DMAPT

Product Name: DMAPT
CAS No.: 870677-05-7
Chemical Name: DMAPT
Synonyms: DMAPT;DMAPT, 10 mM in DMSO;DMAPT, NF-kappaB inhibitor;Dimethylamino Parthenolide;UJNSFDHVIBGEJZ-KVUCBBCISA-N;NF-κB,Inhibitor,Nuclear factor-κB,inhibit,DMAPT,Nuclear factor-kappaB;(1S,2R,4R,7~{Z},11S,12S)-12-[(dimethylamino)methyl]-4,8-dimethyl-3,14-dioxatricyclo[9.3.0.0^{2,4}]tetradec-7-en-13-one;Oxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one, 8-[(dimethylamino)methyl]-2,3,6,7,7a,8,10a,10b-octahydro-1a,5-dimethyl-, (1aR,4E,7aS,8S,10aS,10bR)-
CBNumber: CB62627768
Molecular Formula: C17H27NO3
Formula Weight: 293.4
MOL File: 870677-05-7.mol

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DMAPT Property

storage temp.: -20°C
solubility: Soluble in DMSO, Ethyl acetate, or Ethanol.
form: solid
color: White
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO, ethanol, or ethyl acetate may be stored at -20° for up to 1 month.
InChIKey: UJNSFDHVIBGEJZ-SQJADDCJSA-N
SMILES: C/C1=C\CC[C@](O2)(C)[C@@]2([H])[C@@H](OC([C@@H]3CN(C)C)=O)[C@@]3([H])CC1

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Safety

WGK Germany: WGK 3
HS Code: 2932209090
Storage Class: 11 - Combustible Solids
Hazard Classifications: Skin Sens. 1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 20436
Product name: Dimethylamino Parthenolide
Purity: ≥99%
Packaging: 10mg
Price: $115
Updated: 2022/04/27

Cayman Chemical

Product number: 20436
Product name: Dimethylamino Parthenolide
Purity: ≥99%
Packaging: 25mg
Price: $242
Updated: 2022/04/27

Biosynth Carbosynth

Product number: BD162719
Product name: Dimethylamino parthenolide
Packaging: 50mg
Price: $250
Updated: 2021/12/16

AK Scientific

Product number: 7347EJ
Product name: Dmapt
Packaging: 25mg
Price: $401
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BD162719
Product name: Dimethylamino parthenolide
Packaging: 25mg
Price: $150
Updated: 2021/12/16

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DMAPT Chemical Properties,Usage,Production

Description

DMAPT (870677-05-7) is a water soluble analog of the natural plant product parthenolide (Cat.# 10-2096) which suppresses in vivo tumor growth of two tobacco-associated neoplasms, lung and bladder cancer. It inhibits NFκB and stimulates the formation of reactive oxygen species which induced the activation of JNK.1 In non-small cell lung cancers DMAPT inhibits NFκB and DNA double-strand break repair.2

Uses

DMAPT is a parthenolide derivative that functions as an antileukemic and cytotoxic agents.

in vivo

Treatment with DMAPT (100 mg/kg, Oral gavage daily for 7 days) increases sensitivity of PC-3 tumor xenografts to X-rays^[2].
DMAPT (100 mg/kg, Oral gavage thrice weekly from 42 to 300 days since birth) treatment slows normal tumor development in TRAMP mice, extending the time-to-palpable prostate tumor by 20%^[3].
DMAPT further reduces the metastatic area below that of the water vehicle treatment group in lung tissues (0.10% ± 0.15 SD, 92% reduction, p = 0.0028) in TRAMP mice^[3].

References

[1] RAJASUBRAMANIAM SHANMUGAM. A water soluble parthenolide analog suppresses in vivo tumor growth of two tobacco-associated cancers, lung and bladder cancer, by targeting NF-κB and generating reactive oxygen species†[J]. International Journal of Cancer, 2010, 128 10: 2481-2494. DOI:10.1002/ijc.25587
[2] NEIL C. ESTABROOK . Inhibition of NF-κB and DNA double-strand break repair by DMAPT sensitizes non-small-cell lung cancers to X-rays[J]. Free Radical Biology and Medicine, 2011, 51 12: Pages 2249-2258. DOI:10.1016/j.freeradbiomed.2011.09.029

DMAPT Preparation Products And Raw materials

Raw materials

Preparation Products

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DMAPT Suppliers

CHINA 24 United Kingdom 1 United States 6 Global 31

BOC Sciences

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TargetMol Chemicals Inc.

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Nantong QuanYi Biotechnology Co., Ltd

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870677-05-7, DMAPTRelated Search:

ZM 447439 Ko 143 LFM-A13 Cantharidin

(1S,2R,4R,7~{Z},11S,12S)-12-[(dimethylamino)methyl]-4,8-dimethyl-3,14-dioxatricyclo[9.3.0.0^{2,4}]tetradec-7-en-13-one

DMAPT

UJNSFDHVIBGEJZ-KVUCBBCISA-N

Dimethylamino Parthenolide

Oxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one, 8-[(dimethylamino)methyl]-2,3,6,7,7a,8,10a,10b-octahydro-1a,5-dimethyl-, (1aR,4E,7aS,8S,10aS,10bR)-

NF-κB,Inhibitor,Nuclear factor-κB,inhibit,DMAPT,Nuclear factor-kappaB

DMAPT, NF-kappaB inhibitor

DMAPT, 10 mM in DMSO

870677-05-7