Glycine, N-(phenylMethyl)-, Methyl ester
- Product Name
- Glycine, N-(phenylMethyl)-, Methyl ester
- CAS No.
- 53386-64-4
- Chemical Name
- Glycine, N-(phenylMethyl)-, Methyl ester
- Synonyms
- N-Benzylglycine Methyl Ester;N-(phenylmethyl)glycine methyl ester;Benzylamino-acetic acid methyl ester;Glycine, N-(phenylMethyl)-, Methyl ester
- CBNumber
- CB62610342
- Molecular Formula
- C10H13NO2
- Formula Weight
- 179.22
- MOL File
- 53386-64-4.mol
Glycine, N-(phenylMethyl)-, Methyl ester Property
- Boiling point:
- 130-132 °C(Press: 6 Torr)
- Density
- 1.069±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 6.46±0.20(Predicted)
- Appearance
- Colorless to light yellow Liquid
Safety
- RIDADR
- 3265
- HazardClass
- 8
- PackingGroup
- Ⅲ
N-Bromosuccinimide Price
- Product number
- CS-W022790
- Product name
- Methyl2-(benzylamino)acetate
- Packaging
- 5g
- Price
- $104
- Updated
- 2021/12/16
- Product number
- CHM0122294
- Product name
- METHYL 2-(BENZYLAMINO)ACETATE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $808.89
- Updated
- 2021/12/16
- Product number
- CHM0122294
- Product name
- METHYL 2-(BENZYLAMINO)ACETATE
- Purity
- 95.00%
- Packaging
- 2.5G
- Price
- $1147.43
- Updated
- 2021/12/16
- Product number
- CHM0122294
- Product name
- METHYL 2-(BENZYLAMINO)ACETATE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1421.65
- Updated
- 2021/12/16
- Product number
- A606442
- Product name
- Methyl2-(benzylamino)acetate
- Purity
- 98%
- Packaging
- 250mg
- Price
- $10
- Updated
- 2021/12/16
Glycine, N-(phenylMethyl)-, Methyl ester Chemical Properties,Usage,Production
Synthesis
96-32-2
100-46-9
53386-64-4
The general procedure for the synthesis of methyl 2-(benzylamino)acetate from methyl bromoacetate and benzylamine was as follows: the flame-dried flask was cooled under nitrogen protection and a tetrahydrofuran (THF, 10 mL, 1 M) solution of benzylamine (2.36 mL, 21.6 mmol) was added. The reaction system was cooled to 0 °C, followed by slow dropwise addition of methyl bromoacetate (0.93 mL, 9.8 mmol). The reaction mixture was controlled to gradually warm up to room temperature over 2.5 h and the progress of the reaction was monitored by thin layer chromatography (TLC) until the feedstock was completely consumed. After completion of the reaction, the mixture was concentrated under reduced pressure and the resulting residue was dissolved in ether (Et2O) and filtered. The filtrate was concentrated again under reduced pressure and the crude product was purified by fast column chromatography to give 1.12 g (63% yield) of methyl 2-(benzylamino)acetate as a colorless oil. Its nuclear magnetic resonance hydrogen spectrum (1H NMR, 500 MHz, CDCl3) data were as follows: δ 7.30 (d, J = 4.3 Hz, 4H), 7.29-7.24 (m, 1H), 3.81 (s, 2H), 3.73 (s, 3H), 3.43 (s, 2H), 1.93 (s, br, 1H), which is in accordance with the literature reports.
References
[1] Journal of Labelled Compounds and Radiopharmaceuticals, 2001, vol. 44, # 12, p. 831 - 841
[2] Patent: US2002/151546, 2002, A1
[3] Bulletin de la Societe Chimique de France, 1993, vol. 130, p. 584 - 596
[4] Journal of Organic Chemistry, 1998, vol. 63, # 8, p. 2442 - 2450
[5] Tetrahedron Letters, 2015, vol. 56, # 23, p. 3393 - 3395
Glycine, N-(phenylMethyl)-, Methyl ester Preparation Products And Raw materials
Raw materials
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