(S)-(+)-2-(N-MethylaMino)-3-phenylpropanol
- Product Name
- (S)-(+)-2-(N-MethylaMino)-3-phenylpropanol
- CAS No.
- 84773-29-5
- Chemical Name
- (S)-(+)-2-(N-MethylaMino)-3-phenylpropanol
- Synonyms
- N-Me-L-Phe-Ol;H-N-Me-Phe-ol;-2-(Methylamino);N-Me-Phenylalaninol;N-Me-D-Phenylalaninol;N-Methyl-L-phenylalaninol;N-methyl-D-phenylpropanol;N-Methyl-(S)-phenylalaninol;(S)-2-(Methylamino)-3-phenyl-1-propanol;(S)-2-(MethylaMino)-3-phenylpropan-1-ol
- CBNumber
- CB62614133
- Molecular Formula
- C10H15NO
- Formula Weight
- 165.23
- MOL File
- 84773-29-5.mol
(S)-(+)-2-(N-MethylaMino)-3-phenylpropanol Property
- Melting point:
- 68-70℃
- Boiling point:
- 294.9±20.0 °C(Predicted)
- Density
- 1.020±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 14.75±0.10(Predicted)
- Appearance
- White to off-white Solid
- optical activity
- Consistent with structure
Safety
- RIDADR
- UN3259
- HazardClass
- 8
- HS Code
- 2922190090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
H318Causes serious eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- PH008400
- Product name
- (2S)-2-(methylamino)-3-phenyl-1-propanol
- Purity
- AldrichCPR
- Packaging
- 25MG
- Price
- $172
- Updated
- 2023/06/20
- Product number
- OR917507
- Product name
- (S)-2-(Methylamino)-3-phenylpropan-1-ol
- Purity
- 95%
- Packaging
- 250mg
- Price
- $305
- Updated
- 2021/12/16
- Product number
- 3046AC
- Product name
- (S)-2-(Methylamino)-3-phenylpropan-1-ol
- Packaging
- 1g
- Price
- $492
- Updated
- 2021/12/16
- Product number
- CCH0033275
- Product name
- (S)-2-(METHYLAMINO)-3-PHENYLPROPAN-1-OL
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.98
- Updated
- 2021/12/16
- Product number
- CCH0033275
- Product name
- (S)-2-(METHYLAMINO)-3-PHENYLPROPAN-1-OL
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $630
- Updated
- 2021/12/16
(S)-(+)-2-(N-MethylaMino)-3-phenylpropanol Chemical Properties,Usage,Production
Uses
N-Methyl-(S)-phenylalaninol is used in the synthesis of cyclopropane-fused oxazepanones which have antimycobacterial properties.
Synthesis
264128-49-6
84773-29-5
General procedure for the synthesis of (S)-(+)-2-(N-methylamino)-3-phenyl-1-propanol from 2-Boc-methylamino-3-phenyl-1-propanol: M: Deprotection of acid-unstable protecting groups (version 1) Dissolve 5 mmol of the feedstock in a wet trifluoroacetic acid-dichloromethane mixture (1:1, v/v) and stir the reaction for 4-7 hours. After completion of the reaction, the solvent was removed from the reaction mixture by evaporation. The residue was dissolved in dichloromethane and evaporated again to completely remove the residual trifluoroacetic acid. This dissolution-evaporation process was repeated three times to ensure complete removal of the acid. Finally, the residue was purified by column chromatography (using a dichloromethane-pentane gradient elution with an amino stationary phase) to give the target product. b) Synthesis of (S)-2-methylamino-3-phenyl-propan-1-ol (Ib) Compound Ia was subjected to deprotection reaction according to General Method M. Compound Ib was successfully obtained in 77% yield (630 mg, 3.8 mmol). Mass spectrometry (MS-ESI) analysis showed m/z 166 ([M + H]+, 100%). The results of the elemental analysis were consistent with the theoretical values: calculated values (%): C 72.69, H 9.15, N 8.48; measured values (%): C 72.66, H 9.13, N 8.47.
References
[1] Patent: WO2009/52970, 2009, A2. Location in patent: Page/Page column 68; 71
(S)-(+)-2-(N-MethylaMino)-3-phenylpropanol Preparation Products And Raw materials
Raw materials
Preparation Products
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