3-aMino-6-broMo-2-pyridinecarboxylic acid
- Product Name
- 3-aMino-6-broMo-2-pyridinecarboxylic acid
- CAS No.
- 1052708-46-9
- Chemical Name
- 3-aMino-6-broMo-2-pyridinecarboxylic acid
- Synonyms
- 3-aMino-6-broMopicolinic acid;3-aMino-6-broMo-2-pyridinecarboxylic acid;2-Pyridinecarboxylic acid, 3-amino-6-bromo-
- CBNumber
- CB62605566
- Molecular Formula
- C6H5BrN2O2
- Formula Weight
- 217.02
- MOL File
- 1052708-46-9.mol
3-aMino-6-broMo-2-pyridinecarboxylic acid Property
- Boiling point:
- 412.2±45.0 °C(Predicted)
- Density
- 1.909±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 3.99±0.10(Predicted)
- form
- solid
- color
- White to off-white
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A602223
- Product name
- 3-Amino-6-bromopicolinicAcid
- Packaging
- 100mg
- Price
- $265
- Updated
- 2021/12/16
- Product number
- HCH0364342
- Product name
- 3-AMINO-6-BROMOPICOLINIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.53
- Updated
- 2021/12/16
- Product number
- OR510100
- Product name
- 3-Amino-6-bromopicolinic acid
- Purity
- >98%
- Packaging
- 250mg
- Price
- $185
- Updated
- 2021/12/16
- Product number
- UT01776
- Product name
- 3-Amino-6-bromopicolinicacid
- Purity
- 97%
- Packaging
- 1g
- Price
- $511.1
- Updated
- 2021/12/16
- Product number
- 1052708469
- Product name
- 3-Amino-6-bromopicolinicacid
- Packaging
- 1g
- Price
- $608.16
- Updated
- 2021/12/16
3-aMino-6-broMo-2-pyridinecarboxylic acid Chemical Properties,Usage,Production
Synthesis
866775-09-9
1052708-46-9
General procedure for the synthesis of 3-amino-6-bromopyridine-2-carboxylic acid from methyl 3-amino-6-bromopyridinecarboxylate (Step 3): methyl 3-methyl-3-amino-6-bromopyridine-2-carboxylate (10 g, 43.28 mmol) was dissolved in a solvent mixture of THF and methanol (2:1, v/v, 142 mL). To this solution was added 1 M aqueous lithium hydroxide (71 mL) at room temperature and the reaction mixture was stirred for 16 hours at room temperature. Upon completion of the reaction, 1N hydrochloric acid (71 mL) was added to the mixture for acidification. Subsequently, the mixture was concentrated under reduced pressure to remove the solvent. The precipitate was collected by filtration and the crude product was washed with cold water to yield 3-amino-6-bromopyridine-2-carboxylic acid (9.0 g, 96% yield) as an off-white solid. The product was characterized by 1H-NMR (400 MHz, DMSO-D6): δ 6.50-7.05 (1H, broad single peak), 7.18 (1H, d, J=8.76 Hz), 7.42 (1H, d, J=8.76 Hz), 11.20-13.80 (1H, broad single peak). Note: No proton signal was observed for carboxylic acid (CO2H).
References
[1] Patent: WO2008/106692, 2008, A1. Location in patent: Page/Page column 122-123
[2] Patent: EP2975031, 2016, A1. Location in patent: Paragraph 1072
3-aMino-6-broMo-2-pyridinecarboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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