ChemicalBook > CAS DataBase List > SPD-304
SPD-304
- Product Name
- SPD-304
- CAS No.
- 869998-49-2
- Chemical Name
- SPD-304
- Synonyms
- CS-2594;SPD-304;CAY10500;SPD-304 Exclusive;TNF Receptor,Tumor Necrosis Factor Receptor,inhibit,SPD-304,SPD 304,SPD304,Inhibitor,TNFR;6,7-dimethyl-3-[[methyl-[2-[methyl-[[1-[3-(trifluoromethyl)phenyl]indol-3-yl]methyl]amino]ethyl]amino]methyl]chromen-4-one;6,7-Dimethyl-3-[[methyl[2-[methyl[[1-[3-(trifluoromethyl)phenyl]-3-indolyl]methyl]amino]ethyl]amino]methyl]-4H-chromen-4-one;4H-1-Benzopyran-4-one, 6,7-dimethyl-3-[[methyl[2-[methyl[[1-[3-(trifluoromethyl)phenyl]-1H-indol-3-yl]methyl]amino]ethyl]amino]methyl]-
- CBNumber
- CB62592538
- Molecular Formula
- C32H32F3N3O2
- Formula Weight
- 547.61
- MOL File
- 869998-49-2.mol
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SPD-304 Property
- Boiling point:
- 589.2±50.0 °C(Predicted)
- Density
- 1.21±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMF: 1 mg/ml; DMSO: 10 mg/ml; Ethanol: 1 mg/ml
- form
- A crystalline solid
- pka
- 7.65±0.50(Predicted)
- color
- White to off-white
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- S1697
- Product name
- SPD304
- Purity
- ≥98% (HPLC), solid
- Packaging
- 1mg
- Price
- $277
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- S1697
- Product name
- SPD304
- Purity
- ≥98% (HPLC), solid
- Packaging
- 5mg
- Price
- $974
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 10008012
- Product name
- SPD-304
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $30
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 10008012
- Product name
- SPD-304
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $56
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 10008012
- Product name
- SPD-304
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $225
- Updated
- 2024/03/01
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SPD-304 Chemical Properties,Usage,Production
Uses
SPD304 has been used in the inhibition of tumor necrosis factor receptor 1 (TNFR1) in dorsal root ganglion neurons and tumor necrosis factor alpha in colonic epithelial cell lines.
Biochem/physiol Actions
SPD304 is a small molecule inhibitor of TNF-a activity with a novel mechanism of action. It interferes with protein-protein interactions on the contact surfaces of the trimeric TNF-a subunits, displacing one of the trimer units, resulting in dissociation of the trimer and loss of activity at the receptor TNFR1. SPD304 inhibits TNFR1 receptor binding to TNF-a with an IC50 of 22μM in vitro and inhibits TNF-a-mediated stimulation of IkB degradation in HeLa cells with an IC50 of 4.6 μM.
SPD-304 Preparation Products And Raw materials
Raw materials
Preparation Products
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