2-PyriMidinaMine,4-Methyl-N-[5-Methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]-

ChemicalBook > CAS DataBase List > 2-PyriMidinaMine,4-Methyl-N-[5-Methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]-

2-PyriMidinaMine,4-Methyl-N-[5-Methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]-

Product Name: 2-PyriMidinaMine,4-Methyl-N-[5-Methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]-
CAS No.: 1235318-89-4
Chemical Name: 2-PyriMidinaMine,4-Methyl-N-[5-Methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]-
Synonyms: ADX88178;ADX-88178;ADX88178, >98%;ADX-88178;ADX 88178;ADX88178;4-methyl-N-[5-methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]-2-Pyrimidinamine;5-methyl-N-(4-methylpyrimidin-2-yl)-4-(1H-pyrazol-4-yl)thiazol-2-amine;2-PyriMidinaMine,4-Methyl-N-[5-Methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]-;5-methyl-N-(4-methylpyrimidin-2-yl)-4-(1H-pyrazol-4-yl)-1,3-thiazol-2-amine;Inhibitor,ADX 88178,mGluR,ADX88178,Metabotropic glutamate receptors,inhibit,ADX-88178
CBNumber: CB62594800
Molecular Formula: C12H12N6S
Formula Weight: 272.33
MOL File: 1235318-89-4.mol

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2-PyriMidinaMine,4-Methyl-N-[5-Methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]- Property

storage temp.: Store at -20°C
solubility: DMSO:16.67(Max Conc. mg/mL);61.21(Max Conc. mM)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-6961
Product name: ADX88178
Purity: 99.60%
Packaging: 5mg
Price: $110
Updated: 2021/12/16

ChemScene

Product number: CS-6961
Product name: ADX88178
Purity: 99.60%
Packaging: 10mg
Price: $180
Updated: 2021/12/16

DC Chemicals

Product number: DC10465
Product name: ADX-88178
Purity: >98%
Packaging: 1g
Price: $1600
Updated: 2021/12/16

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2-PyriMidinaMine,4-Methyl-N-[5-Methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]- Chemical Properties,Usage,Production

Description

ADX-88178 is a novel potent, selective, and brain-penetrant positive allosteric modulator of the mGlu4 receptor in rodent models of anxiety, obsessive compulsive disorder (OCD), fear, depression, and psychosis. ADX88178 dose-dependently reduced the number of buried marbles in the marble burying test and increased open-arm exploration in the elevated plus maze (EPM) test, indicative of anxiolytic-like efficacy.

target

ADX88178 is a metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) with an EC50 of 4 nM for human mGluR4.

2-PyriMidinaMine,4-Methyl-N-[5-Methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

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1235318-89-4, 2-PyriMidinaMine,4-Methyl-N-[5-Methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]-Related Search:

2-PyriMidinaMine,4-Methyl-N-[5-Methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]-

5-methyl-N-(4-methylpyrimidin-2-yl)-4-(1H-pyrazol-4-yl)thiazol-2-amine

4-methyl-N-[5-methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]-2-Pyrimidinamine

ADX88178

ADX-88178

5-methyl-N-(4-methylpyrimidin-2-yl)-4-(1H-pyrazol-4-yl)-1,3-thiazol-2-amine

ADX88178, >98%

ADX-88178;ADX 88178;ADX88178

Inhibitor,ADX 88178,mGluR,ADX88178,Metabotropic glutamate receptors,inhibit,ADX-88178

1235318-89-4