ChemicalBook > CAS DataBase List > E-3810

E-3810

Product Name: E-3810
CAS No.: 1058137-23-7
Chemical Name: E-3810
Synonyms: E-3810;CS-655;AL3810;CO-3810;CS-1836;S 80881;Lucitanib;AL3810 (AL-3810;Lucitanib(E3810);E-3810 USP/EP/BP
CBNumber: CB62624136
Molecular Formula: C26H25N3O4
Formula Weight: 443.49
MOL File: 1058137-23-7.mol

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E-3810 Property

Boiling point:: 696.5±50.0 °C(Predicted)
Density: 1.285±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Powder
pka: 14.65±0.46(Predicted)
color: White to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0782
Product name: Lucitanib
Purity: 99.32%
Packaging: 2mg
Price: $132
Updated: 2021/12/16

ChemScene

Product number: CS-0782
Product name: Lucitanib
Purity: 99.32%
Packaging: 5mg
Price: $228
Updated: 2021/12/16

ChemScene

Product number: CS-0782
Product name: Lucitanib
Purity: 99.32%
Packaging: 10mg
Price: $372
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0017256
Product name: E-3810
Purity: 95.00%
Packaging: 5MG
Price: $427.9
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb180999
Product name: Lucitanib(E3810)
Purity: >98%
Packaging: 100mg
Price: $690.2
Updated: 2021/12/16

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E-3810 Chemical Properties,Usage,Production

Uses

Lucitanib (E-3810) is a novel dual inhibitor of VEGFR and FGFR, potently and selectively inhibits VEGFR1, VEGFR2, VEGFR3, FGFR1 and FGFR2 with IC50s of 7 nM, 25 nM, 10 nM, 17.5 nM, and 82.5 nM, respectively[1][2][3].

Definition

ChEBI: A naphthalenecarboxamide obtained from formal condensation of the carboxy group of aminocyclopropyl)methoxy]-6-methoxyquinolin-4-yl}oxy)-1-naphthoic acid with methylamine.

in vivo

Lucitanib (E-3810), at oral dosing of 20 mg/kg for 7 consecutive days, completely inhibits (P<0.01) the bFGF induced angiogenic response compare with the response in vehicle-treated mice. Lucitanib (E-3810) shows a broad spectrum of activity, being active in all the xenografts tested (HT29 colon carcinoma, A2780 ovarian carcinoma, A498, SN12K1, and RXF393 renal carcinomas) with dose-dependent inhibition of tumor growth. E-3810 significantly delays growth during treatment, but tumors resume their growth when treatment is suspended; in a few cases, tumor regression is observed^[1]. The activity of Lucitanib (E-3810) given at the doses of 15 mg/kg is tested on MDA-MB-231 breast cancer transplanted subcutaneously, at a late stage, when tumor masses reach 350 to 400 mg. This tumor xenograft is very sensitive to Lucitanib (E-3810), with complete tumor stabilization lasting throughout the 30-day treatment. As in other tumor models, tumors re-grow after withdrawal of Lucitanib (E-3810) at a rate similar to control tumors^[3].

target

VEGFR-1

IC 50

VEGFR1: 7 nM (IC₅₀); VEGFR2: 25 nM (IC₅₀); VEGFR3: 10 nM (IC₅₀); FGFR1: 17.5 nM (IC₅₀); FGFR2: 82.5 nM (IC₅₀)

References

[1] Bello E, et al. E-3810 is a potent dual inhibitor of VEGFR and FGFR that exerts antitumor activity in multiple preclinical models. Cancer Res. 2011 Feb 15;71(4):1396-405. DOI:10.1158/0008-5472.CAN-10-2700
[2] Colzani M, et al. Quantitative chemical proteomics identifies novel targets of the anti-cancer multi-kinase inhibitor E-3810. Mol Cell Proteomics. 2014 Jun;13(6):1495-509. DOI:10.1074/mcp.M113.034173
[3] Bello E, et al. The tyrosine kinase inhibitor E-3810 combined with NSC 125973 inhibits the growth of advanced-stage triple-negative breast cancer xenografts. Mol Cancer Ther. 2013 Feb;12(2):131-40 DOI:10.1158/1535-7163.MCT-12-0275-T

E-3810 Preparation Products And Raw materials

Raw materials

Preparation Products

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E-3810 Suppliers

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1058137-23-7, E-3810Related Search:

Iodide oil

Lucitanib(E3810)

CS-655

CS-1836

CO-3810

E 3810; E-3810;CO-3810; S 80881; E-3810

S 80881

E-3810

6-[[7-[(1-Aminocyclopropyl)methoxy]-6-methoxy-4-quinolinyl]oxy]-N-methyl-1-naphthalenecarboxamide

E-3810(Lucitanib)

Lucitanib

6-[[7-[(1-Aminocyclopropyl)methoxy]-6-methoxy-4-quinolinyl]oxy]-N-methyl-1-naphthalenecarboxamide E-3810(Lucitanib)

6-((7-((1-aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yl)oxy)-N-methyl-1-naphthamide

AL3810

6-({7-[(1-Aminocyclopropyl)methoxy]-6-methoxy-4-quinolinyl}oxy)-N-methyl-1-naphthamide

1-Naphthalenecarboxamide, 6-[[7-[(1-aminocyclopropyl)methoxy]-6-methoxy-4-quinolinyl]oxy]-N-methyl-

E-3810 USP/EP/BP

Lucitanib(AL3810）

Fibroblast growth factor receptor,Vascular endothelial growth factor receptor,Inhibitor,FGFR,E3810,inhibit,Lucitanib,E 3810,VEGFR

Lucitanib, 10 mM in DMSO

Lucitanib (E3810) hydrochloride

AL3810 (AL-3810

1058137-23-7