5-broMo-7-(trifluoroMethyl)-1H-indazole
- Product Name
- 5-broMo-7-(trifluoroMethyl)-1H-indazole
- CAS No.
- 1374258-43-1
- Chemical Name
- 5-broMo-7-(trifluoroMethyl)-1H-indazole
- Synonyms
- 5-broMo-7-(trifluoroMethyl)-1H-indazole;1H-Indazole, 5-bromo-7-(trifluoromethyl)-
- CBNumber
- CB62594835
- Molecular Formula
- C8H4BrF3N2
- Formula Weight
- 265.03
- MOL File
- 1374258-43-1.mol
5-broMo-7-(trifluoroMethyl)-1H-indazole Property
- storage temp.
- Sealed in dry,Room Temperature
- form
- solid
- color
- White
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- B421205
- Product name
- 5-bromo-7-(trifluoromethyl)-1H-indazole
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- PC402014
- Product name
- 5-Bromo-7-(trifluoromethyl)-1H-indazole
- Packaging
- 100mg
- Price
- $290
- Updated
- 2021/12/16
- Product number
- PC402014
- Product name
- 5-Bromo-7-(trifluoromethyl)-1H-indazole
- Packaging
- 250mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- 3H32-B-27
- Product name
- 5-Bromo-7-(trifluoromethyl)-1H-indazole
- Purity
- 98%
- Packaging
- 100mg
- Price
- $464
- Updated
- 2021/12/16
- Product number
- 3H32-B-27
- Product name
- 5-Bromo-7-(trifluoromethyl)-1H-indazole
- Purity
- 98%
- Packaging
- 250mg
- Price
- $560
- Updated
- 2021/12/16
5-broMo-7-(trifluoroMethyl)-1H-indazole Chemical Properties,Usage,Production
Synthesis
864539-96-8
1374258-43-1
General procedure for the synthesis of 5-bromo-7-(trifluoromethyl)-1H-indazole from 4-bromo-2-methyl-6-(trifluoromethyl)aniline: to a mixture of 4-bromo-2-methyl-6-(trifluoromethyl)aniline (700 mg, 2.77 mmol) and potassium acetate (325.8 mg, 3.32 mmol) in chloroform (20 mL) was added dropwise at 0 °C with acetic anhydride (846.6 mg, 8.30 mmol). The reaction mixture was stirred at room temperature for 1 hour. Subsequently, the reaction mixture was heated to 60 °C and tert-butyl nitrite (570.6 mg, 5.54 mmol) was added. After stirring at 60 °C overnight, the mixture was diluted with water and extracted twice with dichloromethane. The combined organic layers were washed with brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was dissolved in methanol (5 mL) and 6N hydrochloric acid (5 mL). The mixture was stirred at room temperature for 4 hours, alkalized with 10N aqueous sodium hydroxide and extracted twice with dichloromethane. The combined organic layers were again washed with brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (petroleum ether/ethyl acetate = 10:1 to 3:1) to afford 5-bromo-7-(trifluoromethyl)-1H-indazole (420 mg, 57.5% yield) as a yellow oil.LC/MS (ESI) m/z: 265 (M + H).
References
[1] Patent: WO2018/160889, 2018, A1. Location in patent: Page/Page column 561; 562; 563
[2] Patent: US2012/108619, 2012, A1. Location in patent: Page/Page column 37
5-broMo-7-(trifluoroMethyl)-1H-indazole Preparation Products And Raw materials
Raw materials
Preparation Products
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