ChemicalBook > CAS DataBase List > ALK inhibitor 2
ALK inhibitor 2
- Product Name
- ALK inhibitor 2
- CAS No.
- 761438-38-4
- Chemical Name
- ALK inhibitor 2
- Synonyms
- ALK inhibitor 2;2-[[5-chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methyl-;2-[[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]amino]-N-methylbenzenesulfonamide;2-((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-N-methylbenzenesulfonamide;2-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methylbenzenesulfonamide;BenzenesulfonaMide, 2-[[5-chloro-2-[[2-Methoxy-4-(4-Methyl-1-piperazinyl)phenyl]aMino]-4-pyriMidinyl]aMino]-N-Methyl-;ALK tyrosine kinase receptor,kinase,Anaplastic lymphoma kinase (ALK),Anaplastic lymphoma kinase,CD246,testis-specific,ALK inhibitor 2,serine/threonine,adhesion,Inhibitor,focal,PTK2 protein tyrosine kinase 2,PTK2,contraception,Cluster of differentiation 246,reversible,ALK inhibitor-2,ALK inhibitor2,inhibit,FAK,Focal adhesion kinase,TSSK2,male
- CBNumber
- CB62624075
- Molecular Formula
- C23H28ClN7O3S
- Formula Weight
- 518.03
- MOL File
- 761438-38-4.mol
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ALK inhibitor 2 Property
- Boiling point:
- 712.4±70.0 °C(Predicted)
- Density
- 1.371±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Powder
- pka
- 11.27±0.10(Predicted)
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-0796
- Product name
- ALKinhibitor2
- Purity
- 99.77%
- Packaging
- 5mg
- Price
- $307
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- A3155
- Product name
- ALKinhibitor2
- Packaging
- 5mg
- Price
- $375
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0796
- Product name
- ALKinhibitor2
- Purity
- 99.77%
- Packaging
- 10mg
- Price
- $430
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- A3155
- Product name
- ALKinhibitor2
- Packaging
- 10mg
- Price
- $524
- Updated
- 2021/12/16
Ambeed
- Product number
- A524942
- Product name
- ALKinhibitor2
- Purity
- 98+%
- Packaging
- 250mg
- Price
- $576
- Updated
- 2021/12/16
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ALK inhibitor 2 Chemical Properties,Usage,Production
Biological Activity
ALK inhibitor 2 (compound 18) is a potent, pyrimidine ALK inhibitor. It is a potent testis-specific serine/threonine kinase 2 (TSSK2; IC50=37 nM) and focal adhesion kinase (FAK; IC50=5 nM) inhibitor.
in vitro
Testis-specific serine/threonine kinase 2 (TSSK2) is an important target for reversible male contraception. ALK inhibitor 2 (compound 18) contains a methylpiperazine A ring (R1=Me, X=N) and a D ring with R5=methylsulfonamide. ALK inhibitor 2 can undergo metabolic oxidation to form reactive adducts in the presence of glutathione.
target
IC50: 37 nM (TSSK2) and 5 nM (FAK)
ALK inhibitor 2 Preparation Products And Raw materials
Raw materials
Preparation Products
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