Pyridine, 3-(4,5-dihydro-2-oxazolyl)-

Product Name: Pyridine, 3-(4,5-dihydro-2-oxazolyl)-
CAS No.: 40055-37-6
Chemical Name: Pyridine, 3-(4,5-dihydro-2-oxazolyl)-
Synonyms: Nicorandil Impurity 3;Nicodil EP impuritiy 1;Nicorandil EP Impurity 4;Nicorandil EP Impurity D;2-(3-Pyridyl)-2-oxazoline;2-Pyridin-3-yl-2-oxazoline;2-(Pyridin-3-yl)-4,5-dihydrooxazole;Pyridine, 3-(4,5-dihydro-2-oxazolyl)-;2-pyridin-3-yl-4,5-dihydro-1,3-oxazole;Nicorandil Impurity 4(Nicorandil EP Impurity D)
CBNumber: CB62617013
Molecular Formula: C8H8N2O
Formula Weight: 148.16
MOL File: 40055-37-6.mol

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Pyridine, 3-(4,5-dihydro-2-oxazolyl)- Property

Melting point:: 71 °C
Boiling point:: 260 °C
Density: 1.23±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
form: Solid
pka: 4.13±0.12(Predicted)
color: Off-White to Pale Yellow
Stability:: Hygroscopic
InChI: InChI=1S/C8H8N2O/c1-2-7(6-9-3-1)8-10-4-5-11-8/h1-3,6H,4-5H2
InChIKey: FVASBRDDSBRETH-UHFFFAOYSA-N
SMILES: C1=NC=CC=C1C1=NCCO1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: BP1106
Product name: Nicorandil amide
Purity: British Pharmacopoeia (BP) Reference Standard
Packaging: 10MG
Price: $218
Updated: 2025/07/31

TRC

Product number: P995715
Product name: 2-(3-Pyridyl)-2-oxazoline
Packaging: 500mg
Price: $165
Updated: 2021/12/16

AK Scientific

Product number: 6961CD
Product name: 2-(Pyridin-3-yl)-4,5-dihydrooxazole
Packaging: 100mg
Price: $190
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0025962
Product name: 2-(3-PYRIDYL)-2-OXAZOLINE
Purity: 95.00%
Packaging: 5MG
Price: $499.35
Updated: 2021/12/16

Ambeed

Product number: A220351
Product name: 2-(Pyridin-3-yl)-4,5-dihydrooxazole
Purity: 97%
Packaging: 5g
Price: $1328
Updated: 2021/12/16

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Pyridine, 3-(4,5-dihydro-2-oxazolyl)- Chemical Properties,Usage,Production

Uses

2-(3-Pyridyl)-2-oxazoline is an impurity of Nicorandil (N398500). Nicorandil impurity E.

Synthesis

500-22-1

141-43-5

40055-37-6

General procedure for the synthesis of 3-(4,5-dihydro-2-oxazolyl)-pyridine from 3-pyridinecarboxaldehyde and 2-aminoethanol: To a solution of 3-pyridinecarboxaldehyde (79 mg, 0.5 mmol), 2-aminoethanol (200 μL, 3.2 mmol), and pyridine (80 μL, 1.0 mmol) in methanol (6 mL) was added PTAB (trimethylphenyltrimethyl ammonium trimethylammonium tribromide, 376 mg, 1.0 mmol). The reaction mixture was stirred at room temperature for 22 hours and then treated with 0.5 M aqueous Na2S2O3 (10 mL) and 1.0 M aqueous NaHCO3 (15 mL), followed by extraction with EtOAc (60 mL). The organic layer was washed sequentially with 0.5 M Na2S2O3 aqueous solution and saturated NaCl aqueous solution and dried with MgSO4. After the solvent was removed under vacuum, the residue was purified by column chromatography on silica gel (Wako C-200), the eluent being a mixture of CCl4 and CCl4-CHCl3 (2:1 v/v) to afford 3-(4,5-dihydro-2-oxazolyl)-pyridine (85 mg) in 86% yield.

References

[1] Heterocycles, 2017, vol. 94, # 5, p. 979 - 990

Pyridine, 3-(4,5-dihydro-2-oxazolyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

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Pyridine, 3-(4,5-dihydro-2-oxazolyl)- Suppliers

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View Lastest Price from Pyridine, 3-(4,5-dihydro-2-oxazolyl)- manufacturers

Moxin Chemicals

Product: Nicorandil Impurity D 40055-37-6
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 95%+
Supply Ability: 100000
Release date: 2025-01-15

40055-37-6, Pyridine, 3-(4,5-dihydro-2-oxazolyl)-Related Search:

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Pyridine, 3-(4,5-dihydro-2-oxazolyl)-

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2-pyridin-3-yl-4,5-dihydro-1,3-oxazole

2-(Pyridin-3-yl)-4,5-dihydrooxazole

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40055-37-6