ChemicalBook > CAS DataBase List > tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate

tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate

Product Name
tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate
CAS No.
1181267-36-6
Chemical Name
tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate
Synonyms
Erastin impurity 2;Bilastine Impurity 02;Bilastine Boc Impurity;Bilastine Boc Impurity 32;N-Boc 1-(2-Ethyoxyethyl)-2-(4-piperidinyl)-1H-benzimidazole;tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)pip...;4-(1-(2-ethoxyethyl)-1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate;ert-butyl4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate;tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate;4-[1-(2-Ethoxy-ethyl)-1H-benzoimidazol-2-yl]-piperidine-1-carboxylic acid tert-butyl ester
CBNumber
CB62594138
Molecular Formula
C21H31N3O3
Formula Weight
373.49
MOL File
1181267-36-6.mol
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tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate Property

Boiling point:
521.7±45.0 °C(Predicted)
Density 
1.15±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
pka
5.31±0.10(Predicted)
InChI
InChI=1S/C21H31N3O3/c1-5-26-15-14-24-18-9-7-6-8-17(18)22-19(24)16-10-12-23(13-11-16)20(25)27-21(2,3)4/h6-9,16H,5,10-15H2,1-4H3
InChIKey
WLBGIVZZFISEJL-UHFFFAOYSA-N
SMILES
N1(C(OC(C)(C)C)=O)CCC(C2N(CCOCC)C3=CC=CC=C3N=2)CC1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B619400
Product name
N-Boc1-(2-Ethyoxyethyl)-2-(4-piperidinyl)-1H-benzimidazole
Packaging
100mg
Price
$1055
Updated
2021/12/16
AK Scientific
Product number
Z3424
Product name
tert-Butyl4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate
Packaging
25g
Price
$192
Updated
2021/12/16
Chemenu
Product number
CM161857
Product name
tert-butyl4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate
Purity
95%
Packaging
10g
Price
$194
Updated
2021/12/16
Chemenu
Product number
CM161857
Product name
tert-butyl4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate
Purity
95%
Packaging
25g
Price
$355
Updated
2021/12/16
Crysdot
Product number
CD11339650
Product name
tert-Butyl4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate
Purity
95+%
Packaging
25g
Price
$376
Updated
2021/12/16
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tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate Chemical Properties,Usage,Production

Uses

N-Boc 1-(2-Ethyoxyethyl)-2-(4-piperidinyl)-1H-benzimidazole is an impurity of Bilastine (B385000), which is a novel, nonsedating H1-antihistamine developed for symptomatic treatment of allergic rhinitis and chronic idiopathic urticaria.

Synthesis

628-34-2

953071-73-3

1181267-36-6

To a reaction flask was added 38.00 g of 1-chloro-2-ethoxyethane (Compound 4, 0.35 mol) and 90.4 g of tert-butyl 4-(1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate (Compound 3, 0.3 mol). Under cooling in an ice bath, 7 mL of polyethylene glycol-400 (containing 0.25 mol NaOH and 0.1 mol Na2CO3) was slowly added, and the reaction mixture was stirred vigorously at 40 °C for 2 hours. After completion of the reaction, the reaction solution was cooled to room temperature, extracted with ether, and the organic phase was washed with saturated brine, dried over anhydrous sodium sulfate and filtered. The solvent was removed by distillation under reduced pressure to give 103.1 g tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate (compound 5) in 92% yield.

References

[1] Synthetic Communications, 2011, vol. 41, # 9, p. 1394 - 1402
[2] Patent: CN106146459, 2016, A. Location in patent: Paragraph 0055; 0056; 0057; 0058; 0059; 0060
[3] Patent: WO2014/188453, 2014, A2. Location in patent: Page/Page column 29

tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate 1181267-36-6
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000kg
Release date
2025-06-28
ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Bilastine Impurity 19 1181267-36-6
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
98%
Supply Ability
500mg
Release date
2024-06-28
Shaanxi Dideu New Materials Co. Ltd
Product
tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate 1181267-36-6
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
10000KGS
Release date
2025-02-18

1181267-36-6, tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylateRelated Search:

tert-butyl 4-(1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate Bilastine N-Oxide 1'-Hydroxy Bilastine Bilastine

  • tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate
  • 4-[1-(2-Ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester
  • N-Boc 1-(2-Ethyoxyethyl)-2-(4-piperidinyl)-1H-benzimidazole
  • 4-[1-(2-Ethoxy-ethyl)-1H-benzoimidazol-2-yl]-piperidine-1-carboxylic acid tert-butyl ester
  • 4-(1-(2-ethoxyethyl)-1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate
  • 1-Piperidinecarboxylic acid, 4-[1-(2-ethoxyethyl)-1H-benzimidazol-2-yl]-, 1,1-dimethylethyl ester
  • tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)pip...
  • Bilastine Boc Impurity
  • ert-butyl4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate
  • Bilastine ITS-1 tert-butyl 4-(1-(2-ethoxyethyl)-1Hbenzo[d]iMidazol-2-yl)piperidine-1-carboxylate
  • Erastin impurity 2
  • Bilastine Boc Impurity 32
  • Bilastine Impurity 02
  • 1181267-36-6
  • 181267-36-6
  • C21H31N3O3