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CAY10574

Product Name
CAY10574
CAS No.
140651-18-9
Chemical Name
CAY10574
Synonyms
CAN-508;CAY10574;CAN-508 (CAN508);Cdk9 Inhibitor II;CAN508, 10 mM in DMSO;CAY10574, Cdk9 kinase inhibitor;4-((3,5-Diamino-1H-pyrazol-4-yl)diazenyl)phenol;4-[2-(3,5-diamino-1H-pyrazol-4-yl)diazen-1-yl]phenol;Phenol, 4-[2-(3,5-diamino-1H-pyrazol-4-yl)diazenyl]-;CaMKII Inhibitor, CK59 - CAS 140651-18-9 - Calbiochem
CBNumber
CB62590428
Molecular Formula
C9H10N6O
Formula Weight
218.22
MOL File
140651-18-9.mol
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CAY10574 Property

Boiling point:
638.3±55.0 °C(Predicted)
Density 
1.67±0.1 g/cm3(Predicted)
storage temp. 
+2C to +8C
solubility 
DMF: 0.5 mg/ml; DMSO: 0.5 mg/ml
pka
8.52±0.30(Predicted)
form 
Yellow semi-solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
238811
Product name
Cdk9 Inhibitor II - CAS 140651-18-9 - Calbiochem
Packaging
5mg
Price
$289
Updated
2024/03/01
Cayman Chemical
Product number
10011247
Product name
CAY10574
Purity
≥95%
Packaging
1mg
Price
$25
Updated
2024/03/01
Cayman Chemical
Product number
10011247
Product name
CAY10574
Purity
≥95%
Packaging
5mg
Price
$107
Updated
2024/03/01
Cayman Chemical
Product number
10011247
Product name
CAY10574
Purity
≥95%
Packaging
10mg
Price
$186
Updated
2024/03/01
Cayman Chemical
Product number
10011247
Product name
CAY10574
Purity
≥95%
Packaging
50mg
Price
$807
Updated
2024/03/01
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CAY10574 Chemical Properties,Usage,Production

Uses

Cdk9 Inhibitor II is an ATP-competitive inhibitor of Cdk9 and moderate inhibitor of similar enzymes.

Definition

ChEBI: CAN-508 is a member of the class of pyrazoles that is 1H-pyrazole substituted by amino, (4-hydroxyphenyl)diazenyl, and amino groups at positions 3, 4 and 5, respectively. It is a CDK9 inhibitor (IC50 = 0.35 muM) with 38-fold selectivity for CDK9/cyclin T over other CDK/cyclin complexes. It has a role as an angiogenesis inhibitor, an EC 2.7.11.22 (cyclin-dependent kinase) inhibitor, an antineoplastic agent and an apoptosis inducer. It is a member of pyrazoles, a member of phenols, an aromatic amine and a monoazo compound.

General Description

A cell-permeable Olomoucine (Cat. Nos. 495620 & 495624) analog that acts as a CaMKII inhibitor (IC50<10 μM) and inhibits insulin-stimulated glucose uptake (IC50 ≤5 μM) and GLUT4 membrane translocation (IC50 = 100 μM) in 3T3-L1 adipocytes.

Biological Activity

Cell permeable: yes', 'Primary Target
Cdk9', 'Product competes with ATP.', 'Reversible: no', 'Target IC50: 350 nM, using Cdk9/T1

CAY10574 Preparation Products And Raw materials

Raw materials

Preparation Products

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CAY10574 Suppliers

Canada 1 China 41 Ukraine 1 United States 9 Global 52
Toronto Research Chemicals
Tel
--
Fax
--
Email
info@trc-canada.com
Country
Canada
ProdList
6038
Advantage
71

140651-18-9, CAY10574Related Search:


  • CAY10574
  • Cdk9 Inhibitor II
  • 4-[2-(3,5-diamino-1H-pyrazol-4-yl)diazen-1-yl]phenol
  • CAN-508
  • CAN-508 (CAN508)
  • CaMKII Inhibitor, CK59 - CAS 140651-18-9 - Calbiochem
  • inhibit,CAN 508,ATP-competitive,Cyclin dependent kinase,esophageal,cells,CDK,CAN508,Inhibitor,adenocarcinoma,HT-29,CAN-508
  • Phenol, 4-[2-(3,5-diamino-1H-pyrazol-4-yl)diazenyl]-
  • 4-((3,5-Diamino-1H-pyrazol-4-yl)diazenyl)phenol
  • CAY10574, Cdk9 kinase inhibitor
  • CAN508, 10 mM in DMSO
  • 140651-18-9