CHF 5074
- Product Name
- CHF 5074
- CAS No.
- 749269-83-8
- Chemical Name
- CHF 5074
- Synonyms
- GHF-5074;CHF 5074;CSP-1103;Itanapraced;Itanapraced (CHF5074);Itanapraced, 10 mM in DMSO;1-(3',4'-Dichloro-2-fluoro-4-biphenylyl)cyclopropanecarboxyl...;1-[4-(3,4-dichlorophenyl)-3-fluorophenyl]cyclopropane-1-carboxylic Acid;1-(3′,4′-Dichloro-2-fluoro[1,1′-biphenyl]-4-yl)-cyclopropanecarboxylic acid;Cyclopropanecarboxylic acid, 1-(3',4'-dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-
- CBNumber
- CB62627687
- Molecular Formula
- C16H11Cl2FO2
- Formula Weight
- 325.16
- MOL File
- 749269-83-8.mol
CHF 5074 Property
- Boiling point:
- 466.4±45.0 °C(Predicted)
- Density
- 1.467±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO:59.0(Max Conc. mg/mL);181.45(Max Conc. mM)
- form
- A solid
- pka
- 2.30±0.20(Predicted)
- color
- White to off-white
- InChI
- InChI=1S/C16H11Cl2FO2/c17-12-4-1-9(7-13(12)18)11-3-2-10(8-14(11)19)16(5-6-16)15(20)21/h1-4,7-8H,5-6H2,(H,20,21)
- InChIKey
- LIYLTQQDABRNRX-UHFFFAOYSA-N
- SMILES
- C1(C2=CC=C(C3=CC=C(Cl)C(Cl)=C3)C(F)=C2)(C(O)=O)CC1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H320Causes eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
N-Bromosuccinimide Price
- Product number
- 27917
- Product name
- CHF5074
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 27917
- Product name
- CHF5074
- Packaging
- 10mg
- Price
- $283
- Updated
- 2024/03/01
- Product number
- 27917
- Product name
- CHF5074
- Packaging
- 5mg
- Price
- $151
- Updated
- 2024/03/01
- Product number
- CS-5022
- Product name
- Itanapraced
- Purity
- >98.0%
- Packaging
- 10mg
- Price
- $160
- Updated
- 2021/12/16
- Product number
- CS-5022
- Product name
- Itanapraced
- Purity
- >98.0%
- Packaging
- 5mg
- Price
- $110
- Updated
- 2021/12/16
CHF 5074 Chemical Properties,Usage,Production
Uses
Itanapraced (CHF5074) is an orally active γ-secretase modulator and a non-steroidal anti-inflammatory derivative. Itanapraced reduces Aβ42 and Aβ40 secretion with IC50 values of 3.6 and 18.4 μM, respectively. Itanapraced inhibits cell apoptosis of hippocampal neurons induced by oxygen and glucose deprivation (OGD). Itanapraced can be used for the research of Alzheimer's disease[1][2].
Biological Activity
Itanapraced (CHF 5074, CSP-1103) is a gamma-secretase modulator that reduces Aβ42 and Aβ40 secretion. It inhibits COX1 and COX2 with IC50 greater than 100 μM.
in vitro
In glioma cells expressing APPswe (H4swe), CHF5074 reduces Aβ42 release with IC50 of 3.6 μM. It had no inhibitory activity against COX-1 and COX-2 at concentrations up to 100 μM and 300 μM.
in vivo
In rats, CHF5074 is well absorbed orally (50%) and is slowly eliminated from plasma (half-life approximately 20 hours). In Tg2576 transgenic mice, chronic treatment of CHF5074 significantly reduced the total amount of Aβ in the brain, and at the histological level, no Notch-mediated toxic effects were found.
target
| Target | Value |
| γ secretase () |