tert-butyl 6-broMo-2,3-dihydrobenzo[b][1,4]oxazine-4-carboxylate

Product Name: tert-butyl 6-broMo-2,3-dihydrobenzo[b][1,4]oxazine-4-carboxylate
CAS No.: 719310-31-3
Chemical Name: tert-butyl 6-broMo-2,3-dihydrobenzo[b][1,4]oxazine-4-carboxylate
Synonyms: 4-BOC-6-BroMo-2,3-dihydro-1,4-benzoxazine;6-Bromo-4-Boc-2,3-dihydro-benzo[1,4]oxazine;tert-Butyl 6-bromo-2H-benzo[b][1,4]oxazine-4(3H);4-Boc-6-bromo-3,4-dihydro-2H-benzo[b][1,4]oxazine;tert-butyl 6-bromo-2,3-dihydro-1,4-benzoxazine-4-carboxylate;tert-Butyl 6-broMo-2H-benzo[b][1,4]oxazine-4(3H)-carboxylate;tert-butyl 6-broMo-2,3-dihydrobenzo[b][1,4]oxazine-4-carboxylat;tert-butyl 6-broMo-2,3-dihydrobenzo[b][1,4]oxazine-4-carboxylate;1,1-Dimethylethyl 6-bromo-2,3-dihydro-4H-1,4-benzoxazine-4-carboxylate;6-bromo-2,3-dihydrobenzo[1,4]oxazine-4-carboxylic acid tert-butyl ester
CBNumber: CB62597245
Molecular Formula: C13H16BrNO3
Formula Weight: 314.17
MOL File: 719310-31-3.mol

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tert-butyl 6-broMo-2,3-dihydrobenzo[b][1,4]oxazine-4-carboxylate Property

Boiling point:: 377.7±42.0 °C(Predicted)
Density: 1.416±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: -0.03±0.20(Predicted)
Appearance: Colorless to light yellow Liquid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: HCH0045490
Product name: TERT-BUTYL-6-BROMO-2H-BENZO[B][1,4]OXAZINE-4(3H)-CARBOXYLATE
Purity: 95.00%
Packaging: 5MG
Price: $497.23
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 35371
Product name: tert-Butyl6-bromo-2H-benzo[b][1,4]oxazine-4(3H)-carboxylate
Purity: 95+%
Packaging: 1000mg
Price: $598
Updated: 2021/12/16

AK Scientific

Product number: X5526
Product name: tert-Butyl6-bromo-2,3-dihydrobenzo[b][1,4]oxazine-4-carboxylate
Packaging: 5g
Price: $977
Updated: 2021/12/16

Acrotein

Product number: UT00319
Product name: tert-Butyl6-bromo-2H-benzo[b][1,4]oxazine-4(3H)-carboxylate
Purity: 97%
Packaging: 25g
Price: $618.93
Updated: 2021/12/16

Chemenu

Product number: CM123702
Product name: tert-butyl6-bromo-2,3-dihydro-4H-benzo[b][1,4]oxazine-4-carboxylate
Purity: 95%
Packaging: 5g
Price: $798
Updated: 2021/12/16

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tert-butyl 6-broMo-2,3-dihydrobenzo[b][1,4]oxazine-4-carboxylate Chemical Properties,Usage,Production

Synthesis

24424-99-5

105655-01-4

719310-31-3

The reaction was carried out with 6-bromo-3,4-dihydro-2H-benzo[b][1,4]oxazine (1.37 g, 6.4 mmol) and di-tert-butyl dicarbonate (1.676 g, 7.68 mmol) in the presence of triethylamine (970 mg) and 4-dimethylaminopyridine (78 mg, 0.64 mmol), stirred at room temperature in tetrahydrofuran (27 mL). mixture overnight. After completion of the reaction, the mixture was diluted with water (200 mL) and extracted with ethyl acetate (100 mL). The organic layer was washed sequentially with water (50 mL) and brine, dried over anhydrous sodium sulfate and concentrated to afford the target product tert-butyl 6-bromo-2H-benzo[b][1,4]oxazine-4(3H)-carboxylate (1.3 g, 65% yield) as a yellow oil.LC-MS analysis showed the [M-55]+ peak was located at m/z 258.1H NMR (400 MHz, DMSO- d6) δ 1.49 (s, 9H), 3.78 (t, J = 4.8 Hz, 2H), 4.21 (t, J = 4.4 Hz, 2H), 6.83 (d, J = 4.4 Hz, 1H), 7.12 (dd, J1 = 2.0 Hz, J2 = 8.4 Hz, 2H), 8.01 (s, 1H).

References

[1] Patent: WO2011/130628, 2011, A1. Location in patent: Page/Page column 227
[2] Patent: US2013/102595, 2013, A1. Location in patent: Paragraph 0575
[3] Patent: JP2015/187145, 2015, A. Location in patent: Paragraph 0488
[4] Patent: WO2008/44022, 2008, A1. Location in patent: Page/Page column 32

tert-butyl 6-broMo-2,3-dihydrobenzo[b][1,4]oxazine-4-carboxylate Preparation Products And Raw materials

Raw materials

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tert-butyl 6-broMo-2,3-dihydrobenzo[b][1,4]oxazine-4-carboxylate Suppliers

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719310-31-3, tert-butyl 6-broMo-2,3-dihydrobenzo[b][1,4]oxazine-4-carboxylateRelated Search:

tert-butyl 6-broMo-2,3-dihydrobenzo[b][1,4]oxazine-4-carboxylate

6-bromo-2,3-dihydrobenzo[1,4]oxazine-4-carboxylic acid tert-butyl ester

4-Boc-6-bromo-3,4-dihydro-2H-benzo[b][1,4]oxazine

4H-1,4-Benzoxazine-4-carboxylic acid, 6-broMo-2,3-dihydro-, 1,1-diMethylethyl ester

tert-Butyl 6-broMo-2H-benzo[b][1,4]oxazine-4(3H)-carboxylate

4-BOC-6-BroMo-2,3-dihydro-1,4-benzoxazine

6-Bromo-4-Boc-2,3-dihydro-benzo[1,4]oxazine

tert-butyl 6-broMo-2,3-dihydrobenzo[b][1,4]oxazine-4-carboxylat

tert-Butyl 6-bromo-2H-benzo[b][1,4]oxazine-4(3H)

tert-butyl 6-bromo-2,3-dihydro-1,4-benzoxazine-4-carboxylate

1,1-Dimethylethyl 6-bromo-2,3-dihydro-4H-1,4-benzoxazine-4-carboxylate

719310-31-3