CAS No.
359714-55-9
Chemical Name
CAY10499
Synonyms
CAY10499;CAY10499 Exclusive;MAGL-IN-5, 10 mM in DMSO;QTENHWTVRQKWRI-UHFFFAOYSA-N;Benzyl (4-(5-methoxy-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-2-methylphenyl)carbamate;Inhibitor,inhibit,MAGLIN5,MAGL IN 5,FAAH,Fatty acid amide hydrolase,Monoacylglycerol lipase,MAGL;Carbamic acid, N-[4-(5-methoxy-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-2-methylphenyl]-, phenylmethyl ester
CBNumber
CB62590413
Molecular Formula
C18H17N3O5
Formula Weight
355.34
MOL File
359714-55-9.mol
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CAY10499 Property

Density 
1.31±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Soluble in DMSO
form 
crystalline solid
pka
13.31±0.70(Predicted)
color 
Off-white to yellow
InChI
InChI=1S/C18H17N3O5/c1-12-10-14(21-18(23)26-17(20-21)24-2)8-9-15(12)19-16(22)25-11-13-6-4-3-5-7-13/h3-10H,11H2,1-2H3,(H,19,22)
InChIKey
QTENHWTVRQKWRI-UHFFFAOYSA-N
SMILES
C(OCC1=CC=CC=C1)(=O)NC1=CC=C(N2N=C(OC)OC2=O)C=C1C
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML3663
Product name
CAY10499
Purity
≥98% (HPLC)
Packaging
5 mg
Price
$77.14
Updated
2025/07/31
Sigma-Aldrich
Product number
SML3663
Product name
CAY10499
Purity
≥98% (HPLC)
Packaging
25 mg
Price
$328
Updated
2025/07/31
Cayman Chemical
Product number
10007875
Product name
CAY10499
Purity
≥98%
Packaging
1mg
Price
$16
Updated
2024/03/01
Cayman Chemical
Product number
10007875
Product name
CAY10499
Purity
≥98%
Packaging
5mg
Price
$63
Updated
2024/03/01
Cayman Chemical
Product number
10007875
Product name
CAY10499
Purity
≥98%
Packaging
10mg
Price
$109
Updated
2024/03/01
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CAY10499 Chemical Properties,Usage,Production

Description

CAY10499 is a non-selective lipase inhibitor (IC50s = 144, 90, and 14 nM for human recombinant MAGL, HSL, and FAAH, respectively). It also inhibits ATGL, DAGLa, ABHD6, and CES1 by 95, 60, 90, and 95%, respectively, when used at a concentration of 5 mM. CAY10499 inhibits the growth of MCF-7, MDA-MB-231, COV318, and OVCAR-3 cancer cells (IC50s = 4.2, 46, 106.7, and 79.8 μM, respectively). In vivo, CAY10499 reduces FRUC diet- and AIN-93M diet-induced increases in cytosolic lipase activity in rats.

Uses

CAY10499 (MAGL-IN-5) is a non-selective lipase inhibitor with IC50 values of 144 nM and 14 nM for monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH), respectively. Additionally, CAY10499 exhibits anti-inflammatory and antiviral activities[1][2][3][4].

Definition

ChEBI: CAY10499 is a carbamate ester.

in vivo

CAY10499 (intraperitoneal injection; 0.01-10 mg/kg; twice daily; 4 days) exhibits protective and antiviral activities in a mouse model infected with IAV, and can improve the survival rate of mice[2].

References

[1] muccioli g g, labar g, lambert d m. cay10499, a novel monoglyceride lipase inhibitor evidenced by an expeditious mgl assay[j]. chembiochem, 2008, 9(16): 2704-2710.
[2] ben ali y, muller g, petry s, et al. kinetic characterization and specific inhibition of hormone sensitive lipase[c]//chemistry and physics of lipids. elsevier house, brookvale plaza, east park shannon, co, clare, 00000, ireland: elsevier ireland ltd, 2005, 136(2): 155-155.
[3] kraemer f b, shen w j. hormone-sensitive lipase control of intracellular tri-(di-) acylglycerol and cholesteryl ester hydrolysis[j]. journal of lipid research, 2002, 43(10): 1585-1594.

CAY10499 Preparation Products And Raw materials

Raw materials

Preparation Products

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359714-55-9, CAY10499Related Search:


  • CAY10499
  • QTENHWTVRQKWRI-UHFFFAOYSA-N
  • CAY10499 Exclusive
  • Inhibitor,inhibit,MAGLIN5,MAGL IN 5,FAAH,Fatty acid amide hydrolase,Monoacylglycerol lipase,MAGL
  • Carbamic acid, N-[4-(5-methoxy-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-2-methylphenyl]-, phenylmethyl ester
  • Benzyl (4-(5-methoxy-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-2-methylphenyl)carbamate
  • MAGL-IN-5, 10 mM in DMSO
  • 359714-55-9