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1-Methyl-1H-indol-4-ol

Product Name
1-Methyl-1H-indol-4-ol
CAS No.
7556-37-8
Chemical Name
1-Methyl-1H-indol-4-ol
Synonyms
1-methylindol-4-ol;1-Methyl-1H-indol-4-ol;1H-Indol-4-ol, 1-methyl-
CBNumber
CB62603603
Molecular Formula
C9H9NO
Formula Weight
147.17
MOL File
7556-37-8.mol
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1-Methyl-1H-indol-4-ol Property

Melting point:
90 °C
Boiling point:
316.8±15.0 °C(Predicted)
Density 
1.15±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
10.07±0.40(Predicted)
Appearance
Off-white to light brown Solid
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
M220478
Product name
1-Methyl-1H-Indol-4-ol
Packaging
500mg
Price
$265
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0380758
Product name
1-METHYL-1H-INDOL-4-OL
Purity
95.00%
Packaging
5MG
Price
$500.87
Updated
2021/12/16
AK Scientific
Product number
W8279
Product name
1-Methyl-1H-indol-4-ol
Packaging
25g
Price
$1873
Updated
2021/12/16
Ambeed
Product number
A127758
Product name
1-Methyl-1H-indol-4-ol
Purity
97%
Packaging
250mg
Price
$50
Updated
2021/12/16
Ambeed
Product number
A127758
Product name
1-Methyl-1H-indol-4-ol
Purity
97%
Packaging
1g
Price
$131
Updated
2021/12/16
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1-Methyl-1H-indol-4-ol Chemical Properties,Usage,Production

Synthesis

13523-93-8

7556-37-8

b) Synthesis of 4-hydroxy-1-methylindole: In a hydrogenation unit, 4-(benzyloxy)-1-methyl-1H-indole (0.250 g, 1.12 mmol) was dissolved in methanol (2.25 mL) to form a brown solution. To this solution was added 5% Pd/C catalyst (0.119 g, 1.12 mmol, pre-dried in an oven). The mixture was connected to a hydrogenation unit and after three degassing operations, it was charged with hydrogen. After the last degassing, the reaction was shaken at 40 psi hydrogen pressure for 16 hours. Upon completion of the reaction, the reaction mixture was diluted with methanol (15 mL), filtered through a layer of diatomaceous earth (2.5 inches at a flow rate of 2 L/h) and washed with warm methanol (75 mL). The organic filtrate was concentrated to give 0.160 g (97% yield) of a black oily product. The product was characterized by 1H NMR (CDCl3): δ 7.07 (t, J = 8.24 Hz, 1H), 6.92 (m, J = 8.24 Hz, 2H), 6.52 (m, J = 2.47 Hz, 2H), 4.60 (br s, 1H), 3.75 (s, 3H).

References

[1] Patent: US2006/104998, 2006, A1. Location in patent: Page/Page column 20
[2] Journal of Medicinal Chemistry, 2008, vol. 51, # 3, p. 417 - 423
[3] Patent: CN108358760, 2018, A. Location in patent: Paragraph 0046
[4] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 17, p. 4090 - 4094
[5] Patent: CN103254191, 2016, B. Location in patent: Paragraph 0134; 0135

1-Methyl-1H-indol-4-ol Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Methyl-1H-indol-4-ol Suppliers

China 42 India 2 United States 1 Global 45
Shanghai yirong biology science and technology co., ltd
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18049974220
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+86 (21) 51062076
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Wuhan TCASChem Technology Co., Ltd.
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027-86697669 13986148687
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86-027-86697669
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sales@tcaschem.com
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15026594951
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0556-5030632
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rs@raise-chem.com
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China
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Bide Pharmatech Ltd.
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400-164-7117 13681763483
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+86-21-61629029
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product02@bidepharm.com
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Shanghai HuanChuan Industry Co.,Ltd.
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021-61478794
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sales@hcshhai.com
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Shanghai Kahn Pharmaceutical Co., Ltd.
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021-34979681; 17701870669
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Amadis Chemical Company Limited
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Shanghai Civic Chemical Technology Co., Ltd.
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2018
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Shanghai CR Corporation Limited
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13062833949; 4006653949 4006653949
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Hangzhou Molcore Biopharmatech Co.,Ltd
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7556-37-8, 1-Methyl-1H-indol-4-olRelated Search:

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