4-(5-AMino-1H-pyrazol-3-yl)piperidin-1-carboxylic acid tert-butyl ester

Product Name: 4-(5-AMino-1H-pyrazol-3-yl)piperidin-1-carboxylic acid tert-butyl ester
CAS No.: 1169563-99-8
Chemical Name: 4-(5-AMino-1H-pyrazol-3-yl)piperidin-1-carboxylic acid tert-butyl ester
Synonyms: tert-Butyl 4-(5-amino-1H-pyrazol-3-yl)piperidine-1-carboxylate;4-(5-AMino-1H-pyrazol-3-yl)piperidin-1-carboxylic acid tert-butyl ester;4-(5-AMino-1H-pyrazol-3-yl)-piperidine-1-carboxylic acid tert-butyl ester;1-Piperidinecarboxylic acid, 4-(5-amino-1H-pyrazol-3-yl)-, 1,1-dimethylethyl ester
CBNumber: CB62598484
Molecular Formula: C13H22N4O2
Formula Weight: 266.34
MOL File: 1169563-99-8.mol

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4-(5-AMino-1H-pyrazol-3-yl)piperidin-1-carboxylic acid tert-butyl ester Property

Boiling point:: 465.1±45.0 °C(Predicted)
Density: 1.195±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
pka: 15.40±0.10(Predicted)
Appearance: Off-white to light yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: Y7162
Product name: 4-(5-Amino-1H-pyrazol-3-yl)-piperidine-1-carboxylicacidtert-butylester
Packaging: 1g
Price: $436
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0394133
Product name: TERT-BUTYL-4-(5-AMINO-1H-PYRAZOL-3-YL)PIPERIDINE-1-CARBOXYLATE
Purity: 95.00%
Packaging: 5MG
Price: $497.07
Updated: 2021/12/16

Matrix Scientific

Product number: 068940
Product name: 4-(5-Amino-1H-pyrazol-3-yl)-piperidine-1-carboxylic acid tert-butyl ester
Purity: >95%
Packaging: 500mg
Price: $550
Updated: 2021/12/16

Matrix Scientific

Product number: 068940
Product name: 4-(5-Amino-1H-pyrazol-3-yl)-piperidine-1-carboxylic acid tert-butyl ester
Purity: >95%
Packaging: 250mg
Price: $358
Updated: 2021/12/16

Matrix Scientific

Product number: 068940
Product name: 4-(5-Amino-1H-pyrazol-3-yl)-piperidine-1-carboxylic acid tert-butyl ester
Purity: >95%
Packaging: 1g
Price: $840
Updated: 2021/12/16

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4-(5-AMino-1H-pyrazol-3-yl)piperidin-1-carboxylic acid tert-butyl ester Chemical Properties,Usage,Production

Synthesis

660406-84-8

1169563-99-8

To a 5 mL conical reaction vial was added tert-butyl 4-(2-cyanoacetyl)piperidine-1-carboxylate (348 mg, 1.379 mmol), hydrazine monohydrate (329.4 μL, 6.896 mmol) and anhydrous ethanol (4 mL). The reaction vial was sealed and the reaction was stirred in an oil bath at 80 °C for 20 h. The reaction was carried out under pressure and vaporized. After completion of the reaction, the solvent was removed by distillation under reduced pressure to afford tert-butyl 4-(5-amino-1H-pyrazol-3-yl)piperidine-1-carboxylate as a pale yellow foamy solid (367 mg, 99% yield).

References

[1] Patent: WO2009/111279, 2009, A1. Location in patent: Page/Page column 87
[2] Patent: WO2011/45344, 2011, A1. Location in patent: Page/Page column 88-89
[3] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 6, p. 677 - 682
[4] Patent: WO2016/138532, 2016, A1. Location in patent: Paragraph 0252

4-(5-AMino-1H-pyrazol-3-yl)piperidin-1-carboxylic acid tert-butyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(5-AMino-1H-pyrazol-3-yl)piperidin-1-carboxylic acid tert-butyl ester Suppliers

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1169563-99-8, 4-(5-AMino-1H-pyrazol-3-yl)piperidin-1-carboxylic acid tert-butyl esterRelated Search:

4-(5-AMino-1H-pyrazol-3-yl)piperidin-1-carboxylic acid tert-butyl ester

4-(5-AMino-1H-pyrazol-3-yl)-piperidine-1-carboxylic acid tert-butyl ester

tert-Butyl 4-(5-amino-1H-pyrazol-3-yl)piperidine-1-carboxylate

1-Piperidinecarboxylic acid, 4-(5-amino-1H-pyrazol-3-yl)-, 1,1-dimethylethyl ester

1169563-99-8