HAMI3379

Product Name: HAMI3379
CAS No.: 712313-35-4
Chemical Name: HAMI3379
Synonyms: HAMI3379;(Rac)-HAMI 3379;HRJWSEPIRZRGCL-UHFFFAOYSA-N;(Rac) HAMI 3379,(Rac)HAMI 3379;N-(3-carboxy-cyclo-hexyl-)-5-carboxy-2-(cyclo-hexyl-oxy-butyl-oxy-phenyl-propyl-oxy-)-benz-amide;Benzoic acid, 3-[[(3-carboxycyclohexyl)amino]carbonyl]-4-[3-[4-[4-(cyclohexyloxy)butoxy]phenyl]propoxy]-
CBNumber: CB62591197
Molecular Formula: C34H45NO8
Formula Weight: 595.72
MOL File: 712313-35-4.mol

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HAMI3379 Property

Boiling point:: 797.7±60.0 °C(Predicted)
Density: 1.24±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≤5mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide
form: crystalline solid
pka: 4.20±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10580
Product name: HAMI3379
Purity: ≥90%
Packaging: 1mg
Price: $48
Updated: 2023/01/06

Cayman Chemical

Product number: 10580
Product name: HAMI3379
Purity: ≥90%
Packaging: 5mg
Price: $210
Updated: 2023/01/06

Cayman Chemical

Product number: 10580
Product name: HAMI3379
Purity: ≥90%
Packaging: 10mg
Price: $373
Updated: 2023/01/06

Cayman Chemical

Product number: 10580
Product name: HAMI3379
Purity: ≥90%
Packaging: 25mg
Price: $814
Updated: 2023/01/06

ChemScene

Product number: CS-0044263
Product name: HAMI3379
Packaging: 10mg
Price: $1050
Updated: 2021/12/16

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HAMI3379 Chemical Properties,Usage,Production

Definition

ChEBI: Benzoic acid, 3-[[(3-carboxycyclohexyl)amino]carbonyl]-4-[3-[4-[4-(cyclohexyloxy)butoxy]phenyl]propoxy]- is an organooxygen compound and an organonitrogen compound. It is functionally related to a gamma-amino acid.

Biological Activity

hami3379, as a potent cyslt2 receptor antagonist, blocks radioligand binding of ltd4 to cyslt2 and cyslt1 receptor cell lines. in a cyslt2 receptor reporter cell line, hami3379 antagonizes ltd4- and ltc4-induced intracellular calcium mobilization. in contrast, hami3379 exhibits very low potency on a cyslt1 receptor reporter cell line. additionally, hami3379 does not exhibit any agonistic activity on both cyslt2 and cyslt1 receptor cell lines. cyslts ltc4 and ltd4 are potent mediators of hypersensitivity and asthma reactions. they increase the permeability of microvascular, elicit bronchoconstriction, functioning as vasoconstrictors of coronary arteries, which are transduced by cyslt1 and cyslt2.

in vitro

in a murine microglial cell line (bv-2 cells), hami3379 effectively dampened lipopolysaccharide (lps) -induced phagocytosis. in addition, hami3379 dose-dependently decreased the lps-induced overproduction of proinflammatory cytokines which included tumor necrosis factor-α (tnf-α), interleukin-1β (il-1β), and interleukin-6 [1].

in vivo

male sprague–dawley rats were injected intraperitoneally with hami 3379 at a dose of 0.1 mg/kg at 0, 1, 2 and 4 h. after 24 h, hami 3379 attenuated the acute brain injury after middle cerebral artery occlusion (mcao). in addition, hami 3379 weakened the neurological deficits and decreased brain edema, infarct volume, and neuronal loss and degeneration after maco. moreover, hami 3379 blocked the release of interferon-γ, cytokines il-1β, and tnf-α into the cerebrospinal fluid and serum after maco [2].

IC 50

37.9 nm: blocks radioligand binding of leukotriene d4 (ltd4) to cysteinyl leukotriene 2 (cyslt2).

References

[1]. chen, l., yang, y., li, c., zhang, s., zheng, w., wei, e., & zhang, l. cyslt2 receptor mediates lipopolysaccharide-induced microglial inflammation and consequent neurotoxicity in vitro. brain research. 2015; 1624: 433-445.
[2]. shi, q., wang, h., liu, z., fang, s., song, x., & lu, y. et al. hami 3379, a cyslt2r antagonist, dose- and time-dependently attenuates brain injury and inhibits microglial inflammation after focal cerebral ischemia in rats. neuroscience. 2015; 291: 53-69.

HAMI3379 Preparation Products And Raw materials

Raw materials

Preparation Products

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712313-35-4, HAMI3379Related Search:

HAMI3379

HRJWSEPIRZRGCL-UHFFFAOYSA-N

(Rac)-HAMI 3379

(Rac) HAMI 3379,(Rac)HAMI 3379

N-(3-carboxy-cyclo-hexyl-)-5-carboxy-2-(cyclo-hexyl-oxy-butyl-oxy-phenyl-propyl-oxy-)-benz-amide

Benzoic acid, 3-[[(3-carboxycyclohexyl)amino]carbonyl]-4-[3-[4-[4-(cyclohexyloxy)butoxy]phenyl]propoxy]-

712313-35-4

C34H45NO8