ALK inhibitor 2

ChemicalBook > CAS DataBase List > ALK inhibitor 2

Product Name: ALK inhibitor 2
CAS No.: 761438-38-4
Chemical Name: ALK inhibitor 2
Synonyms: ALK inhibitor 2;2-[[5-chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methyl-;2-[[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]amino]-N-methylbenzenesulfonamide;2-((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-N-methylbenzenesulfonamide;2-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methylbenzenesulfonamide;BenzenesulfonaMide, 2-[[5-chloro-2-[[2-Methoxy-4-(4-Methyl-1-piperazinyl)phenyl]aMino]-4-pyriMidinyl]aMino]-N-Methyl-;2-[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]-N-methylbenzene-1-sulfonamide;ALK tyrosine kinase receptor,kinase,Anaplastic lymphoma kinase (ALK),Anaplastic lymphoma kinase,CD246,testis-specific,ALK inhibitor 2,serine/threonine,adhesion,Inhibitor,focal,PTK2 protein tyrosine kinase 2,PTK2,contraception,Cluster of differentiation 246,reversible,ALK inhibitor-2,ALK inhibitor2,inhibit,FAK,Focal adhesion kinase,TSSK2,male
CBNumber: CB62624075
Molecular Formula: C23H28ClN7O3S
Formula Weight: 518.03
MOL File: 761438-38-4.mol

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ALK inhibitor 2 Property

Boiling point:: 712.4±70.0 °C(Predicted)
Density: 1.371±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Powder
pka: 11.27±0.10(Predicted)
color: White to gray

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0796
Product name: ALKinhibitor2
Purity: 99.77%
Packaging: 5mg
Price: $307
Updated: 2021/12/16

ApexBio Technology

Product number: A3155
Product name: ALKinhibitor2
Packaging: 5mg
Price: $375
Updated: 2021/12/16

ChemScene

Product number: CS-0796
Product name: ALKinhibitor2
Purity: 99.77%
Packaging: 10mg
Price: $430
Updated: 2021/12/16

ApexBio Technology

Product number: A3155
Product name: ALKinhibitor2
Packaging: 10mg
Price: $524
Updated: 2021/12/16

Ambeed

Product number: A524942
Product name: ALKinhibitor2
Purity: 98+%
Packaging: 250mg
Price: $576
Updated: 2021/12/16

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ALK inhibitor 2 Chemical Properties,Usage,Production

Biological Activity

ALK inhibitor 2 (compound 18) is a potent, pyrimidine ALK inhibitor. It is a potent testis-specific serine/threonine kinase 2 (TSSK2; IC50=37 nM) and focal adhesion kinase (FAK; IC50=5 nM) inhibitor.

in vitro

Testis-specific serine/threonine kinase 2 (TSSK2) is an important target for reversible male contraception. ALK inhibitor 2 (compound 18) contains a methylpiperazine A ring (R1=Me, X=N) and a D ring with R5=methylsulfonamide. ALK inhibitor 2 can undergo metabolic oxidation to form reactive adducts in the presence of glutathione.

target

IC50: 37 nM (TSSK2) and 5 nM (FAK)

ALK inhibitor 2 Preparation Products And Raw materials

Raw materials

Preparation Products

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761438-38-4, ALK inhibitor 2Related Search:

CHLOROMETHYL(DIMETHYL)METHOXYSILANE

ALK inhibitor 2

BenzenesulfonaMide, 2-[[5-chloro-2-[[2-Methoxy-4-(4-Methyl-1-piperazinyl)phenyl]aMino]-4-pyriMidinyl]aMino]-N-Methyl-

2-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methylbenzenesulfonamide

2-[[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]amino]-N-methylbenzenesulfonamide

2-[[5-chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methyl-

2-((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-N-methylbenzenesulfonamide

ALK tyrosine kinase receptor,kinase,Anaplastic lymphoma kinase (ALK),Anaplastic lymphoma kinase,CD246,testis-specific,ALK inhibitor 2,serine/threonine,adhesion,Inhibitor,focal,PTK2 protein tyrosine kinase 2,PTK2,contraception,Cluster of differentiation 246,reversible,ALK inhibitor-2,ALK inhibitor2,inhibit,FAK,Focal adhesion kinase,TSSK2,male

2-[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]-N-methylbenzene-1-sulfonamide

761438-38-4

C23H28ClN7O3S

Inhibitors